WormBase Tree Display for Gene: WBGene00010251

WBGene00010251 SMap: S_parent: Sequence: F58E6
  Identity: Version: 3
    Name: CGC_name: sta-2 Person_evidence: WBPerson168
      Sequence_name: F58E6.1
      Molecular_name: F58E6.1
        F58E6.1.1
        CE42515
      Other_name: CELE_F58E6.1 Accession_evidence: NDB BX284605
      Public_name: sta-2
    DB_info: Database: AceView gene 5K227
            5K225
        WormQTL gene WBGene00010251
        WormFlux gene WBGene00010251
        NDB locus_tag CELE_F58E6.1
        Panther gene CAEEL|WormBase=WBGene00010251|UniProtKB=Q20977
          family PTHR11801
        NCBI gene 3565291
        RefSeq protein NM_001129491.3
        SwissProt UniProtAcc Q20977
        UniProt_GCRP UniProtAcc Q20977
        OMIM gene 102582
            600555
            600558
            604260
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 27 Mar 2008 16:32:26 WBPerson4025 Event: Split_into: WBGene00077697
        3 26 Nov 2009 11:16:28 WBPerson9133 Name_change: CGC_name: sta-2
      Split_into: WBGene00077696
        WBGene00077697
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sta
    Allele (32)
    Strain: WBStrain00032243
      WBStrain00021985
      WBStrain00021988
      WBStrain00047518
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (51)
    Paralog: WBGene00013111 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: sta-2 encodes a member of the STAT family of transcription factors; STA-2 functions cell autonomously together with the SNF-12 sodium-dependent neurotransmitter symporter to regulate expression of antimicrobial peptides in the epidermis following fungal infection and physical wounding; STA-2 physically interacts with SNF-12; a sta-2 reporter gene is expressed in the epidermis throughout development and in the seam cells, intestine, phasmid socket cells, excretory duct cell, vulval cells and the dorsal rectal cells; STA-2 localizes to both the nucleus and the cytoplasm; in the epidermal cytoplasm, STA-2 colocalizes with SNF-12 in endocytic-like vesicles near the apical cell surface. Paper_evidence: WBPaper00038424
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 12 May 2014 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to fungus; positive regulation of antifungal peptide production; and response to wounding. Located in several cellular components, including apical part of cell; endocytic vesicle; and hemidesmosome. Part of hemidesmosome associated protein complex. Expressed in hypodermis; interfacial epithelial cell; intestine; and vulva. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of several human genes including STAT1 (signal transducer and activator of transcription 1); STAT3 (signal transducer and activator of transcription 3); and STAT4 (signal transducer and activator of transcription 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (70)
  Molecular_info: Corresponding_CDS: F58E6.1
    Corresponding_CDS_history: F58E6.1:wp20
      F58E6.1a:wp189
      F58E6.1b:wp189
    Corresponding_transcript: F58E6.1.1
    Other_sequence (45)
    Associated_feature: WBsf647106
      WBsf647107
      WBsf661585
      WBsf661586
    Transcription_factor: WBTranscriptionFactor000235
  Experimental_info: RNAi_result: WBRNAi00095190 Inferred_automatically: RNAi_primary
      WBRNAi00095188 Inferred_automatically: RNAi_primary
      WBRNAi00001833 Inferred_automatically: RNAi_primary
      WBRNAi00093457 Inferred_automatically: RNAi_primary
      WBRNAi00110863 Inferred_automatically: RNAi_primary
      WBRNAi00093455 Inferred_automatically: RNAi_primary
      WBRNAi00095189 Inferred_automatically: RNAi_primary
      WBRNAi00015982 Inferred_automatically: RNAi_primary
      WBRNAi00049009 Inferred_automatically: RNAi_primary
      WBRNAi00115101 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9295
      Expr9296
      Expr1023653
      Expr1034471
      Expr1152745
      Expr2016952
      Expr2035100
    Drives_construct: WBCnstr00008724
      WBCnstr00008725
      WBCnstr00008726
    Construct_product: WBCnstr00008727
      WBCnstr00008728
      WBCnstr00008729
      WBCnstr00008730
      WBCnstr00013880
    Antibody: WBAntibody00002618
    Microarray_results (20)
    Expression_cluster (154)
    Interaction (18)
    WBProcess: WBbiopr:00000039
  Map_info: Map: V Position: 2.14428 Error: 0.003978
    Positive: Positive_clone: F58E6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (20)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene