WormBase Tree Display for Transgene: WBTransgene00001275
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| WBTransgene00001275 | Public_name | nIs51 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | [egl-10(+) + lin-15(+)] | ||||||||
| Construction | Construct | WBCnstr00001266 | |||||||
| Coinjection_other | pEK1[lin-15(+) | ||||||||
| Integration_method | Gamma_irradiation | ||||||||
| Construction_summary | Clone = pMK21. Integrated line overexpressing egl-10 genomic fragment. | ||||||||
| Genetic_information | Integrated | ||||||||
| Map | X | ||||||||
| Phenotype | WBPhenotype:0000016 | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Caused_by_gene | WBGene00001179 | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Affected_by | Molecule | WBMol:00003650 | Paper_evidence | WBPaper00004721 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBMol:00001705 | Paper_evidence | WBPaper00004721 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0007833 | PATO:0001549 | Paper_evidence | WBPaper00004721 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_assay | Treatment | Animals were incubated on agar plates containing 0.1mM Aldicarb, 0.5-1.5 vol% halothane. | Paper_evidence | WBPaper00004721 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000680 | Paper_evidence | WBPaper00004721 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Halothane induced aldicarb resistance is not decreased even at high concentrations of the volatile anesthetic, unlike in WT animals. | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Caused_by_gene | WBGene00001179 | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Affected_by | Molecule | WBMol:00001705 | Paper_evidence | WBPaper00004721 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBMol:00003650 | Paper_evidence | WBPaper00004721 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001618 | Paper_evidence | WBPaper00004721 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Animals exhibit an EC50 of ~1.06 for halothane, whereas N2 has an EC50 of ~0.42 vol%, as determined by a concentration-response curve based on animal dispersal indexes. | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Caused_by_gene | WBGene00001179 | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Variation_effect | Hypermorph_gain_of_function | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Affected_by | Molecule | WBMol:00001705 | Paper_evidence | WBPaper00004721 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001619 | Paper_evidence | WBPaper00004721 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Animals exhibit an EC50 of ~2.25 for isoflurane, whereas N2 has an EC50 of ~0.75 vol% as determined by a concentration-response curve based on animal dispersal indexes. | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Caused_by_gene | WBGene00001179 | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Variation_effect | Hypermorph_gain_of_function | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Affected_by | Molecule | WBMol:00004563 | Paper_evidence | WBPaper00004721 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_not_observed | WBPhenotype:0000641 | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Dispersal index in the absence of anesthetic, ~0.99, is comparable to N2. | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Caused_by_gene | WBGene00001179 | Paper_evidence | WBPaper00004721 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_assay | Treatment | Dispersal assay as reported in Crowder et al.1996; van Swinderen et al. 1997. | Paper_evidence | WBPaper00004721 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| Associated_with | Strain | WBStrain00027315 | |||||||
| Reference (13) | |||||||||
| Species | Caenorhabditis elegans |
