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WormBase Tree Display for Gene: WBGene00006853

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Name Class

WBGene00006853SMapS_parentSequenceC47G2
IdentityVersion1
NameCGC_nameunc-130Person_evidenceWBPerson261
Sequence_nameC47G2.2
Molecular_nameC47G2.2
C47G2.2.1
CE02166
Other_nameCELE_C47G2.2Accession_evidenceNDBBX284602
Public_nameunc-130
DB_infoDatabaseAceViewgene2L573
WormQTLgeneWBGene00006853
WormFluxgeneWBGene00006853
NDBlocus_tagCELE_C47G2.2
PanthergeneCAEEL|WormBase=WBGene00006853|UniProtKB=Q18694
familyPTHR11829
NCBIgene174721
RefSeqproteinNM_064010.5
SwissProtUniProtAccQ18694
UniProt_GCRPUniProtAccQ18694
OMIMgene611539
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Allele (36)
StrainWBStrain00031123
WBStrain00040542
WBStrain00029988
RNASeq_FPKM (74)
GO_annotation (27)
Ortholog (60)
ParalogWBGene00001434Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00001438Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00001440Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001441Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00001442Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002601Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003017Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003976Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00004013Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00000912Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionA member of the forkhead domain family of transcription factors that affects the generation of the AWA and ASG chemosensory neurons and is partially required for male tail morphogenesis and embryogenesis; it is expressed in the AWA and ASG precursors; it is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor.Paper_evidenceWBPaper00004379
WBPaper00004380
Curator_confirmedWBPerson324
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and transcription corepressor activity. Involved in several processes, including axon extension involved in axon guidance; negative regulation of transcription by RNA polymerase II; and nematode male tail tip morphogenesis. Located in nucleus. Expressed in several structures, including HO neuron; hypodermis; ray; tail; and ventral body wall muscle. Human ortholog(s) of this gene implicated in glaucoma and vitiligo. Is an ortholog of several human genes including FOXD3 (forkhead box D3); FOXD4 (forkhead box D4); and FOXD4L1 (forkhead box D4 like 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:1686Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3804)
DOID:12306Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3804)
Molecular_infoCorresponding_CDSC47G2.2
Corresponding_transcriptC47G2.2.1
Other_sequenceDviv_isotig17565
CR11553
Dviv_isotig17564
CBC08749_1
CRC07576_1
CR11552
JI182349.1
JI165252.1
Associated_feature (15)
Gene_product_binds (1114)
Transcription_factorWBTranscriptionFactor000007
Experimental_infoRNAi_resultWBRNAi00000983Inferred_automaticallyRNAi_primary
WBRNAi00042701Inferred_automaticallyRNAi_primary
WBRNAi00090262Inferred_automaticallyRNAi_primary
WBRNAi00089792Inferred_automaticallyRNAi_primary
WBRNAi00029926Inferred_automaticallyRNAi_primary
WBRNAi00012086Inferred_automaticallyRNAi_primary
WBRNAi00090104Inferred_automaticallyRNAi_primary
WBRNAi00068017Inferred_automaticallyRNAi_primary
WBRNAi00113567Inferred_automaticallyRNAi_primary
WBRNAi00089944Inferred_automaticallyRNAi_primary
Expr_pattern (16)
Drives_constructWBCnstr00000479
WBCnstr00007747
WBCnstr00014250
WBCnstr00016521
WBCnstr00034122
Construct_productWBCnstr00007747
WBCnstr00014834
WBCnstr00014906
WBCnstr00015401
WBCnstr00034122
AntibodyWBAntibody00000322
Microarray_results (20)
Expression_clusterWBPaper00033065:clk-1(qm30)_upregulated
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00041222:hlh-1(cc561)_downregulated
WBPaper00041222:unc-120(st364)_downregulated
WBPaper00042561:smgl-1(RNAi)_downregulated
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:flat_dev_expression
WBPaper00045316:prg-1_upregulated_L4
WBPaper00045420:fertilization_upregulated_transcript
WBPaper00045521:Spermatogenic
WBPaper00046338:intestine_unique
WBPaper00048923:Aging_regulated
WBPaper00049098:heat-induced_hrde-1(tm1200)
WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
WBPaper00050344:PLM-neuron_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050712:RC301_vs_DA650_4h-PA_upregulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:intestine_expressed
WBPaper00051558:aging_regulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:stavudine_72h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053599:female_vs_male_downregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:eat-2(ad465)_downregulated
WBPaper00055482:Tunicamycin_upregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056167:Cry5B_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056809:smn-1(ok355)_upregulated
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00058711:paraquat_downregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00058969:RIS_depleted
WBPaper00059117:B.subtilis_upregulated
WBPaper00059224:tph-1(mg280)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060014:set-2(zr2012)_downregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:AVL
WBPaper00061340:DB
WBPaper00061340:Excretory_cell_parent
WBPaper00061340:Excretory_duct_and_pore
WBPaper00061340:Neuroblast_ASG_AWA
WBPaper00061340:Neuroblast_AVG_RIR
WBPaper00061340:Parent_of_AMsh_URB
WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3
WBPaper00061340:Parent_of_hyp3_ILsoDx
WBPaper00061340:RIH
WBPaper00061340:RIS
WBPaper00061340:SMB
WBPaper00061341:28C_48h_upregulated
WBPaper00061424:Diet_MYb131_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061527:cfz-2_18944-cfz-2_2268
WBPaper00061530:nhr-49(e2144)_downregulated
WBPaper00062184:PA14_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064769:him-17(me24)_downregulated
WBPaper00064871:hypoxia_downregulated_F2
WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
WBPaper00065749:Heat-Shock_downregulated_N2
WBPaper00065841:142_0
WBPaper00066005:RAGA-1_degradation_somatic_upregulated
cgc4386_cluster_5_1
cgc4489_group_13
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031003:hlh_1_enriched
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00034661:AgNPs_downregulated
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00040985:AIN-2_asynchronous_intestine
WBPaper00040985:AIN-2_asynchronous_muscle
WBPaper00040985:AIN-2_L4_intestine
WBPaper00041174:genotypic
WBPaper00041174:genotypic_prime
WBPaper00042548:miRISC_enriched
WBPaper00045673:colistin_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
[cgc5767]:cluster_5
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(101_min)
[cgc5767]:expression_class_SE
[cgc5767]:expression_class_SE_pi(101_min)
Interaction (185)
Product_binds_matrixWBPmat00005569
Map_info (4)
Reference (49)
MethodGene