WormBase Tree Display for Interaction: WBInteraction000504526
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| WBInteraction000504526 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00006833 | Interactor_type | Trans_regulator | |
| WBGene00000149 | Interactor_type | Trans_regulated | |||
| Expr_pattern | Expr4548 | ||||
| Interaction_summary | The hypomorphic mutant unc-108(n3263) was crossed to the APL-1::GFP expressing strain. One of the head inter-neurons appeared to have a back-up of protein in the cell body. This aggregation of protein in a distinct compartment was also seen in ventral cord neurons. We then performed colocalization experiments by generating strains expressing APL-1::GFP and mCherry::UNC-108. Similar to the colocalization with RAB-5, APL-1 is found in overlapping puncta with UNC-108 in neurons, demonstrating APL-1 localization to the same compartment. | ||||
| Detection_method | Reporter_gene | [apl-1::gfp], translational fusion | |||
| Regulation_level | Post_transcriptional | ||||
| Regulation_result | Positive_regulate | Anatomy_term | WBbt:0003679 | ||
| Paper | WBPaper00037623 |
