Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Variation: WBVar00088240

expand all nodes | collapse all nodes | view schema

Name Class

WBVar00088240EvidencePaper_evidenceWBPaper00003607
NamePublic_namekm2
Other_nameF35C8.8a.1:c.250+1220_251-645del
F35C8.3.2:c.415_861del
CE24941:p.Ala139_Ter287delextTer?
F35C8.3.1:c.415_861del
HGVSgCHROMOSOME_X:g.5369980_5370949del
Sequence_detailsSMapS_parentSequenceF35C8
Flanking_sequencesggaagcggctcttgtggtgtagtcgaatctgctcctgaaagattaactatcgaggtatga
Mapping_targetF35C8
Type_of_mutationDeletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00024034
LaboratoryKU
StatusLive
AffectsGeneWBGene00002177
WBGene00018038
TranscriptF35C8.3.2 (11)
F35C8.8a.1VEP_consequenceintron_variant
VEP_impactMODIFIER
HGVScF35C8.8a.1:c.250+1220_251-645del
Intron_number3/3
F35C8.3.1 (11)
InteractorWBInteraction000001424
WBInteraction000518749
WBInteraction000520420
WBInteraction000520422
WBInteraction000521320
WBInteraction000534884
GeneticsInterpolated_map_positionX-5.40935
Mapping_dataIn_multi_point4449
DescriptionPhenotypeWBPhenotype:0000386Paper_evidenceWBPaper00033433
WBPaper00035318
Curator_confirmedWBPerson2987
RemarkCopper-induced germ cell apoptosis was abolished in jkk-1(km2) mutants (Figure 5A).Paper_evidenceWBPaper00033433
Curator_confirmedWBPerson2987
Cobalt did not induce increased germ cell apoptosis in jkk-1(km2) mutants, as opposed to wild type animals (Table 1)Paper_evidenceWBPaper00035318
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002862Paper_evidenceWBPaper00033433
Curator_confirmedWBPerson2987
WBMol:00003058Paper_evidenceWBPaper00035318
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentWorms were exposed to 10 micromolar of copper for 12 hoursPaper_evidenceWBPaper00033433
Curator_confirmedWBPerson2987
Synchronized young adult hermaphrodites were treated in K-medium with 0.01 millimolar Cobalt chloride for 12 hours, and apoptotic cells were scored after AO staining.Paper_evidenceWBPaper00035318
Curator_confirmedWBPerson2987
WBPhenotype:0000643Paper_evidenceWBPaper00032209
Curator_confirmedWBPerson712
Phenotype_assayTreatmentWell-fed young adults were spotted in the center of normal plates and then killed by chloroform at 4 min after spotting. The percentage of worms located outside of the 2 cm circle was recorded.Paper_evidenceWBPaper00032209
Curator_confirmedWBPerson712
WBPhenotype:0001171Paper_evidenceWBPaper00025132
WBPaper00032241
Curator_confirmedWBPerson712
Remarkmutants show a statistically significant decrease in lifespanPaper_evidenceWBPaper00025132
Curator_confirmedWBPerson712
The jkk-1(km2)-null mutants have a short life span compared with wild type.Paper_evidenceWBPaper00032241
Curator_confirmedWBPerson712
WBPhenotype:0001351Paper_evidenceWBPaper00025132
Curator_confirmedWBPerson712
RemarkPhosphorylated JNK-1 is not detectable.Paper_evidenceWBPaper00025132
Curator_confirmedWBPerson712
WBPhenotype:0001785Paper_evidenceWBPaper00046360
Curator_confirmedWBPerson3142
Phenotype_not_observedWBPhenotype:0000104Paper_evidenceWBPaper00027345
Curator_confirmedWBPerson2987
Remarkjkk-1(km2) mutant males do not exhibit a B cell polarity defectPaper_evidenceWBPaper00027345
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0001715PATO:0000460Paper_evidenceWBPaper00027345
Curator_confirmedWBPerson2987
WBbt:0001750PATO:0000460Paper_evidenceWBPaper00027345
Curator_confirmedWBPerson2987
WBPhenotype:0000142Paper_evidenceWBPaper00031666
Curator_confirmedWBPerson712
RemarkUpregulation of pnlp-29::GFP after infection with D. coniospora was unaltered from that of wild type.Paper_evidenceWBPaper00031666
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were infected with D. coniospora at the L4 stage and maintained on OP50 at 20C.Paper_evidenceWBPaper00031666
Curator_confirmedWBPerson712
GenotypefrIs7Paper_evidenceWBPaper00031666
Curator_confirmedWBPerson712
WBPhenotype:0000315Paper_evidenceWBPaper00004889
Curator_confirmedWBPerson2987
RemarkAbnormalities in touch responses were not detected in jkk-1(km2) mutant animalsPaper_evidenceWBPaper00004889
Curator_confirmedWBPerson2987
WBPhenotype:0000460Paper_evidenceWBPaper00032241
Curator_confirmedWBPerson712
Remarkjkk-1(km2) exhibited normal sensitivity to paraquat.Paper_evidenceWBPaper00032241
Curator_confirmedWBPerson712
WBPhenotype:0000593Paper_evidenceWBPaper00004889
Curator_confirmedWBPerson2987
RemarkFigure 8APaper_evidenceWBPaper00004889
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002862Paper_evidenceWBPaper00004889
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFour worms were allowed to lay eggs in normal NGMSR plates containing the indicated concentrations of heavy metals. After 6 h, worms were removed, and the number of eggs counted. The percentage (+/- standard errors) of worms reaching adulthood 4 days after egg laying is compiled from three experiments.Paper_evidenceWBPaper00004889
Curator_confirmedWBPerson2987
WBPhenotype:0000640Paper_evidenceWBPaper00004889
Curator_confirmedWBPerson2987
WBPhenotype:0001173Paper_evidenceWBPaper00040855
Curator_confirmedWBPerson557
RemarkAdult males show appropriate cell death of the linker cell.Paper_evidenceWBPaper00040855
Curator_confirmedWBPerson557
WBPhenotype:0001655Paper_evidenceWBPaper00004889
Curator_confirmedWBPerson2987
RemarkFigure 8BPaper_evidenceWBPaper00004889
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003022Paper_evidenceWBPaper00004889
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFour worms were allowed to lay eggs in normal NGMSR plates containing the indicated concentrations of heavy metals. After 6 h, worms were removed, and the number of eggs counted. The percentage (+/- standard errors) of worms reaching adulthood 4 days after egg laying is compiled from three experiments.Paper_evidenceWBPaper00004889
Curator_confirmedWBPerson2987
Reference (16)
MethodDeletion_allele