| WBGene00023497 | SMap | S_parent | Sequence | CHROMOSOME_X |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | lin-15B | Person_evidence | WBPerson261 |
| | | Sequence_name | ZK662.4 |
| | | Molecular_name | ZK662.4 |
| | | | ZK662.4.1 |
| | | | CE15381 |
| | | | ZK662.4.2 |
| | | Other_name | lin-15 | CGC_data_submission |
| | | | CELE_ZK662.4 | Accession_evidence | NDB | BX284606 |
| | | Public_name | lin-15B |
| | DB_info | Database | AceView | gene | XQ349 |
| | | | WormQTL | gene | WBGene00023497 |
| | | | WormFlux | gene | WBGene00023497 |
| | | | NDB | locus_tag | CELE_ZK662.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00023497|UniProtKB=Q27395 |
| | | | | family | PTHR22716 |
| | | | NCBI | gene | 181662 |
| | | | RefSeq | protein | NM_078186.7 |
| | | | SwissProt | UniProtAcc | Q27395 |
| | | | TREEFAM | TREEFAM_ID | TF317492 |
| | | | UniProt_GCRP | UniProtAcc | Q27395 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 24 Aug 2004 15:59:57 | WBPerson1971 | Event | Split_from | WBGene00003004 |
| | | Split_from | WBGene00003004 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lin |
| | Reference_allele | WBVar00089409 |
| | Allele (125) |
| | Legacy_information | n309 : adult hermaphrodite Muv vulva either normal or nonfunctional two to six ventral protrusions. Some animals rupture during L4 molt. Adult males have one to three ventral protrusions rudimentary ectopic hook. ME0. Possibly enhanced phenotype in n309/Df. NA12 (n765ts (wildtype at 15x, Muv at 25x, maternal effect Muv at 20x); n767 (weaker allele wildtype alone Muv in homozygotes with lin-9 lin-35 lin-36 or lin- 37); n744 (weaker allele wildtype alone Muv with lin-8 or lin-38); etc.). |
| | | See also e1763, n309, n374, n377, n743, n744, n765, n1139, n1296, n1331 |
| | | [C.elegansII] n309 : adult hermaphrodite Muv, vulva either normal or nonfunctional, two to six ventral protrusions. Some animals rupture during L4 molt. Adult males have one to three ventral protrusions, rudimentary ectopic hook. ME0. Possibly enhanced phenotype in n309/Df. OA>10: e1763, n765ts (wildtype at 15C, Muv at 25C, maternal effect Muv at 20C); n767 (class A allele, wildtype alone, Muv in homozygotes with lin-9,35,36,37), n744 (class B allele, wildtype alone, Muv with lin-8,38), etc. Cloned: locus encodes two collinear transcripts,B (5') and A (3', SL2 transpliced); encode predicted 1440 aa and 719 aa novel proteins. [Clark et al.1994; Huang et al. 1994; MT; PS] |
| | Strain (191) |
| | RNASeq_FPKM (74) |
| | GO_annotation (14) |
| | Contained_in_operon | CEOPX140 |
| | Ortholog (66) |
| | Paralog | WBGene00002148 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00009728 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00009788 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00012524 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00014040 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00017606 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00017607 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00022067 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | lin-15B encodes a novel protein that contains a THAP domain, a zinc-coordinating, site-specific DNA-binding domain; lin-15B was first identified as a class B synMuv gene that acts redundantly with lin-15A to negatively regulate the outcome of Ras signaling during vulval cell fate specification; subsequently, lin-15B has been shown to also negatively regulate progression through the G1 phase of the cell cycle and RNA-mediated interference (RNAi). | Paper_evidence | WBPaper00001182 |
| | | | | | WBPaper00001949 |
| | | | | | WBPaper00001990 |
| | | | | | WBPaper00005298 |
| | | | | | WBPaper00025108 |
| | | | | | WBPaper00027135 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 03 May 2007 00:00:00 |
| | | Automated_description | Predicted to enable DNA binding activity and metal ion binding activity. Involved in negative regulation of Ras protein signal transduction; negative regulation of vulval development; and regulation of cell fate specification. Expressed in several structures, including anterior gonad arm; oocyte; and somatic cell. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | ZK662.4 |
| | Corresponding_transcript | ZK662.4.1 |
| | | ZK662.4.2 |
| | Other_sequence | CRC03203_1 |
| | | CR11978 |
| | | CRC01656_1 |
| | | CBC11973_1 |
| | | CR03100 |
| | | CRC10613_1 |
| | | CR04582 |
| | Associated_feature | WBsf978574 |
| | | WBsf1008320 |
| | | WBsf1008321 |
| | | WBsf1008322 |
| | | WBsf1008323 |
| | | WBsf1024643 |
| | | WBsf1024644 |
| | | WBsf236808 |
| | Gene_product_binds (4674) |
| | Transcription_factor | WBTranscriptionFactor000008 |
| Experimental_info | RNAi_result (17) |
| | Expr_pattern | Expr11544 |
| | | Expr13120 |
| | | Expr13667 |
| | | Expr1011641 |
| | | Expr1040140 |
| | | Expr1163030 |
| | | Expr1200043 |
| | | Expr2013162 |
| | | Expr2031394 |
| | Drives_construct | WBCnstr00007736 |
| | | WBCnstr00023855 |
| | Construct_product | WBCnstr00007736 |
| | | WBCnstr00016646 |
| | | WBCnstr00019445 |
| | | WBCnstr00019587 |
| | | WBCnstr00019645 |
| | | WBCnstr00020631 |
| | | WBCnstr00021930 |
| | | WBCnstr00023855 |
| | Regulate_expr_cluster | WBPaper00038168:lin-15B(n744)_downregulated |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00062056:lin-15B(n744)_downregulated |
| | | WBPaper00062056:lin-15B(n744)_upregulated |
| | | WBPaper00062056:lin-15B(we23)_downregulated |
| | | WBPaper00062056:lin-15B(we23)_upregulated |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00005432:xbp-1(zc12)_downregulated |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032425:up_in_lin-35 |
| | | WBPaper00032976:non_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY15 |
| | | WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045618:puf-8_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050094:glp-1(gf)_upregulated |
| | | WBPaper00050094:mes-2(bn11)_upregulated |
| | | WBPaper00050094:mes-6(bn66)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F1_hrde-1(tm1200)_upregulated |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051305:vit-2(ac3)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:lin-15B(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056039:hda-6(ok3203)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00056855:his-72(uge40)_upregulated |
| | | WBPaper00057162:meg-3_meg-4_downregulated_sRNA |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059598:HeatShock_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00059754:C.neoformans_H99_upregulated |
| | | WBPaper00060526:plp-1(ok2155)_upregulated |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060951:mrpl-2(osa3)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061274:microgravity_upregulated |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061478:pie-1(ne4433)_upregulated |
| | | WBPaper00061479:hda-1(ne4748)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:R07E4.5-skp-1_1608 |
| | | WBPaper00061651:ADF_enriched |
| | | WBPaper00061651:AIN_enriched |
| | | WBPaper00061651:CAN_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:I1_enriched |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VA_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00064005:starvation_downregulated_N2_protein |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064637:cox-5B(RNAi)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065074:glna(-)_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066085:hda-3(ok1991)_upregulated |
| | | WBPaper00066085:sin-3(syb2172)_upregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_9 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00024671:AFD_vs_AWB_upregulated |
| | | WBPaper00025032:cluster_22 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041370:spg-7(RNAi)_upregulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048567:dnj-14_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:cluster_17 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(122_min) |
| | | [cgc5767]:expression_class_E_pi(41_min) |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | Interaction (314) |
| Map_info | Map | X | Position | 22.9454 | Error | 0.00114 |
| | Well_ordered |
| | Positive | Positive_clone | PS#74B3 |
| | | | ZK662 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 4458 |
| | | | 4457 |
| | | | 6060 |
| | | | 7015 |
| | | | 7082 |
| | | Multi_point | 4524 |
| | | Pos_neg_data | 4461 |
| | | | 491 |
| | | | 518 |
| | | | 519 |
| | | | 536 |
| Reference (328) |
| Remark | To properly reflect that this locus encodes two distinct products, this gene was created from the former lin-15 gene on the advice of the CGC. [krb 040824] |
| Method | Gene |
