WormBase Tree Display for Gene: WBGene00009920
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| WBGene00009920 | SMap | S_parent | Sequence | F52B5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | abts-1 | Person_evidence | WBPerson2233 | |||||
| Sequence_name | F52B5.1 | ||||||||
| Molecular_name | F52B5.1a | ||||||||
| F52B5.1a.1 | |||||||||
| CE27167 | |||||||||
| F52B5.1b | |||||||||
| CE42722 | |||||||||
| F52B5.1c | |||||||||
| CE47042 | |||||||||
| F52B5.1b.1 | |||||||||
| F52B5.1c.1 | |||||||||
| Other_name | CELE_F52B5.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | abts-1 | ||||||||
| DB_info | Database | AceView | gene | 1I874 | |||||
| WormQTL | gene | WBGene00009920 | |||||||
| WormFlux | gene | WBGene00009920 | |||||||
| NDB | locus_tag | CELE_F52B5.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00009920|UniProtKB=B3WFV9 | |||||||
| family | PTHR11453 | ||||||||
| NCBI | gene | 172613 | |||||||
| RefSeq | protein | NM_001380825.2 | |||||||
| NM_001380826.1 | |||||||||
| NM_001136304.5 | |||||||||
| TrEMBL | UniProtAcc | G5EDF4 | |||||||
| G5EC65 | |||||||||
| B3WFV9 | |||||||||
| UniProt_GCRP | UniProtAcc | B3WFV9 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:50 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 19 Jan 2005 16:30:54 | WBPerson2970 | Name_change | CGC_name | abts-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | abts | ||||||||
| Allele (112) | |||||||||
| Strain | WBStrain00002307 | ||||||||
| WBStrain00006136 | |||||||||
| WBStrain00032079 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Ortholog (72) | |||||||||
| Paralog | WBGene00019844 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00009929 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00019018 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | abts-1 encodes a sodium-driven chloride-bicarbonate transporter; when expressed in Xenopus oocytes, ABTS-1 exhibits robust chloride transport, as well as chloride/bicarbonate exchange activity; abts-1 responds to arsenite in the environment with an increase in mRNA levels and is required for protection against toxicity of arsenite; abts-1 is involved in cholinergic signaling as abts-1 mutant worms are hypersensitive to the paralytic effects of the cholinesterase inhibitor, aldicarb, and the nicotinic acetylcholine receptor agonist, levamisole, and arsenite enhances both these sensitivities, indicating the neuronal effects of arsenite and abts-1; abts-1 also functions partially redundantly with the potassium chloride co-transporter kcc-2, to mediate inhibitory GABA signaling in the HSNs (hermaphrodite-specific neurons) that control egg-laying, and in body wall muscles that control body length and movement; abts-1 promoter gfp fusions are expressed primarily in neurons and hypodermis, with weak fluorescence also seen in the pharynx and body wall muscle cells. | Paper_evidence | WBPaper00025075 | |||||
| WBPaper00036228 | |||||||||
| WBPaper00038249 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 02 May 2011 00:00:00 | ||||||||
| Automated_description | Enables chloride transmembrane transporter activity and solute:inorganic anion antiporter activity. Involved in several processes, including cholinergic synaptic transmission; regulation of GABAergic synaptic transmission; and response to serotonin. Predicted to be located in plasma membrane. Expressed in HSN; accessory cell; body wall musculature; head; and pharynx. Human ortholog(s) of this gene implicated in cholangiocarcinoma and renal tubular acidosis. Is an ortholog of human SLC4A10 (solute carrier family 4 member 10); SLC4A7 (solute carrier family 4 member 7); and SLC4A8 (solute carrier family 4 member 8). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:4947 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11030) | ||||
| DOID:14219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11030) | ||||||
| Molecular_info | Corresponding_CDS | F52B5.1a | |||||||
| F52B5.1b | |||||||||
| F52B5.1c | |||||||||
| Corresponding_CDS_history | F52B5.1:wp47 | ||||||||
| F52B5.1c:wp229 | |||||||||
| Corresponding_transcript | F52B5.1a.1 | ||||||||
| F52B5.1b.1 | |||||||||
| F52B5.1c.1 | |||||||||
| Other_sequence (57) | |||||||||
| Associated_feature (22) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00003734 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00063711 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082242 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116959 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063709 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082244 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047920 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082243 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00001922 | ||||||||
| WBCnstr00004241 | |||||||||
| WBCnstr00009643 | |||||||||
| WBCnstr00009644 | |||||||||
| WBCnstr00011245 | |||||||||
| WBCnstr00011899 | |||||||||
| WBCnstr00013791 | |||||||||
| WBCnstr00013792 | |||||||||
| WBCnstr00031815 | |||||||||
| Construct_product | WBCnstr00009650 | ||||||||
| WBCnstr00009652 | |||||||||
| WBCnstr00009658 | |||||||||
| WBCnstr00031815 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (152) | |||||||||
| Interaction (25) | |||||||||
| Map_info | Map | I | Position | 2.71185 | Error | 0.006359 | |||
| Positive | Positive_clone | F52B5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5145 | |||||||
| 4212 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
