WormBase Tree Display for Gene: WBGene00007197
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| WBGene00007197 | SMap | S_parent | Sequence | B0513 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | prdh-1 | Person_evidence | WBPerson2173 | |||||
| Sequence_name | B0513.5 | ||||||||
| Molecular_name | B0513.5a | ||||||||
| B0513.5a.1 | |||||||||
| CE37309 | |||||||||
| B0513.5b | |||||||||
| CE49937 | |||||||||
| B0513.5b.1 | |||||||||
| Other_name | prodh | Paper_evidence | WBPaper00050536 | ||||||
| CELE_B0513.5 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | prdh-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:47 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 11 Jun 2018 11:44:56 | WBPerson1983 | Name_change | CGC_name | prdh-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | prdh | ||||||||
| Allele (134) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (52) | |||||||||
| Structured_description | Automated_description | Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in mitochondrion. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in hyperprolinemia type 1 and schizophrenia 4. Is an ortholog of human PRODH (proline dehydrogenase 1). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060413 | Homo sapiens | Paper_evidence | WBPaper00047004 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:0070080 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9453) | |||||
| DOID:0080542 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9453) | ||||||
| DOID:9252 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9453) | ||||||
| Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including PRODH (Proline dehydrogenase (oxidase) 1); the C. elegans ortholog prdh-1 knockdown phenotypes include reduced accumulation rate of newly synthesized proteins, extended life span and increased thermo-tolerance. | Homo sapiens | Paper_evidence | WBPaper00047004 | |||||
| Accession_evidence | OMIM | 611867 | |||||||
| 239500 | |||||||||
| 600850 | |||||||||
| 606810 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 15 Sep 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000362 | ||||||||
| Molecular_info | Corresponding_CDS | B0513.5a | |||||||
| B0513.5b | |||||||||
| Corresponding_CDS_history | B0513.5:wp131 | ||||||||
| Corresponding_transcript | B0513.5a.1 | ||||||||
| B0513.5b.1 | |||||||||
| Other_sequence (25) | |||||||||
| Associated_feature | WBsf998468 | ||||||||
| WBsf998469 | |||||||||
| WBsf998470 | |||||||||
| WBsf231172 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00009831 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00000804 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00113437 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039157 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1021073 | ||||||||
| Expr1143312 | |||||||||
| Expr2000233 | |||||||||
| Expr2018453 | |||||||||
| Drives_construct | WBCnstr00033926 | ||||||||
| Construct_product | WBCnstr00033926 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (140) | |||||||||
| Interaction (13) | |||||||||
| Map_info | Map | IV | Position | 10.894 | |||||
| Positive | Positive_clone | B0513 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00049828 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056909 | |||||||||
| WBPaper00061547 | |||||||||
| WBPaper00063976 | |||||||||
| WBPaper00064064 | |||||||||
| WBPaper00065331 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
