WormBase Tree Display for Variation: WBVar00000076
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WBVar00000076 | Name | Public_name | ad1006 | ||||||
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Sequence_details | SeqStatus | Pending_curation | |||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00005530 | ||||||||
Laboratory | DA | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00001187 | |||||||
Interactor | WBInteraction000519344 | ||||||||
Description | Phenotype | WBPhenotype:0000006 | Paper_evidence | WBPaper00031871 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals retained significantly more eggs in utero than wild-type worms. | Paper_evidence | WBPaper00031871 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Hypomorph_reduction_of_function | Paper_evidence | WBPaper00031871 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00001631 | Paper_evidence | WBPaper00031871 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | DMSO control conditions. | Paper_evidence | WBPaper00031871 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000011 | Paper_evidence | WBPaper00031871 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae. | Paper_evidence | WBPaper00031871 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Hypomorph_reduction_of_function | Paper_evidence | WBPaper00031871 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Animals were treated with various concentrations of nemadipine in DMSO. | Paper_evidence | WBPaper00031871 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000279 | Paper_evidence | WBPaper00031871 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Males could not protrude their spicules. | Paper_evidence | WBPaper00031871 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Hypomorph_reduction_of_function | Paper_evidence | WBPaper00031871 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0005312 | PATO:0000460 | Paper_evidence | WBPaper00031871 | ||||
Curator_confirmed | WBPerson712 | ||||||||
Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00031871 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | DMSO control conditions. | Paper_evidence | WBPaper00031871 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000536 | Paper_evidence | WBPaper00039865 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | When measuring Ca2+ excitability of CEPsh cells in response to high extracellular potassium (HiK+), worms did not have changes to the proportion of non-responders when compared to control cells originating from the background strain. | In cells of egl-19 mutants, the Cat. 2 responses had a reduced preponderance when compared to the background. | Cultured CEPsh glial cells from mutant worms exhibit altered intracellular calcium-based responses to depolarization. | Paper_evidence | WBPaper00039865 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001101 | Paper_evidence | WBPaper00031871 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals retained less eggs after treatment with the dihydropyridine (DHP) analog nemadipine compared to animals treated with DMSO alone; wild-type worms retained more eggs after treatment with the DHP anaolog. | Paper_evidence | WBPaper00031871 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Hypomorph_reduction_of_function | Paper_evidence | WBPaper00031871 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00001631 | Paper_evidence | WBPaper00031871 | |||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | GO_term | GO:0018991 | PATO:0000460 | Paper_evidence | WBPaper00031871 | ||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | 5uM nemadipine in DMSO or DMSO alone | Paper_evidence | WBPaper00031871 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Reference | WBPaper00039865 | ||||||||
WBPaper00031871 | |||||||||
WBPaper00012745 | |||||||||
WBPaper00017464 | |||||||||
WBPaper00023793 | |||||||||
WBPaper00016716 | |||||||||
Method | Allele |