WormBase Tree Display for Variation: WBVar00088500

WBVar00088500 Name: Public_name: lg12501
  Sequence_details: Mapping_target: F52B5
    Type_of_mutation: Deletion
    SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00034662
      WBStrain00034663
      WBStrain00040683
    Laboratory: XY
    Status: Live
  Affects: Gene: WBGene00000467
    Interactor: WBInteraction000504272
      WBInteraction000524863
      WBInteraction000524866
  Description: Phenotype: WBPhenotype:0000044 Paper_evidence: WBPaper00049555
        Curator_confirmed: WBPerson137
      WBPhenotype:0000057 Paper_evidence: WBPaper00049555
        Curator_confirmed: WBPerson137
      WBPhenotype:0000134 Paper_evidence: WBPaper00035965
        Curator_confirmed: WBPerson2021
        Remark: Basal gst-4 expression is significantly reduced in cep-1 mutants compared to their respective wild-type background Paper_evidence: WBPaper00035965
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: gst-4p::gfp Paper_evidence: WBPaper00035965
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000679 Paper_evidence: WBPaper00041842
        Curator_confirmed: WBPerson2987
        Remark: The cep-1(lg12501) mutation results in increased numbers of GFP::LGG-1 foci in embryos, indicative of induced autophagy (Figure 6D) Paper_evidence: WBPaper00041842
            Curator_confirmed: WBPerson2987
      WBPhenotype:0001175 Paper_evidence: WBPaper00048917
          WBPaper00049555
        Curator_confirmed: WBPerson721
          WBPerson137
      WBPhenotype:0001184 Paper_evidence: WBPaper00041842
        Curator_confirmed: WBPerson2987
        Remark: In a frh-1(RNAi) background, the cep-1(lg12501) mutation resulted in increased fat content, compared to controls (Figure S5F; see Corrigendum) Paper_evidence: WBPaper00041842
            Curator_confirmed: WBPerson2987
      WBPhenotype:0002265 Paper_evidence: WBPaper00041842
        Curator_confirmed: WBPerson2987
        Remark: In a frh-1(RNAi) background, the cep-1(lg12501) mutation resulted in increased lysosome-related organelle (LRO) content, compared to controls (Figure S5H; see Corrigendum) Paper_evidence: WBPaper00041842
            Curator_confirmed: WBPerson2987
    Phenotype_not_observed: WBPhenotype:0000966 Paper_evidence: WBPaper00028759
        Curator_confirmed: WBPerson557
        Remark: germline is immortal at 20 and 25 degrees Celsius Paper_evidence: WBPaper00028759
            Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Strains propagated for many generations and checked for sterility Paper_evidence: WBPaper00028759
              Curator_confirmed: WBPerson557
  Reference: WBPaper00041842
    WBPaper00028759
    WBPaper00035965
    WBPaper00048917
    WBPaper00049555
  Remark: lg12501 deletion takes out 1231bp at the C-terminus of CEP-1 Paper_evidence: WBPaper00035965
  Method: Deletion_allele