WormBase Tree Display for Gene: WBGene00006816
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| WBGene00006816 | SMap | S_parent | Sequence | F54B11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-84 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F54B11.3 | ||||||||
| Molecular_name | F54B11.3a | ||||||||
| F54B11.3a.1 | |||||||||
| CE28236 | |||||||||
| F54B11.3b | |||||||||
| CE27761 | |||||||||
| F54B11.3b.1 | |||||||||
| Other_name | CELE_F54B11.3 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | unc-84 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143985 | ||||||||
| Allele (156) | |||||||||
| Legacy_information | e1410ts : reverse kinker as adult L1 moves well variable failures in nuclear migrations : same phenotypes as unc-83(e1408). ES3 ME3 (15x). NA16 (e1174 etc. : all alleles ts; complex complementation pattern; null phenotype probably incompletely penetrant). | ||||||||
| See also e1174, e1410, e1411, e1412, e1748, n322, n371, n400, n1219, n1220, n1221, n1325 | |||||||||
| [C.elegansII] e1410ts : reverse kinker as adult, L1 moves well; variable failures in nuclear migrations : same phenotypes as unc-83(e1408). ES3 ME3 (15C). OA>10: e1174, e1748, n296, n1325 etc. (all alleles ts, resemble e1410). Complex complementation pattern; null phenotype probably incompletely penetrant. Cloned: 2.5 kb and 3.5 kb transcripts (different 3' ends), latter encodes predicted 1100 aa protein with TM domain, similarity to fission yeast SPB-associated protein Sad. [Sulston and Horvitz 1981; MH; MT] | |||||||||
| Strain | WBStrain00027087 | ||||||||
| WBStrain00004261 | |||||||||
| WBStrain00004326 | |||||||||
| WBStrain00004389 | |||||||||
| Component_of_genotype | WBGenotype00000137 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (50) | |||||||||
| Paralog | WBGene00006311 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | unc-84 encodes an inner nuclear membrane protein that contains a SUN domain with homology to S. pombe Sad1 and is paralogous to sun-1; SUN proteins include Drosophila Klaroid and CG6589, and mammalian SUN1, SUN2, SUN3 and Spag4; SUN-domain proteins bind lamins and the KASH domain proteins of the outer nuclear membrane; UNC-84 affects nuclear migration and anchoring of various cell types together with UNC-83 and ANC-1, thereby affecting coordinated locomotion, vulval formation, and egg laying; UNC-84 is actively transported from the peripheral endoplasmic reticulum to the nuclear envelope, this process being dependent on two nuclear localization signals, an inner nuclear membrane sorting motif and the SUN-nuclear envelope localization signal; UNC-83 localization at the nuclear envelope requires lamin/lmn-1. | Paper_evidence | WBPaper00000496 | |||||
| WBPaper00000500 | |||||||||
| WBPaper00003628 | |||||||||
| WBPaper00005053 | |||||||||
| WBPaper00005172 | |||||||||
| WBPaper00005468 | |||||||||
| WBPaper00038326 | |||||||||
| WBPaper00040268 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 22 Mar 2012 00:00:00 | ||||||||
| Automated_description | Enables lamin binding activity. Involved in several processes, including egg-laying behavior; nuclear migration along microtubule; and vulval development. Located in nuclear inner membrane. Expressed in several structures, including oocyte. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Is an ortholog of human SUN2 (Sad1 and UNC84 domain containing 2) and SUN3 (Sad1 and UNC84 domain containing 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070184 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16252) | ||||
| Modifies_disease | DOID:070355 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00001300 | ||||||||
| Molecular_info | Corresponding_CDS | F54B11.3a | |||||||
| F54B11.3b | |||||||||
| Corresponding_CDS_history | F54B11.3:wp51 | ||||||||
| F54B11.3a:wp53 | |||||||||
| Corresponding_transcript | F54B11.3a.1 | ||||||||
| F54B11.3b.1 | |||||||||
| Other_sequence (23) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr1153 | ||||||||
| Expr1868 | |||||||||
| Expr1019844 | |||||||||
| Expr1032881 | |||||||||
| Expr1152026 | |||||||||
| Expr2017913 | |||||||||
| Expr2036049 | |||||||||
| Drives_construct (19) | |||||||||
| Construct_product | WBCnstr00008477 | ||||||||
| WBCnstr00008479 | |||||||||
| WBCnstr00008481 | |||||||||
| WBCnstr00008482 | |||||||||
| WBCnstr00008483 | |||||||||
| WBCnstr00008484 | |||||||||
| WBCnstr00034139 | |||||||||
| Antibody | WBAntibody00000468 | ||||||||
| WBAntibody00000475 | |||||||||
| WBAntibody00000476 | |||||||||
| WBAntibody00001058 | |||||||||
| WBAntibody00002545 | |||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (185) | |||||||||
| Interaction (66) | |||||||||
| Map_info | Map | X | Position | 13.7533 | Error | 0.121993 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf34 | |||||||
| Positive_clone | F54B11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| W01D6 | |||||||||
| Mapping_data | 2_point | 173 | |||||||
| 6104 | |||||||||
| 6162 | |||||||||
| Multi_point | 179 | ||||||||
| 180 | |||||||||
| 793 | |||||||||
| 1197 | |||||||||
| 1369 | |||||||||
| 2411 | |||||||||
| 2417 | |||||||||
| 3541 | |||||||||
| 5276 | |||||||||
| Pos_neg_data (26) | |||||||||
| Landmark_gene | |||||||||
| Reference (90) | |||||||||
| Method | Gene |
