WormBase Tree Display for Gene: WBGene00006831

WBGene00006831 SMap: S_parent: Sequence: C52E12
  Identity: Version: 1
    Name: CGC_name: unc-104 Person_evidence: WBPerson261
      Sequence_name: C52E12.2
      Molecular_name: C52E12.2a
        C52E12.2a.1
        CE48050
        C52E12.2b
        CE47855
        C52E12.2a.2
        C52E12.2b.1
      Other_name: klp-1
        CELE_C52E12.2 Accession_evidence: NDB BX284602
      Public_name: unc-104
    DB_info: Database: AceView gene 2H299
        WormQTL gene WBGene00006831
        WormFlux gene WBGene00006831
        NDB locus_tag CELE_C52E12.2
        Panther gene CAEEL|WormBase=WBGene00006831|UniProtKB=P23678
          family PTHR24115
        NCBI gene 174144
        RefSeq protein NM_001026870.7
            NM_171017.10
        SwissProt UniProtAcc P23678
        UniProt_GCRP UniProtAcc P23678
        OMIM gene 601255
            603060
            605995
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143874
    Allele (221)
    Possibly_affected_by: WBVar02157549
      WBVar02157550
      WBVar02157551
      WBVar02157552
      WBVar02157553
    Legacy_information: L e1265 : severe coiler; e1265/Df probably lethal. ES3 ME0. NA1.
      See also e2184
      [C.elegansII] e1265 : severe coiler; Ric; defects in neuroanatomy; poor response to dauer pheromone;abnormal transport of synaptic vesicles. e1265/Df probably lethal. ES3 ME0. OA>5: rh43(viable, severe), rh142 (sublethal), ut60 (lethal, arrest as coiler), ut104, e2184::Tc1,rh1016, rh1017. Cloned: >30 kb gene, 6 kb transcript, encodes 1584 aa kinesin family protein. [Otsuka et al. 1991; Hall and Hedgecock 1991; Nguyen et al. 1995; DD; NJ]
      [Siddiqui SS]related to kinesin like protein by sequence similarity.
    Strain (19)
    RNASeq_FPKM (74)
    GO_annotation (81)
    Ortholog: WBGene00054230 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00032363 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00137339 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00192754 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00223161 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g7459 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g11865 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP21.g12288 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g4426 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g1282 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g17398 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g11354 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g10022 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g174 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g22283 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g8423 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00458.g11091 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-unc-104 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g12131 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00267.g8321 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_16956 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_16961 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_006395 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02329 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g13441 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g13443 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_20265400 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrII_pilon.g4910 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00207185 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00208428 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00216088 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00246819 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00117727 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00203741 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00276772 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00266694 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00287770 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0267002 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030820-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-070912-480 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-090312-119 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-100913-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:888 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6317 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      HGNC:16636 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      MGI:108391 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:108426 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1098260 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      RGD:70928 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      RGD:621520 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            SonicParanoid
      RGD:1304996 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog (19)
    Structured_description: Concise_description: unc-104 encodes a kinesin-like motor protein homologous to human axonal transporter of synaptic vesicles (ATSV, OMIM: 601255); UNC-104 is required for anterograde axonal transport of synaptic vesicles as well as differentiation of pre- and postsynaptic domains at inhibitory neuromuscular junctions; UNC-104 is expressed solely in neurons; UNC-104 retrograde movement is regulated by PTL-1/Tau, with which it physically interacts in vivo. Paper_evidence: WBPaper00001424
            WBPaper00005798
            WBPaper00038442
          Curator_confirmed: WBPerson1843
          Date_last_updated: 09 Aug 2011 00:00:00
      Automated_description: Enables cytoskeletal protein binding activity; phosphatidylinositol phosphate binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including chemical synaptic transmission; regulation of cellular component organization; and regulation of cellular localization. Located in axon; presynapse; and somatodendritic compartment. Expressed in epithelial cell; muscle cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of the nervous system (multiple); carcinoma (multiple); and neuropathy (multiple). Is an ortholog of human KIF1A (kinesin family member 1A). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (12)
  Molecular_info: Corresponding_CDS: C52E12.2a
      C52E12.2b
    Corresponding_CDS_history: C52E12.2a:wp93
      C52E12.2b:wp93
    Corresponding_transcript: C52E12.2a.1
      C52E12.2a.2
      C52E12.2b.1
    Other_sequence (59)
    Associated_feature (12)
  Experimental_info: RNAi_result (12)
    Expr_pattern (15)
    Drives_construct (41)
    Construct_product (42)
    Antibody: WBAntibody00000733
      WBAntibody00002213
    Microarray_results (29)
    Expression_cluster (225)
    Interaction (134)
    Anatomy_function: WBbtf0455
      WBbtf0456
      WBbtf0457
  Map_info: Map: II Position: 0.210467 Error: 0.00612
    Well_ordered
    Positive: Inside_rearr: mC6
        mDf18
      Positive_clone: C47A5
        C52E12 Inferred_automatically: From sequence, transcript, pseudogene data
        DD#LAJ8
    Negative: Outside_rearr: mcDf1
    Mapping_data: 2_point: 948
        3709
        6169
      Multi_point (16)
      Pos_neg_data: 544
        548
        554
        597
        619
        4514
        4221
        4222
        8958
        10270
  Reference (308)
  Remark: yk16g10.3 removed from sequence list. sdm 11/00
    klp-1 is the same gene as unc-104 and was therefore merged into unc-104
  Method: Gene