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WormBase Tree Display for Transgene: WBTransgene00000546

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Name Class

WBTransgene00000546Public_namegeIn3
Summary[sir-2.1; rol-6]
ConstructionConstructWBCnstr00000544
Coinjection_otherrol-6
Integration_methodGamma_irradiation
Construction_summarysir-2.1 refers to sequence R11A8.4.
A 2.2 kb genomic fragment of sir-2.1 was injected into N2 along with the rol-6 transformation marker.
Genetic_informationIntegrated
PhenotypeWBPhenotype:0000134Paper_evidenceWBPaper00036476
Curator_confirmedWBPerson712
RemarkOverexpression of SIR-2.1 results in decreased transcription of fat-7 and lbp-6 under both fed and fasted conditions, compared to control animals.Paper_evidenceWBPaper00036476
Curator_confirmedWBPerson712
Caused_by_geneWBGene00004800Paper_evidenceWBPaper00036476
Curator_confirmedWBPerson712
WBPhenotype:0001183Paper_evidenceWBPaper00036476
Curator_confirmedWBPerson712
RemarkIncreased SIR-2.1 activity in nematodes results in lower levels of stored fat, as measured by Sudan Black staining.Paper_evidenceWBPaper00036476
Curator_confirmedWBPerson712
Caused_by_geneWBGene00004800Paper_evidenceWBPaper00036476
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005772PATO:0000460Paper_evidenceWBPaper00036476
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000061Paper_evidenceWBPaper00040229
Curator_confirmedWBPerson712
RemarkStrain (LG100) carrying the integrated transgene array geIn3 [sir-2.1 rol-6(su1006)] (ref. 1) was long-lived; however, outcrossing (x5) of geIn3 to wild type (N2) abrogated the increase in longevity.Paper_evidenceWBPaper00040229
Curator_confirmedWBPerson712
Caused_by_geneWBGene00004800Paper_evidenceWBPaper00040229
Curator_confirmedWBPerson712
Associated_withStrainWBStrain00007690
WBStrain00007691
WBStrain00007692
WBStrain00024177
Reference (25)
SpeciesCaenorhabditis elegans