unc-103 encodes an ether-a-go-go-related (ERG) K+ channel homolog, orthologous to human KCNH6 (OMIM:608168); UNC-103 regulates muscle activation in motility, egg-laying and male spicule protraction; UNC-103 is expressed highly in many neurons; gain-of-function unc-103 alleles can be uncoordinated, while loss-of-function alleles have a more subtle defect in copulatory spicule protraction.
Predicted to enable inward rectifier potassium channel activity. Involved in mating behavior and regulation of muscle contraction. Predicted to be located in plasma membrane. Predicted to be part of monoatomic ion channel complex. Expressed in body wall musculature; neurons; non-striated muscle; and in male. Used to study long QT syndrome. Human ortholog(s) of this gene implicated in long QT syndrome 2 and short QT syndrome. Is an ortholog of human KCNH2 (potassium voltage-gated channel subfamily H member 2) and KCNH7 (potassium voltage-gated channel subfamily H member 7).