WormBase Tree Display for Gene: WBGene00006853

WBGene00006853 SMap: S_parent: Sequence: C47G2
  Identity: Version: 1
    Name: CGC_name: unc-130 Person_evidence: WBPerson261
      Sequence_name: C47G2.2
      Molecular_name: C47G2.2
        C47G2.2.1
        CE02166
      Other_name: CELE_C47G2.2 Accession_evidence: NDB BX284602
      Public_name: unc-130
    DB_info: Database: AceView gene 2L573
        WormQTL gene WBGene00006853
        WormFlux gene WBGene00006853
        NDB locus_tag CELE_C47G2.2
        Panther gene CAEEL|WormBase=WBGene00006853|UniProtKB=Q18694
          family PTHR11829
        NCBI gene 174721
        RefSeq protein NM_064010.5
        SwissProt UniProtAcc Q18694
        UniProt_GCRP UniProtAcc Q18694
        OMIM gene 611539
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele (36)
    Strain: WBStrain00031123
      WBStrain00040542
      WBStrain00029988
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog: WBGene00053536 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00025895 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00162107 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00135423 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00071099 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00068858 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00068853 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00068850 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00066671 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00223083 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g6562 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g9757 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g17801 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g17517 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g22012 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g16642 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g4143 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g9997 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g12307 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g6217 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g17758 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00163.g6013 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-unc-130 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp5_scaffold_00116.g4749 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_23952 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_005379 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10211 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g8241 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_20332900 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrII_pilon.g5909 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00247633 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00247740 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00273977 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00277241 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00266839 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00267178 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00294027 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0004896 Drosophila melanogaster From_analysis: OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-980605-4 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-980605-6 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-980526-143 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-2094 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-070410-88 Danio rerio From_analysis: Hieranoid
            OrthoFinder
            Panther
            PhylomeDB
      HGNC:3802 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            Panther
            SonicParanoid
      HGNC:3805 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:3803 Homo sapiens From_analysis: Hieranoid
            OrthoFinder
            Panther
      HGNC:3804 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:18521 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:18523 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:23762 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:31986 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:18522 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      MGI:1347467 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      MGI:1347473 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1347463 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1347471 Mus musculus From_analysis: Hieranoid
            OrthoFinder
            Panther
      RGD:621715 Rattus norvegicus From_analysis: OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:621712 Rattus norvegicus From_analysis: OrthoFinder
            PhylomeDB
            SonicParanoid
      RGD:621716 Rattus norvegicus From_analysis: OrthoFinder
            PhylomeDB
            SonicParanoid
      RGD:1304642 Rattus norvegicus From_analysis: Hieranoid
            OrthoFinder
            Panther
    Paralog: WBGene00001434 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001438 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001440 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001441 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001442 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002601 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003017 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003976 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00004013 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000912 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: A member of the forkhead domain family of transcription factors that affects the generation of the AWA and ASG chemosensory neurons and is partially required for male tail morphogenesis and embryogenesis; it is expressed in the AWA and ASG precursors; it is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor. Paper_evidence: WBPaper00004379
            WBPaper00004380
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and transcription corepressor activity. Involved in several processes, including axon extension involved in axon guidance; negative regulation of transcription by RNA polymerase II; and nematode male tail tip morphogenesis. Located in nucleus. Expressed in several structures, including HO neuron; hypodermis; ray; tail; and ventral body wall muscle. Human ortholog(s) of this gene implicated in glaucoma and vitiligo. Is an ortholog of several human genes including FOXD3 (forkhead box D3); FOXD4 (forkhead box D4); and FOXD4L1 (forkhead box D4 like 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1686 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3804)
      DOID:12306 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3804)
  Molecular_info: Corresponding_CDS: C47G2.2
    Corresponding_transcript: C47G2.2.1
    Other_sequence: Dviv_isotig17565
      CR11553
      Dviv_isotig17564
      CBC08749_1
      CRC07576_1
      CR11552
      JI182349.1
      JI165252.1
    Associated_feature (15)
    Gene_product_binds (1114)
    Transcription_factor: WBTranscriptionFactor000007
  Experimental_info: RNAi_result: WBRNAi00000983 Inferred_automatically: RNAi_primary
      WBRNAi00042701 Inferred_automatically: RNAi_primary
      WBRNAi00090262 Inferred_automatically: RNAi_primary
      WBRNAi00089792 Inferred_automatically: RNAi_primary
      WBRNAi00029926 Inferred_automatically: RNAi_primary
      WBRNAi00012086 Inferred_automatically: RNAi_primary
      WBRNAi00090104 Inferred_automatically: RNAi_primary
      WBRNAi00068017 Inferred_automatically: RNAi_primary
      WBRNAi00113567 Inferred_automatically: RNAi_primary
      WBRNAi00089944 Inferred_automatically: RNAi_primary
    Expr_pattern (16)
    Drives_construct: WBCnstr00000479
      WBCnstr00007747
      WBCnstr00014250
      WBCnstr00016521
      WBCnstr00034122
    Construct_product: WBCnstr00007747
      WBCnstr00014834
      WBCnstr00014906
      WBCnstr00015401
      WBCnstr00034122
    Antibody: WBAntibody00000322
    Microarray_results (20)
    Expression_cluster (127)
    Interaction (185)
    Product_binds_matrix: WBPmat00005569
  Map_info (4)
  Reference (49)
  Method: Gene