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WormBase Tree Display for Variation: WBVar00000076

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Name Class

WBVar00000076NamePublic_namead1006
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00005530
LaboratoryDA
StatusLive
AffectsGeneWBGene00001187
InteractorWBInteraction000519344
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
RemarkAnimals retained significantly more eggs in utero than wild-type worms.Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001631Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
Phenotype_assayTreatmentDMSO control conditions.Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
WBPhenotype:0000011Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
RemarkAnimals were resistant to population growth retardation induced by nemadipine-A, a dihydropyridine (DHP) analog. In addition, L1 and L2 exhibited variable morphology at concentrations significantly greater than the concentration that induced Vab in wild-type larvae.Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were treated with various concentrations of nemadipine in DMSO.Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
WBPhenotype:0000279Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
RemarkMales could not protrude their spicules.Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005312PATO:0000460Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
Life_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
Phenotype_assayTreatmentDMSO control conditions.Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
WBPhenotype:0000536Paper_evidenceWBPaper00039865
Curator_confirmedWBPerson712
RemarkWhen measuring Ca2+ excitability of CEPsh cells in response to high extracellular potassium (HiK+), worms did not have changes to the proportion of non-responders when compared to control cells originating from the background strain. | In cells of egl-19 mutants, the Cat. 2 responses had a reduced preponderance when compared to the background. | Cultured CEPsh glial cells from mutant worms exhibit altered intracellular calcium-based responses to depolarization.Paper_evidenceWBPaper00039865
Curator_confirmedWBPerson712
WBPhenotype:0001101Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
RemarkAnimals retained less eggs after treatment with the dihydropyridine (DHP) analog nemadipine compared to animals treated with DMSO alone; wild-type worms retained more eggs after treatment with the DHP anaolog.Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001631Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
EQ_annotationsGO_termGO:0018991PATO:0000460Paper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
Phenotype_assayTreatment5uM nemadipine in DMSO or DMSO alonePaper_evidenceWBPaper00031871
Curator_confirmedWBPerson712
ReferenceWBPaper00039865
WBPaper00031871
WBPaper00012745
WBPaper00017464
WBPaper00023793
WBPaper00016716
MethodAllele