| WBGene00006815 | SMap | S_parent | Sequence | W01A11 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-83 | Person_evidence | WBPerson261 |
| | | Sequence_name | W01A11.3 |
| | | Molecular_name (11) |
| | | Other_name | CeGrip |
| | | | CELE_W01A11.3 | Accession_evidence | NDB | BX284605 |
| | | Public_name | unc-83 |
| | DB_info | Database | WormQTL | gene | WBGene00006815 |
| | | | WormFlux | gene | WBGene00006815 |
| | | | OMIM | disease | 610743 |
| | | | | | 612998 |
| | | | NDB | locus_tag | CELE_W01A11.3 |
| | | | NCBI | gene | 179033 |
| | | | RefSeq | protein | NM_001392533.1 |
| | | | | | NM_001392532.1 |
| | | | | | NM_001083280.3 |
| | | | SwissProt | UniProtAcc | Q23064 |
| | | | TREEFAM | TREEFAM_ID | TF352677 |
| | | | TrEMBL | UniProtAcc | Q0PDL1 |
| | | | | | G8JYF1 |
| | | | UniProt_GCRP | UniProtAcc | Q23064 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143983 |
| | Allele (315) |
| | Legacy_information | e1408ts : reverse kinker as adult variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable some can mate at 25x all can mate at 15x. ES3 ME3 (15x). NA11 (n331amber ts; e1409amber ts (suppressible only for hyp-7 defect)). |
| | | See also e1408, e1409, n159, n1216, n1217, n1218 |
| | | [C.elegansII] e1408ts : reverse kinker as adult, variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect,non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable, some can mate at 25C, all can mate at 15C. ES3 ME3 (15C). NA11: n331amb,ts, e1409amb,ts (suppressible only for hyp-7 defect), n159, n1218 etc. [Sulston and Horvitz 1981; MH; MT] |
| | Strain | WBStrain00026512 |
| | | WBStrain00037609 |
| | | WBStrain00037683 |
| | | WBStrain00004325 |
| | RNASeq_FPKM (74) |
| | GO_annotation (27) |
| | Ortholog (26) |
| | Structured_description | Concise_description | unc-83 encodes a KASH domain-containing transmembrane protein; during development, UNC-83 is required for nuclear migrations in P cells, hyp7 hypodermal precursors, and intestinal cells and thus, for ventral nerve cord development, locomotion, and vulval formation; specifically, UNC-83 functions to recruit kinesin and dynein motor complexes to the nuclear envelope to regulate the directionality and extent of nuclear migrations; UNC-83 localizes to the outer nuclear membrane and its localization is dependent upon the SUN domain of UNC-84, an inner nuclear membrane protein with which it interacts in vitro; UNC-83 and UNC-84 are thus proposed to link the nuclear lamina with the cytoskeleton to properly effect nuclear migrations. | Paper_evidence | WBPaper00000496 |
| | | | | | WBPaper00003628 |
| | | | | | WBPaper00005053 |
| | | | | | WBPaper00005172 |
| | | | | | WBPaper00027107 |
| | | | | | WBPaper00035598 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 23 Apr 2010 00:00:00 |
| | | Automated_description | Enables dynein light chain binding activity. Involved in several processes, including cellular localization; egg-laying behavior; and vulval development. Located in nuclear outer membrane. Expressed in several structures, including P1; P12; P2; P3; and P9. Used to study Emery-Dreifuss muscular dystrophy. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info (2) |
| Models_disease_in_annotation | WBDOannot00000051 |
| Molecular_info | Corresponding_CDS | W01A11.3a |
| | | W01A11.3b |
| | | W01A11.3c |
| | Corresponding_CDS_history | W01A11.3:wp162 |
| | Corresponding_transcript | W01A11.3a.1 |
| | | W01A11.3b.1 |
| | | W01A11.3b.2 |
| | | W01A11.3c.1 |
| | | W01A11.3c.2 |
| | Other_sequence (22) |
| | Associated_feature (57) |
| Experimental_info | RNAi_result | WBRNAi00090325 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00062672 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090007 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00054484 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00065283 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00054483 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089756 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090166 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00062671 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00019442 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Chronogram318 |
| | | Expr1789 |
| | | Expr6810 |
| | | Expr13170 |
| | | Expr1023585 |
| | | Expr1032880 |
| | | Expr1158032 |
| | | Expr2017912 |
| | | Expr2036048 |
| | Drives_construct | WBCnstr00002621 |
| | Antibody | WBAntibody00000447 |
| | | WBAntibody00002169 |
| | Microarray_results (31) |
| | Expression_cluster | WBPaper00029359_1280 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1497 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1604 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045486:starvation_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046741:Garlic-Extract_upregulated_mRNA |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051039:ash-2(RNAi)_regulated_intestine |
| | | WBPaper00051352:Long-Term-Association-Memory_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055969:electromagnetic-field_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057140:pptr-1(tm3103)_upregulated |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058725:sftb-1(cer39)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADF_AWB |
| | | WBPaper00061340:ASG_AWA |
| | | WBPaper00061340:ASI_parent |
| | | WBPaper00061340:ASK_parent |
| | | WBPaper00061340:AUA |
| | | WBPaper00061340:BAG |
| | | WBPaper00061340:CEPsh |
| | | WBPaper00061340:CEPso |
| | | WBPaper00061340:Excretory_gland |
| | | WBPaper00061340:IL1_parent |
| | | WBPaper00061340:Intestinal_and_rectal_muscle |
| | | WBPaper00061340:MC |
| | | WBPaper00061340:Neuroblast_ADE_ADA |
| | | WBPaper00061340:Neuroblast_ASJ_AUA |
| | | WBPaper00061340:Neuroblast_URX_CEPDx |
| | | WBPaper00061340:OLL_parent |
| | | WBPaper00061340:OLQ |
| | | WBPaper00061340:OLQ_grandparent |
| | | WBPaper00061340:OLQ_parent |
| | | WBPaper00061340:URA_parent |
| | | WBPaper00061340:Z1_Z4 |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061527:saeg-1_18803-mpz-2_15880 |
| | | WBPaper00061651:Coelomocyte_enriched |
| | | WBPaper00061651:Distal_tip_cell_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065841:31_0 |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_6_6 |
| | | WBPaper00025032:cluster_16 |
| | | WBPaper00025032:cluster_104 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated |
| | | WBPaper00038060:SUMO-1_downregulated |
| | | WBPaper00038304:octr-1_regulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045960:L1-L4-lethargus_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(143_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction (107) |
| Map_info | Map | V | Position | -0.105154 | Error | 0.00884 |
| | Well_ordered |
| | Positive | Inside_rearr | nDf32 |
| | | | nDf1 |
| | | | nDf18 |
| | | | nDf33 |
| | | Positive_clone | W01A11 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 311 |
| | | Multi_point | 141 |
| | | | 142 |
| | | | 653 |
| | | | 657 |
| | | | 658 |
| | | | 5590 |
| | | Pos_neg_data | 843 |
| | | | 1735 |
| | | | 1748 |
| | | | 6813 |
| | | | 6814 |
| Reference (75) |
| Method | Gene |
