WormBase Tree Display for Gene: WBGene00023497

WBGene00023497 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: lin-15B Person_evidence: WBPerson261
      Sequence_name: ZK662.4
      Molecular_name: ZK662.4
        ZK662.4.1
        CE15381
        ZK662.4.2
      Other_name: lin-15 CGC_data_submission
        CELE_ZK662.4 Accession_evidence: NDB BX284606
      Public_name: lin-15B
    DB_info: Database: AceView gene XQ349
        WormQTL gene WBGene00023497
        WormFlux gene WBGene00023497
        NDB locus_tag CELE_ZK662.4
        Panther gene CAEEL|WormBase=WBGene00023497|UniProtKB=Q27395
          family PTHR22716
        NCBI gene 181662
        RefSeq protein NM_078186.7
        SwissProt UniProtAcc Q27395
        TREEFAM TREEFAM_ID TF317492
        UniProt_GCRP UniProtAcc Q27395
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 24 Aug 2004 15:59:57 WBPerson1971 Event: Split_from: WBGene00003004
      Split_from: WBGene00003004
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lin
    Reference_allele: WBVar00089409
    Allele (125)
    Legacy_information: n309 : adult hermaphrodite Muv vulva either normal or nonfunctional two to six ventral protrusions. Some animals rupture during L4 molt. Adult males have one to three ventral protrusions rudimentary ectopic hook. ME0. Possibly enhanced phenotype in n309/Df. NA12 (n765ts (wildtype at 15x, Muv at 25x, maternal effect Muv at 20x); n767 (weaker allele wildtype alone Muv in homozygotes with lin-9 lin-35 lin-36 or lin- 37); n744 (weaker allele wildtype alone Muv with lin-8 or lin-38); etc.).
      See also e1763, n309, n374, n377, n743, n744, n765, n1139, n1296, n1331
      [C.elegansII] n309 : adult hermaphrodite Muv, vulva either normal or nonfunctional, two to six ventral protrusions. Some animals rupture during L4 molt. Adult males have one to three ventral protrusions, rudimentary ectopic hook. ME0. Possibly enhanced phenotype in n309/Df. OA>10: e1763, n765ts (wildtype at 15C, Muv at 25C, maternal effect Muv at 20C); n767 (class A allele, wildtype alone, Muv in homozygotes with lin-9,35,36,37), n744 (class B allele, wildtype alone, Muv with lin-8,38), etc. Cloned: locus encodes two collinear transcripts,B (5') and A (3', SL2 transpliced); encode predicted 1440 aa and 719 aa novel proteins. [Clark et al.1994; Huang et al. 1994; MT; PS]
    Strain: WBStrain00027315
      WBStrain00003908
      WBStrain00022682
      WBStrain00022843
      WBStrain00023457
      WBStrain00023623
      WBStrain00023637
      WBStrain00024134
      WBStrain00024140
      WBStrain00024153
      WBStrain00026380
      WBStrain00026382
      WBStrain00026387
      WBStrain00026388
      WBStrain00026389
      WBStrain00026391
      WBStrain00026392
      WBStrain00026397
      WBStrain00026398
      WBStrain00026720
      WBStrain00026746
      WBStrain00026971
      WBStrain00026972
      WBStrain00027005
      WBStrain00027012
      WBStrain00027064
      WBStrain00027102
      WBStrain00027314
      WBStrain00027328
      WBStrain00027367
      WBStrain00027368
      WBStrain00027440
      WBStrain00027556
      WBStrain00027601
      WBStrain00027617
      WBStrain00028647
      WBStrain00029045
      WBStrain00029065
      WBStrain00029251
      WBStrain00029290
      WBStrain00029467
      WBStrain00030840
      WBStrain00030930
      WBStrain00031121
      WBStrain00034639
      WBStrain00034640
      WBStrain00034655
      WBStrain00035027
      WBStrain00035028
      WBStrain00035029
      WBStrain00035056
      WBStrain00035059
      WBStrain00035060
      WBStrain00035061
      WBStrain00035090
      WBStrain00035099
      WBStrain00040016
      WBStrain00040018
      WBStrain00040158
      WBStrain00040159
      WBStrain00040160
      WBStrain00040161
      WBStrain00040162
      WBStrain00040163
      WBStrain00040164
      WBStrain00040165
      WBStrain00040169
      WBStrain00040633
      WBStrain00040650
      WBStrain00040651
      WBStrain00040653
      WBStrain00040654
      WBStrain00040883
      WBStrain00040884
      WBStrain00040885
      WBStrain00040886
      WBStrain00040887
      WBStrain00040888
      WBStrain00040889
      WBStrain00040890
      WBStrain00040891
      WBStrain00040892
      WBStrain00040893
      WBStrain00040894
      WBStrain00040895
      WBStrain00040896
      WBStrain00040897
      WBStrain00040898
      WBStrain00040899
      WBStrain00040900
      WBStrain00040901
      WBStrain00040902
      WBStrain00040903
      WBStrain00040904
      WBStrain00040905
      WBStrain00040906
      WBStrain00040909
      WBStrain00040910
      WBStrain00040911
      WBStrain00040912
      WBStrain00000020
      WBStrain00000028
      WBStrain00000188
      WBStrain00000313
      WBStrain00000314
      WBStrain00000315
      WBStrain00000316
      WBStrain00000317
      WBStrain00000303
      WBStrain00004017
      WBStrain00004018
      WBStrain00004019
      WBStrain00004849
      WBStrain00005226
      WBStrain00005227
      WBStrain00005248
      WBStrain00005249
      WBStrain00005251
      WBStrain00005252
      WBStrain00005255
      WBStrain00005273
      WBStrain00005284
      WBStrain00005365
      WBStrain00005355
      WBStrain00005550
      WBStrain00005551
      WBStrain00005552
      WBStrain00005553
      WBStrain00005554
      WBStrain00005555
      WBStrain00005556
      WBStrain00005557
      WBStrain00005558
      WBStrain00005559
      WBStrain00005560
      WBStrain00005561
      WBStrain00005562
      WBStrain00005563
      WBStrain00005564
      WBStrain00005565
      WBStrain00005575
      WBStrain00005577
      WBStrain00005578
      WBStrain00005579
      WBStrain00005580
      WBStrain00005581
      WBStrain00005582
      WBStrain00005583
      WBStrain00005600
      WBStrain00005837
      WBStrain00006667
      WBStrain00006671
      WBStrain00006674
      WBStrain00006699
      WBStrain00006700
      WBStrain00007187
      WBStrain00007520
      WBStrain00008269
      WBStrain00008270
      WBStrain00008271
      WBStrain00008279
      WBStrain00008280
      WBStrain00008281
      WBStrain00008282
      WBStrain00008283
      WBStrain00008284
      WBStrain00008285
      WBStrain00008286
      WBStrain00008287
      WBStrain00008288
      WBStrain00008289
      WBStrain00008290
      WBStrain00008291
      WBStrain00008278
      WBStrain00033483
      WBStrain00026416
      WBStrain00026541
      WBStrain00007671
      WBStrain00026540
      WBStrain00005361
      WBStrain00022451
      WBStrain00026420
      WBStrain00026419
      WBStrain00026417
      WBStrain00026418
      WBStrain00027602
      WBStrain00047708
      WBStrain00051805
      WBStrain00051806
      WBStrain00055701
      WBStrain00054860
    RNASeq_FPKM (74)
    GO_annotation (14)
    Contained_in_operon: CEOPX140
    Ortholog (66)
    Paralog: WBGene00002148 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009728 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009788 Caenorhabditis elegans From_analysis: Panther
      WBGene00012524 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00014040 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017606 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017607 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022067 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: lin-15B encodes a novel protein that contains a THAP domain, a zinc-coordinating, site-specific DNA-binding domain; lin-15B was first identified as a class B synMuv gene that acts redundantly with lin-15A to negatively regulate the outcome of Ras signaling during vulval cell fate specification; subsequently, lin-15B has been shown to also negatively regulate progression through the G1 phase of the cell cycle and RNA-mediated interference (RNAi). Paper_evidence: WBPaper00001182
            WBPaper00001949
            WBPaper00001990
            WBPaper00005298
            WBPaper00025108
            WBPaper00027135
          Curator_confirmed: WBPerson1843
          Date_last_updated: 03 May 2007 00:00:00
      Automated_description: Predicted to enable DNA binding activity and metal ion binding activity. Involved in negative regulation of Ras protein signal transduction; negative regulation of vulval development; and regulation of cell fate specification. Expressed in several structures, including anterior gonad arm; oocyte; and somatic cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK662.4
    Corresponding_transcript: ZK662.4.1
      ZK662.4.2
    Other_sequence: CRC03203_1
      CR11978
      CRC01656_1
      CBC11973_1
      CR03100
      CRC10613_1
      CR04582
    Associated_feature: WBsf978574
      WBsf1008320
      WBsf1008321
      WBsf1008322
      WBsf1008323
      WBsf1024643
      WBsf1024644
      WBsf236808
    Gene_product_binds (4674)
    Transcription_factor: WBTranscriptionFactor000008
  Experimental_info: RNAi_result (17)
    Expr_pattern: Expr11544
      Expr13120
      Expr13667
      Expr1011641
      Expr1040140
      Expr1163030
      Expr1200043
      Expr2013162
      Expr2031394
    Drives_construct: WBCnstr00007736
      WBCnstr00023855
    Construct_product: WBCnstr00007736
      WBCnstr00016646
      WBCnstr00019445
      WBCnstr00019587
      WBCnstr00019645
      WBCnstr00020631
      WBCnstr00021930
      WBCnstr00023855
    Regulate_expr_cluster: WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00062056:lin-15B(n744)_downregulated
      WBPaper00062056:lin-15B(n744)_upregulated
      WBPaper00062056:lin-15B(we23)_downregulated
      WBPaper00062056:lin-15B(we23)_upregulated
    Microarray_results (19)
    Expression_cluster (155)
    Interaction (314)
  Map_info: Map: X Position: 22.9454 Error: 0.00114
    Well_ordered
    Positive: Positive_clone: PS#74B3
        ZK662 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 4458
        4457
        6060
        7015
        7082
      Multi_point: 4524
      Pos_neg_data: 4461
        491
        518
        519
        536
  Reference (328)
  Remark: To properly reflect that this locus encodes two distinct products, this gene was created from the former lin-15 gene on the advice of the CGC. [krb 040824]
  Method: Gene