WormBase Tree Display for Gene: WBGene00012936

WBGene00012936 SMap: S_parent: Sequence: Y47D3A
  Identity: Version: 2
    Name: CGC_name: pola-1 Person_evidence: WBPerson30546
      Sequence_name: Y47D3A.29
      Molecular_name: Y47D3A.29
        Y47D3A.29.1
        CE32262
      Other_name: CELE_Y47D3A.29 Accession_evidence: NDB BX284603
      Public_name: pola-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:54 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 05 Apr 2017 11:17:23 WBPerson2970 Name_change: CGC_name: pola-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pola
    Allele (164)
    Strain: WBStrain00051196
    RNASeq_FPKM (74)
    GO_annotation (27)
    Contained_in_operon: CEOP3720
    Ortholog (42)
    Paralog: WBGene00008645 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021344 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: Y47D3A.29 encodes the catalytic subunit of DNA polymerase alpha; large-scale RNAi screens indicate that Y47D3A.29 activity is essential for embryogenesis and required specifically for normal pronuclear migration, as well as normal nuclear position and cell division timing in early blastomeres. Paper_evidence: WBPaper00005654
            WBPaper00006395
            WBPaper00025054
          Curator_confirmed: WBPerson1843
          Date_last_updated: 06 Apr 2007 00:00:00
      Automated_description: Predicted to enable DNA binding activity; DNA-directed DNA polymerase activity; and chromatin binding activity. Predicted to be involved in lagging strand elongation; leading strand elongation; and mitotic DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of alpha DNA polymerase:primase complex. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Is an ortholog of human POLA1 (DNA polymerase alpha 1, catalytic subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111840 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9173)
      DOID:0111834 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9173)
  Molecular_info: Corresponding_CDS: Y47D3A.29
    Corresponding_CDS_history: Y47D3A.29:wp89
      Y47D3A.29b:wp279
    Corresponding_transcript: Y47D3A.29.1
    Other_sequence (28)
    Associated_feature: WBsf645602
      WBsf645603
      WBsf659569
      WBsf659570
      WBsf1015933
      WBsf1015934
      WBsf225798
  Experimental_info: RNAi_result: WBRNAi00075442 Inferred_automatically: RNAi_primary
      WBRNAi00026719 Inferred_automatically: RNAi_primary
      WBRNAi00009341 Inferred_automatically: RNAi_primary
      WBRNAi00056755 Inferred_automatically: RNAi_primary
      WBRNAi00026720 Inferred_automatically: RNAi_primary
      WBRNAi00097143 Inferred_automatically: RNAi_primary
      WBRNAi00114561 Inferred_automatically: RNAi_primary
      WBRNAi00009342 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1012413
      Expr1035733
      Expr1160213
      Expr2014989
      Expr2033224
    Microarray_results (23)
    Expression_cluster (139)
    Interaction: WBInteraction000033353
      WBInteraction000033470
      WBInteraction000033939
      WBInteraction000033940
      WBInteraction000034008
      WBInteraction000034011
      WBInteraction000035679
      WBInteraction000036272
      WBInteraction000036848
      WBInteraction000037749
      WBInteraction000037951
      WBInteraction000037953
      WBInteraction000038806
      WBInteraction000039215
      WBInteraction000042493
      WBInteraction000042979
      WBInteraction000043232
      WBInteraction000044000
      WBInteraction000045836
      WBInteraction000046606
      WBInteraction000047290
      WBInteraction000047494
      WBInteraction000047662
      WBInteraction000103134
      WBInteraction000106493
      WBInteraction000106884
      WBInteraction000107448
      WBInteraction000108773
      WBInteraction000110727
      WBInteraction000113191
      WBInteraction000114677
      WBInteraction000115910
      WBInteraction000120253
      WBInteraction000120521
      WBInteraction000124323
      WBInteraction000124949
      WBInteraction000125383
      WBInteraction000125662
      WBInteraction000127957
      WBInteraction000128837
      WBInteraction000128844
      WBInteraction000128852
      WBInteraction000131198
      WBInteraction000132186
      WBInteraction000132262
      WBInteraction000132527
      WBInteraction000132635
      WBInteraction000132764
      WBInteraction000133008
      WBInteraction000138397
      WBInteraction000146463
      WBInteraction000147692
      WBInteraction000148846
      WBInteraction000149404
      WBInteraction000150314
      WBInteraction000154148
      WBInteraction000154154
      WBInteraction000154159
      WBInteraction000154162
      WBInteraction000154167
      WBInteraction000154271
      WBInteraction000155766
      WBInteraction000155778
      WBInteraction000155779
      WBInteraction000162195
      WBInteraction000162263
      WBInteraction000167778
      WBInteraction000169086
      WBInteraction000169122
      WBInteraction000169459
      WBInteraction000177977
      WBInteraction000185108
      WBInteraction000185808
      WBInteraction000191849
      WBInteraction000201314
      WBInteraction000216729
      WBInteraction000224224
      WBInteraction000250701
      WBInteraction000253673
      WBInteraction000254641
      WBInteraction000269026
      WBInteraction000272928
      WBInteraction000273577
      WBInteraction000278036
      WBInteraction000296639
      WBInteraction000298106
      WBInteraction000302120
      WBInteraction000318586
      WBInteraction000320732
      WBInteraction000327542
      WBInteraction000334750
      WBInteraction000340199
      WBInteraction000343539
      WBInteraction000347705
      WBInteraction000348631
      WBInteraction000349333
      WBInteraction000353616
      WBInteraction000357925
      WBInteraction000362373
      WBInteraction000402276
      WBInteraction000410225
      WBInteraction000413887
      WBInteraction000419916
      WBInteraction000436422
      WBInteraction000450784
      WBInteraction000456701
      WBInteraction000459190
      WBInteraction000464053
      WBInteraction000467831
      WBInteraction000468358
      WBInteraction000468359
      WBInteraction000468802
      WBInteraction000471807
      WBInteraction000473102
      WBInteraction000474085
      WBInteraction000475424
      WBInteraction000523508
      WBInteraction000549146
      WBInteraction000550270
      WBInteraction000559609
      WBInteraction000567883
      WBInteraction000574202
      WBInteraction000575447
  Map_info: Map: III Position: 6.49087
    Positive: Positive_clone: Y47D3A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00031307
    WBPaper00035228
    WBPaper00038491
    WBPaper00054520
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene