WormBase Tree Display for Gene: WBGene00006810
expand all nodes | collapse all nodes | view schema
| WBGene00006810 | SMap | S_parent | Sequence | C04F6 | |||
|---|---|---|---|---|---|---|---|
| Identity (6) | |||||||
| Gene_info | Biotype | SO:0001217 | |||||
| Gene_class | unc | ||||||
| Reference_allele | WBVar00143840 | ||||||
| Allele (45) | |||||||
| Legacy_information | e1217 : slow abnormal body muscle birefringence abnormal muscle ultrastructure with large aggregates of thin filaments; suppressed to wildtype by sup-13. ES2 ME0. NA > 5 (e1221 st43 etc.). | ||||||
| See also e1217, e1221 | |||||||
| [C.elegansII] e1217 : slow, abnormal body muscle birefringence, abnormal muscle ultrastructure with large aggregates of thin filaments; suppressed to wildtype by sup-13. ES2 ME0. OA>5: e1221, st43 etc. [Waterston et al. 1980] | |||||||
| [S Ono] slow moving, actin filaments become aggregated in body wall muscle. | |||||||
| [Ono S] unc-78 cloned, is C04F6.4 encoding homolog of actin-interacting protein 1, required for organized assembly of muscle actin filaments | |||||||
| Strain | WBStrain00001852 | ||||||
| WBStrain00026896 | |||||||
| WBStrain00033511 | |||||||
| WBStrain00035493 | |||||||
| WBStrain00004274 | |||||||
| WBStrain00006316 | |||||||
| RNASeq_FPKM (74) | |||||||
| GO_annotation (23) | |||||||
| Ortholog (45) | |||||||
| Paralog | WBGene00010685 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||
| Panther | |||||||
| WormBase-Compara | |||||||
| Structured_description | Concise_description | unc-78 encodes a WD40 repeat-containing protein homologous to actin-interacting protein (AIP1) that regulates the ordered assembly of actin and cofilin in myofibrils; homozygous unc-78 mutant animals are viable but exhibit disorganization of actin filaments in the body wall muscle; unc-78 and aipl-1 have redundant and overlapping functions in organized assembly of actin filaments in embryonic muscle and that unc-78 and aipl-1 double mutant is embryonic lethal; both isoforms preferentially cooperate with UNC-60B, a muscle-specific ADF/cofilin for actin filament disassembly in embryonic muscle; UNC-78 is expressed in embryonic pharynx and body wall muscles; in adults it is expressed in spermatheca, the myoepithelial sheath, the uterus, adult vulva; UNC-78 isoform majorly functions in post-embryonic muscle most likely due to its expression in larval and adult muscles and that AIPL-1 can compensate for the function of UNC-78 in the body wall muscle. | Paper_evidence | WBPaper00038403 | |||
| Curator_confirmed | WBPerson12884 | ||||||
| WBPerson567 | |||||||
| Date_last_updated | 12 May 2011 00:00:00 | ||||||
| Automated_description | Enables actin filament binding activity. Involved in several processes, including myofibril assembly; regulation of actin polymerization or depolymerization; and regulation of locomotion. Located in myofibril and sarcoplasm. Expressed in body wall musculature; pharynx; spermatheca; uterus; and vulva. Is an ortholog of human WDR1 (WD repeat domain 1). | Paper_evidence | WBPaper00065943 | ||||
| Curator_confirmed | WBPerson324 | ||||||
| WBPerson37462 | |||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
| Molecular_info | Corresponding_CDS | C04F6.4a | |||||
| Corresponding_CDS_history | C04F6.4b:wp252 | ||||||
| Corresponding_transcript | C04F6.4b | ||||||
| C04F6.4a.1 | |||||||
| Other_sequence (75) | |||||||
| Associated_feature | WBsf653840 | ||||||
| WBsf653841 | |||||||
| WBsf1004608 | |||||||
| WBsf237177 | |||||||
| WBsf237178 | |||||||
| Experimental_info | RNAi_result (20) | ||||||
| Expr_pattern (11) | |||||||
| Drives_construct | WBCnstr00002644 | ||||||
| WBCnstr00011892 | |||||||
| Construct_product | WBCnstr00011504 | ||||||
| WBCnstr00011892 | |||||||
| Antibody | WBAntibody00000674 | ||||||
| Microarray_results (29) | |||||||
| Expression_cluster (136) | |||||||
| Interaction (63) | |||||||
| Map_info | Map | X | Position | -10.3431 | Error | 0.00338 | |
| Well_ordered | |||||||
| Positive | Inside_rearr | yDp13 | |||||
| yDp14 | |||||||
| yDp15 | |||||||
| Positive_clone | C04F6 | Person_evidence | WBPerson463 | ||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 161 | |||||
| Multi_point (15) | |||||||
| Pos_neg_data (18) | |||||||
| Reference (43) | |||||||
| Remark | Data extracted from Ono (2001) | ||||||
| Method | Gene |
