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WormBase Tree Display for Variation: WBVar00089677

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Name Class

WBVar00089677EvidencePaper_evidenceWBPaper00004503
NamePublic_namen691
Other_nameY47H9C.4b.1:c.783del
Y47H9C.4c.1:c.783del
CE30361:p.Asn261LysfsTer35
CE30362:p.Asn261LysfsTer35
CE20264:p.Asn261LysfsTer35
Y47H9C.4a.1:c.783del
HGVSgCHROMOSOME_I:g.11863036del
Sequence_detailsSMapS_parentSequenceY47H9C
Flanking_sequencesccaaaacggagcaacttgcgacaatacaaaggaaaatgtatctgtaaatcaggatatcac
Mapping_targetY47H9C
Type_of_mutationDeletioncPaper_evidenceWBPaper00004503
WBPaper00025002
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00026846
LaboratoryMT
StatusLive
AffectsGeneWBGene00000415
TranscriptY47H9C.4a.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScY47H9C.4a.1:c.783del
HGVSpCE20264:p.Asn261LysfsTer35
cDNA_position789
CDS_position783
Protein_position261
Exon_number6/13
Codon_changeaaC/aa
Amino_acid_changeN/X
Y47H9C.4c.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScY47H9C.4c.1:c.783del
HGVSpCE30362:p.Asn261LysfsTer35
cDNA_position789
CDS_position783
Protein_position261
Exon_number6/12
Codon_changeaaC/aa
Amino_acid_changeN/X
Y47H9C.4b.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScY47H9C.4b.1:c.783del
HGVSpCE30361:p.Asn261LysfsTer35
cDNA_position789
CDS_position783
Protein_position261
Exon_number6/13
Codon_changeaaC/aa
Amino_acid_changeN/X
GeneticsInterpolated_map_positionI12.8819
DescriptionPhenotypeWBPhenotype:0000241Paper_evidenceWBPaper00004503
Curator_confirmedWBPerson712
RemarkCell corpses persisted in the L1 head. No cell corpses were observed in the wild-type L1 head.Paper_evidenceWBPaper00004503
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00004503
Curator_confirmedWBPerson712
WBPhenotype:0000885Paper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
RemarkFailure to engulf cell corpsesPaper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
PenetranceCompletePaper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0003681PATO:0000460Paper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
Life_stageWBls:0000003PATO:0000460Paper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
WBls:0000024PATO:0000460Paper_evidenceWBPaper00001438
Curator_confirmedWBPerson2021
WBPhenotype:0001013Paper_evidenceWBPaper00032003
Curator_confirmedWBPerson712
RemarkAnimals died more quickly than wild-type animals when feeding on live S. enterica, strain 1344.Paper_evidenceWBPaper00032003
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00032003
Curator_confirmedWBPerson712
Phenotype_assayTreatmentA total of 20 ml of culture was plated onto a 3.5 cm plate containing modified NGM (3.5% peptone instead of 2.5%). Synchronized one-day-old adult hermaphroditic nematodes were transferred to lawns of the various bacteria and transferred daily to a fresh lawn until progeny were no longer produced.Paper_evidenceWBPaper00032003
Curator_confirmedWBPerson712
Temperature25Paper_evidenceWBPaper00032003
Curator_confirmedWBPerson712
WBPhenotype:0001171Paper_evidenceWBPaper00032003
Curator_confirmedWBPerson712
RemarkAnimals exhibited a reduced life span when grown on live E. coli, stain OP50, compared with wild-type animals.Paper_evidenceWBPaper00032003
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00032003
Curator_confirmedWBPerson712
Phenotype_assayTemperature25Paper_evidenceWBPaper00032003
Curator_confirmedWBPerson712
ReferenceWBPaper00004503
WBPaper00001438
WBPaper00032003
MethodDeletion_allele