WormBase Tree Display for Gene: WBGene00018339
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| WBGene00018339 | SMap | S_parent | Sequence | F42A10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | abcf-3 | Paper_evidence | WBPaper00028961 | |||||
| Sequence_name | F42A10.1 | ||||||||
| Molecular_name | F42A10.1 | ||||||||
| F42A10.1.1 | |||||||||
| CE01292 | |||||||||
| F42A10.1.2 | |||||||||
| Other_name | CELE_F42A10.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | abcf-3 | ||||||||
| DB_info | Database | AceView | gene | 3H265 | |||||
| WormQTL | gene | WBGene00018339 | |||||||
| WormFlux | gene | WBGene00018339 | |||||||
| NDB | locus_tag | CELE_F42A10.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00018339|UniProtKB=Q20306 | |||||||
| family | PTHR19211 | ||||||||
| NCBI | gene | 175873 | |||||||
| RefSeq | protein | NM_065938.8 | |||||||
| TREEFAM | TREEFAM_ID | TF105209 | |||||||
| TrEMBL | UniProtAcc | Q20306 | |||||||
| UniProt_GCRP | UniProtAcc | Q20306 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 21 Jun 2007 14:37:04 | WBPerson2970 | Name_change | CGC_name | abcf-3 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | abcf | ||||||||
| Allele (43) | |||||||||
| Strain | WBStrain00036919 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00067765 | ||||||||
| 00067766 | |||||||||
| 00067767 | |||||||||
| 00067768 | |||||||||
| 00067769 | |||||||||
| 00067770 | |||||||||
| 00067771 | |||||||||
| 00067772 | |||||||||
| 00123486 | |||||||||
| 00123487 | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00006512 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00012097 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | abcf-3 encodes a protein with sequence similarity to AAA ATPases that is the C. elegans ortholog of the S. cerevisiae ribosome-association protein Gcn20p; ABCF-3, along with GCN-1, is required for maintaining the steady-state levels of phosphorylated eIF2alpha, and thus for the translational control of a number of mRNAs; ABCF-3 activity is required, in parallel to, or downstream of, the canonical apoptotic pathway, for apoptotic cell death of most somatic cells and germ cells in response to ionizing radiation; in addition, ABCF-3 is required for normal growth rates, and spatial organization of germ cells in the gonad; as in S. cerevisiae, ABCF-3 physically interacts with GCN-1, the C. elegans ortholog of budding yeast Gcn1p, and GCN-1 and ABCF-3 are each required for the other's stability; an abcf-3::gfp promoter fusion is expressed in most cells, including germ cells, throughout development. | Paper_evidence | WBPaper00045601 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 15 Aug 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATP binding activity. Involved in positive regulation of peptidyl-serine phosphorylation; regulation of apoptotic process; and regulation of translation. Predicted to be located in cytosolic ribosome. Expressed in several structures, including body wall musculature; head neurons; hermaphrodite gonad; intestinal cell; and pharyngeal neurons. Is an ortholog of human ABCF3 (ATP binding cassette subfamily F member 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F42A10.1 | |||||||
| Corresponding_transcript | F42A10.1.1 | ||||||||
| F42A10.1.2 | |||||||||
| Other_sequence (124) | |||||||||
| Associated_feature | WBsf645248 | ||||||||
| WBsf645249 | |||||||||
| WBsf658487 | |||||||||
| WBsf225066 | |||||||||
| WBsf225067 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00047060 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00005924 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014789 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032115 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047059 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005121 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047054 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr11921 | ||||||||
| Expr11924 | |||||||||
| Expr1016169 | |||||||||
| Expr1037895 | |||||||||
| Expr1150917 | |||||||||
| Expr2009076 | |||||||||
| Expr2027312 | |||||||||
| Drives_construct | WBCnstr00019542 | ||||||||
| WBCnstr00026600 | |||||||||
| Construct_product | WBCnstr00019543 | ||||||||
| WBCnstr00026600 | |||||||||
| Antibody | WBAntibody00002555 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (110) | |||||||||
| Interaction (118) | |||||||||
| Map_info | Map | III | Position | -1.41034 | Error | 0.000332 | |||
| Positive | Positive_clone | F42A10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00029084 | ||||||||
| WBPaper00033469 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00039498 | |||||||||
| WBPaper00042646 | |||||||||
| WBPaper00045601 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00061765 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
