WormBase Tree Display for Gene: WBGene00006809
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WBGene00006809 | SMap | S_parent | Sequence | C11D2 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | unc | |||||
Reference_allele | WBVar00143348 | |||||
Allele (298) | ||||||
Legacy_information | e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1. | |||||
[C.elegansII] e625 : irregular loopy movement both forward and reverse; active; thin; sometimes protrusive vulva. Slight movement abnormality in e625/+. ES2 ME2 NA1. [Brenner 1974] | ||||||
Strain | WBStrain00035028 | |||||
WBStrain00035029 | ||||||
WBStrain00035482 | ||||||
WBStrain00040855 | ||||||
WBStrain00040862 | ||||||
WBStrain00040863 | ||||||
WBStrain00040864 | ||||||
WBStrain00040865 | ||||||
WBStrain00006352 | ||||||
Component_of_genotype | WBGenotype00000089 | |||||
WBGenotype00000090 | ||||||
WBGenotype00000091 | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (18) | ||||||
Ortholog (51) | ||||||
Paralog | WBGene00003558 | Caenorhabditis elegans | From_analysis | TreeFam | ||
Inparanoid_8 | ||||||
Panther | ||||||
WormBase-Compara | ||||||
WBGene00000367 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00001187 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00006742 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00008911 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
Structured_description | Concise_description | unc-77 encodes, along with nca-2, one of two C. elegans alpha-1-like subunits of a voltage-insensitive cation leak channel related to Drosophila narrow abdomen and the vertebrate Vgcnl1/NALCN proteins; unc-77 functions redundantly with nca-2 to transmit depolarization signals from neuronal cell bodies to axons, thus regulating presynaptic activation; unc-77 and nca-2 are also required for normal locomotion and the response to specific volatile anesthetics; in regulating synaptic activity, unc-77 appears to function in the same pathway as unc-79 and unc-80, which encode novel conserved proteins that reciprocally regulate UNC-77 expression; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-77::gfp reporter fusion is expressed in many sensory and all motoneurons; in the dorsal and ventral nerve cords, UNC-77 localizes to specific axonal regions, but not to synapses. | Paper_evidence | WBPaper00030757 | ||
WBPaper00031000 | ||||||
WBPaper00031592 | ||||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 22 Jun 2010 00:00:00 | |||||
Automated_description | Enables monoatomic cation channel activity. Involved in positive regulation of GABAergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and positive regulation of locomotion. Located in axon. Expressed in cholinergic neurons; nerve ring; pharyngeal neurons; and tail ganglion. Used to study congenital limbs-face contractures-hypotonia-developmental delay syndrome. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Is an ortholog of human NALCN (sodium leak channel, non-selective). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Experimental_model | DOID:0081048 | Homo sapiens | Paper_evidence | WBPaper00046648 | |
Curator_confirmed | WBPerson324 | |||||
Date_last_updated | 09 Feb 2022 00:00:00 | |||||
Potential_model | EFO:MONDO:0014176 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19082) | ||
DOID:0081048 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19082) | |||
Models_disease_asserted | WBDOannot00001101 | |||||
WBDOannot00001105 | ||||||
Molecular_info | Corresponding_CDS (16) | |||||
Corresponding_CDS_history | C11D2.6a:wp239 | |||||
C11D2.6b:wp239 | ||||||
C11D2.6c:wp239 | ||||||
Corresponding_transcript (16) | ||||||
Other_sequence (15) | ||||||
Associated_feature | WBsf651837 | |||||
WBsf996705 | ||||||
WBsf996706 | ||||||
WBsf996707 | ||||||
WBsf996708 | ||||||
WBsf996709 | ||||||
WBsf1017492 | ||||||
WBsf1017493 | ||||||
WBsf230141 | ||||||
WBsf230142 | ||||||
Experimental_info | RNAi_result (15) | |||||
Expr_pattern | Chronogram197 | |||||
Expr4860 | ||||||
Expr5240 | ||||||
Expr8058 | ||||||
Expr8060 | ||||||
Expr8194 | ||||||
Expr8324 | ||||||
Expr1144413 | ||||||
Expr2017906 | ||||||
Expr2036042 | ||||||
Drives_construct (12) | ||||||
Construct_product | WBCnstr00017151 | |||||
WBCnstr00021676 | ||||||
WBCnstr00021677 | ||||||
WBCnstr00021678 | ||||||
WBCnstr00021679 | ||||||
WBCnstr00021680 | ||||||
WBCnstr00021681 | ||||||
WBCnstr00037886 | ||||||
Antibody | WBAntibody00001260 | |||||
WBAntibody00001384 | ||||||
Microarray_results (48) | ||||||
Expression_cluster (190) | ||||||
Interaction (21) | ||||||
Map_info | Map | IV | Position | 3.08555 | ||
Positive | Positive_clone | C11D2 | Inferred_automatically | From sequence, transcript, pseudogene data | ||
Mapping_data | 2_point | 323 | ||||
Multi_point | 1422 | |||||
4509 | ||||||
Reference (42) | ||||||
Method | Gene |