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WormBase Tree Display for Variation: WBVar00089844

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Name Class

WBVar00089844EvidencePaper_evidenceWBPaper00004314
NamePublic_namen942
Other_nameCE28195:p.Trp220Ter
CE28194:p.Trp218Ter
ZK637.7a.1:c.654G>A
ZK637.7b.1:c.660G>A
HGVSgCHROMOSOME_III:g.8903268C>T
Sequence_detailsSMapS_parentSequenceZK637
Flanking_sequencestttgctccgatataagaaagctcgtcaatggtcatgtgcgagttcttctattctgcaatc
Mapping_targetZK637
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00027205
LaboratoryMT
StatusLive
AffectsGeneWBGene00002998
TranscriptZK637.7b.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScZK637.7b.1:c.660G>A
HGVSpCE28195:p.Trp220Ter
cDNA_position666
CDS_position660
Protein_position220
Exon_number5/11
Codon_changetgG/tgA
Amino_acid_changeW/*
ZK637.7a.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScZK637.7a.1:c.654G>A
HGVSpCE28194:p.Trp218Ter
cDNA_position660
CDS_position654
Protein_position218
Exon_number5/11
Codon_changetgG/tgA
Amino_acid_changeW/*
InteractorWBInteraction000502685
WBInteraction000502687
WBInteraction000502690
WBInteraction000518982
GeneticsInterpolated_map_positionIII-0.00581872
Mapping_dataIn_multi_point758
759
DescriptionPhenotypeWBPhenotype:0000154Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
RemarkBrood size is reduced compared to wild-typePaper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
WBPhenotype:0000351Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
Remark71% of fertilized eggs in lin-9(n942) hermaphrodites arrested as embryos and failed to hatchPaper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000003PATO:0000460Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
WBPhenotype:0000399Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
RemarkThe presence of sperm in the body cavity and/or distal gonad demonstrates that the structural integrity of the hermaphrodite gonad is compromisedPaper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
WBPhenotype:0000443Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
RemarkThe copulatory spicules were crumpled and often reduced in sizePaper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005312PATO:0000460Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
Life_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
WBPhenotype:0000668Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
RemarkHermaphrodites had endomitotic oocytes within the proximal oviductPaper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
WBPhenotype:0000688Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkSterile non-Muv alonePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000867Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
Remark71% of fertilized eggs in lin-9(n942) hermaphrodites arrested as embryos and failed to hatchPaper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000003PATO:0000460Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
WBPhenotype:0000977Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
Remarklin-9(n942) hermaphrodite gonads contained four instead of eight sheath cellsPaper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005828PATO:0000460Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
Life_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentGonads were dissected and stained with an anti-CEH-18 antibodyPaper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
WBPhenotype:0001509Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
RemarkThe tails of lin-9(n942) mutant males had fewer than half the normal number of sensory raysPaper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006941PATO:0000460Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
Life_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
WBPhenotype:0001675Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
RemarkIn many lin-9(n942) males, spermatids entered the space between the gonadal basement membrane and the germline epithelium and slipped back distally, away from the seminal vesiclePaper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
Phenotype_not_observedWBPhenotype:0000700Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkNon-Muv alone.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000983Paper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
RemarkSmall brood size does not result from a failure to make functional sperm, because mating wild-type males with lin-9(n942) hermaphrodites did not dramatically increase the brood sizePaper_evidenceWBPaper00004314
Curator_confirmedWBPerson2021
ReferenceWBPaper00014474
WBPaper00004314
MethodSubstitution_allele