WormBase Tree Display for Interaction: WBInteraction000525317
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| WBInteraction000525317 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00006784 | Interactor_type | Trans_regulated | |
| Transgene | WBTransgene00000786 | ||||
| Construct | WBCnstr00020010 | ||||
| WBGene00006412 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00091560 | Interactor_type | Trans_regulator | ||
| Interaction_summary | A fluorophore-tagged UNC-49B::YFP fusion protein forms clusters that appose the GABAergic presynaptic sites, labeled with SNB-1:: CFP, similar to the antibody-labeled UNC-49 endogenous receptors. Interestingly, in nlg-1(ok259) animals, we observed diffuse YFP fluorescence outlining the muscle cell membranes and failed to detect any obvious UNC-49B::YFP puncta above that diffuse fluorescence component, suggesting that UNC-49B:: YFP properly reaches the plasma membrane but fails to cluster in the absence of NLG-1. | ||||
| Detection_method | Construct | ||||
| Transgene | |||||
| Regulation_result | Positive_regulate | Subcellular_localization | synapse | ||
| Unaffiliated_expr_pattern | Expr5798 | ||||
| Unaffiliated_construct | WBCnstr00000781 | ||||
| Paper | WBPaper00046868 |
