Y47D3A.29 encodes the catalytic subunit of DNA polymerase alpha; large-scale RNAi screens indicate that Y47D3A.29 activity is essential for embryogenesis and required specifically for normal pronuclear migration, as well as normal nuclear position and cell division timing in early blastomeres.
Predicted to enable DNA binding activity; DNA-directed DNA polymerase activity; and chromatin binding activity. Predicted to be involved in lagging strand elongation; leading strand elongation; and mitotic DNA replication initiation. Predicted to be located in nucleus. Predicted to be part of alpha DNA polymerase:primase complex. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Is an ortholog of human POLA1 (DNA polymerase alpha 1, catalytic subunit).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.