WormBase Tree Display for Variation: WBVar00088424

WBVar00088424 Evidence: Paper_evidence: WBPaper00003665
  Name: Public_name: ky216
    Other_name: F21H11.2a.1:c.3141G>A
      CE38067:p.Trp1047Ter
    HGVSg: CHROMOSOME_III:g.5115245G>A
  Sequence_details: SMap: S_parent: Sequence: F21H11
    Flanking_sequences: gatttcaaaagtttgtatgattttgagatg gaaaacttgactgacattcgtgatagtgtt
    Mapping_target: F21H11
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00024477
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00005244
    Laboratory: CX
    Status: Live
  Affects: Gene: WBGene00004728
    Transcript: F21H11.2a.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: F21H11.2a.1:c.3141G>A
        HGVSp: CE38067:p.Trp1047Ter
        cDNA_position: 3141
        CDS_position: 3141
        Protein_position: 1047
        Exon_number: 13/34
        Codon_change: tgG/tgA
        Amino_acid_change: W/*
  Genetics: Interpolated_map_position: III -2.13286
  Description: Phenotype: WBPhenotype:0001224 Paper_evidence: WBPaper00003665
        Curator_confirmed: WBPerson712
        Remark: posteriorly misdirected axons Paper_evidence: WBPaper00003665
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005394 PATO:0000460 Paper_evidence: WBPaper00003665
                Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00003665
              Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: kyIs4[che-23::GFP] Paper_evidence: WBPaper00003665
              Curator_confirmed: WBPerson712
      WBPhenotype:0002491 Paper_evidence: WBPaper00003665
        Curator_confirmed: WBPerson712
        Remark: Only 26% of mutants showed wild-type ASI amphid neurons outgrowth. Paper_evidence: WBPaper00003665
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: 74% Paper_evidence: WBPaper00003665
              Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005666 PATO:0000460 Paper_evidence: WBPaper00003665
                Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00003665
              Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: kyIs128[str-3::GFP] Paper_evidence: WBPaper00003665
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0001206 Paper_evidence: WBPaper00003665
        Curator_confirmed: WBPerson712
        Remark: Movement is wild-type, scored at 25degC Paper_evidence: WBPaper00003665
            Curator_confirmed: WBPerson712
  Reference: WBPaper00003665
  Method: Substitution_allele