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WormBase Tree Display for Variation: WBVar00089967

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Name Class

WBVar00089967EvidencePaper_evidenceWBPaper00002370
NamePublic_namen1125
Other_nameCE45947:p.Glu446Lys
CE46003:p.Glu446Lys
F28C1.2c.1:c.1336G>A
F28C1.2a.1:c.1336G>A
F28C1.2b.1:c.1336G>A
CE24928:p.Glu446Lys
HGVSgCHROMOSOME_V:g.12457142C>T
Sequence_detailsSMapS_parentSequenceF28C1
Flanking_sequencescaaaaattccttgacaaagaatattctggaaaaacttgcggttttggtgggaggtacaaa
Mapping_targetF28C1
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00002370
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryMT
StatusLive
AffectsGeneWBGene00001179
TranscriptF28C1.2c.1 (12)
F28C1.2b.1 (12)
F28C1.2a.1 (12)
GeneticsInterpolated_map_positionV4.2548
Mapping_dataIn_multi_point944
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
RemarkThe penetrance of the egg-laying defect in n1125 heterozygotes is heat-sensitive (especially at 25 C). See Table 7Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
PenetranceCompleteAs shown in Table 5, 11 percent of heterozygotes are Egl. Under homozygous conditions, 100 percent of hermaphrodites are EglPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Semi_dominantPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Phenotype_assayTemperature20Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
WBPhenotype:0001340Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
RemarkSee Table 1Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
PenetranceHighPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Range8181Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Semi_dominantPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Phenotype_assayTreatment0.75 mg/ml imipraminePaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Temperature24Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Phenotype_not_observedWBPhenotype:0001068Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Semi_dominantPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Phenotype_assayTreatment7.5 mg/ml serotoninPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Temperature24Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
ReferenceWBPaper00001133
MethodSubstitution_allele