WormBase Tree Display for Gene: WBGene00008082
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| WBGene00008082 | SMap | S_parent | Sequence | C44B9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | com-1 | Paper_evidence | WBPaper00031197 | |||||
| Person_evidence | WBPerson1819 | ||||||||
| Sequence_name | C44B9.5 | ||||||||
| Molecular_name | C44B9.5 | ||||||||
| C44B9.5.1 | |||||||||
| CE43543 | |||||||||
| Other_name | CELE_C44B9.5 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | com-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 08 Nov 2004 17:45:49 | WBPerson1983 | Event | Split_into | WBGene00043996 | ||||
| 3 | 19 Nov 2007 17:21:15 | WBPerson2970 | Name_change | CGC_name | com-1 | ||||
| Split_into | WBGene00043996 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | com | ||||||||
| Allele (101) | |||||||||
| Strain | WBStrain00032782 | ||||||||
| WBStrain00007756 | |||||||||
| WBStrain00007765 | |||||||||
| WBStrain00007807 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00061816 | ||||||||
| 00061817 | |||||||||
| 00061818 | |||||||||
| Contained_in_operon | CEOP3883 | ||||||||
| Ortholog (18) | |||||||||
| Paralog | WBGene00009770 | ||||||||
| Structured_description | Concise_description | com-1 encodes an ortholog of budding yeast Sae2p, Arabidopsis AtCOM1, and human RBBP8 (CTIP; OMIM:604124) and C20orf151; like its yeast ortholog, COM-1 is probably required for completing meiotic recombination; meiotic chromosomes in com-1 mutants pair normally, but form irregular chromatin aggregates instead of diakinesis bivalents; while meiotic DNA double-strand breaks (DSBs) are formed, they appear to persist or undergo improper repair, with numerous chromosomal fragments being revealed by REC-8 depletion; conversely, suppression of DSBs by a spo-11 mutation also suppresses the diakinetic com-1 phenotype, and suppression by mre-11 increases com-1 mutant fertility; despite the presence of DSBs, the recombination protein RAD-51, which is known to associate with single-stranded (ss) DNA flanking DSBs, does not localize to meiotic chromosomes in com-1 mutants; exposure of com-1 mutants to gamma-radiation, however, induces RAD-51 foci, which suggests that the failure of RAD-51 to load is specific to meiotic (SPO-11-generated) DSBs; these data suggest that COM-1 helps generate ssDNA tails upon which RAD-51 can bind, after which RAD-51 migrates to homologous DNA tracts and triggers meiotic recombination; com-1 mutants grow and live normally (possibly because of maternally contributed COM-1) but are sterile; the C-terminal-most ~100 residues of COM-1 are strongly conserved, while COM-1's N-terminal ~400 residues have low sequence complexity. | Paper_evidence | WBPaper00031197 | |||||
| WBPaper00031198 | |||||||||
| Person_evidence | WBPerson1819 | ||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 18 Nov 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable damaged DNA binding activity. Predicted to be involved in DNA double-strand break processing involved in repair via single-strand annealing. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Is an ortholog of human RBBP8 (RB binding protein 8, endonuclease). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070013 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9891) | ||||
| Molecular_info | Corresponding_CDS | C44B9.5 | |||||||
| Corresponding_CDS_history | C44B9.5:wp135 | ||||||||
| C44B9.5:wp200 | |||||||||
| Corresponding_transcript | C44B9.5.1 | ||||||||
| Other_sequence | JI482943.1 | ||||||||
| CJC01556_1 | |||||||||
| Associated_feature | WBsf994183 | ||||||||
| WBsf1015872 | |||||||||
| WBsf225773 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00042439 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00006169 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1027979 | ||||||||
| Expr1033510 | |||||||||
| Expr1146428 | |||||||||
| Expr2010448 | |||||||||
| Expr2028688 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (110) | |||||||||
| Interaction (24) | |||||||||
| Map_info | Map | III | Position | 5.56963 | Error | 0.007343 | |||
| Positive | Positive_clone | C44B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
