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WormBase Tree Display for Variation: WBVar00089072

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Name Class

WBVar00089072EvidencePaper_evidenceWBPaper00031061
NamePublic_namemn156
Other_nameCE41239:p.Glu497Gly
F41E6.4a.1:c.1490A>G
F41E6.4b.1:c.782A>G
F41E6.4b.2:c.782A>G
CE41240:p.Glu261Gly
HGVSgCHROMOSOME_V:g.8612640A>G
Sequence_detailsSMapS_parentSequenceF41E6
Flanking_sequencesctgagctttttgggcaactgatcagtgaagaacagatgttattcgtcggcgagatctggc
Mapping_targetF41E6
Type_of_mutationSubstitutionagPaper_evidenceWBPaper00031061
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00034248
LaboratorySP
StatusLive
AffectsGeneWBGene00018285
TranscriptF41E6.4b.2 (12)
F41E6.4b.1 (12)
F41E6.4a.1 (12)
InteractorWBInteraction000519226
GeneticsInterpolated_map_positionV1.48583
Mapping_dataIn_multi_point362
363
366
DescriptionPhenotypeWBPhenotype:0000228Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RemarkNon-Unc revertants of unc-58 were observed on 5/18 plates.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayGenotypeunc-58(e665)Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000275Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RemarkAnimals have extreme sensitivity to UV radiation.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTreatmentUV sensitivities were measured as % survival based on radiation dose. Alkaline bleach isolated eggs ranging in age from 30-180 minutes were aliquoted to plates to give between 25-300 survivors/plate. The plated eggs were irradiated at different doses at a rate of 1Jm 10X-2/sec. Irradiated animals were protected from light. Survival was scored as the % animals reaching adulthood 4-6 days after irradiation relative to un-irradiated controls.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0001175Paper_evidenceWBPaper00048917
Curator_confirmedWBPerson721
RemarkHIM was significant in one experiment but not the otherPaper_evidenceWBPaper00048917
Curator_confirmedWBPerson721
WBPhenotype:0001666Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RemarkAnimals have extreme sensitivity to X-ray radiation.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTreatmentX-ray sensitivities were measured as % survival based on radiation dose. Alkaline bleach isolated eggs ranging in age from 30-180 minutes were aliquoted to plates to give between 25-300 survivors/plate. The plated eggs were irradiated at different doses at a rate of 470 r/min. Survival was scored as the % animals reaching adulthood 4-6 days after irradiation relative to un-irradiated controls.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0001667Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RemarkAnimals are hypersensitive to MMS in a chronic exposure assay where the progeny of L4 larvae exposed to MMS for 24 hours were tested for developmental arrest. Animals are not hypersensitive to MMS exposure in the other chronic sensitivity assay.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were tested in two chronic and 1 acute drug exposure assays: 1. gravid adults were placed on plates containing various concentrations of MMS and allowed to develop; 2. L4 larvae were incubated on plates containing various concentrations of MMS for 24 hours, their progeny were scored for predominant stage of developmental arrest after further incubation; 3. acute exposure was assayed by incubating eggs in 50mM MMS for various times before plating and ounting egg hatch and survival to adulthood.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000050Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000392Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000520Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RemarkAnimals were indistinguishable in appearance from wild type.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000673Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RemarkBrood sizes were similar to that of wild type.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTemperature20CPaper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000742Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTreatmentRecombination frequencies were measured using unlinked intervals, dpy-10 unc-4 or dpy-7 unc-3.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000784Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RemarkMale fertility was 87% that of wild type.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0001175Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0001631Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
RemarkMales produced equal numbers of X-bearing and nullo-X-bearing sperm.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
ReferenceWBPaper00000565
WBPaper00015284
WBPaper00048917
RemarkIn addition to the lesion described the mn156 allele also has D581G and D704G mutationsPaper_evidenceWBPaper00031061
MethodSubstitution_allele