WormBase Tree Display for Variation: WBVar00089968

WBVar00089968 Evidence: Paper_evidence: WBPaper00004624
  Name: Public_name: n1126
    Other_name: K11G9.4.1:c.599G>T
      CE07377:p.Cys200Phe
    HGVSg: CHROMOSOME_V:g.6680347C>A
  Sequence_details: SMap: S_parent: Sequence: K11G9
    Flanking_sequences: aggacgtgttcaagctggcacaacacaaat tccaagaattgctcacgaggaatacaaatg
    Mapping_target: K11G9
    Type_of_mutation: Substitution: g t Paper_evidence: WBPaper00004624
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: MT
    Status: Live
  Affects: Gene: WBGene00001210
    Transcript: K11G9.4.1 (12)
  Genetics: Interpolated_map_position: V 0.132676
  Description: Phenotype: WBPhenotype:0000006 Paper_evidence: WBPaper00001133
        Curator_confirmed: WBPerson2021
        Penetrance: Complete: Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
          Range: 100 100 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 20 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000154 Paper_evidence: WBPaper00001133
        Curator_confirmed: WBPerson2021
        Remark: Mutants show a 39 percent drop in brood size (compared to wild-type) Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 20 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000181 Paper_evidence: WBPaper00001105
        Curator_confirmed: WBPerson2021
        Remark: HSN axons are posteriorly misdirected and never reach the nerve ring Paper_evidence: WBPaper00001105
            Curator_confirmed: WBPerson2021
        Penetrance: Low: Paper_evidence: WBPaper00001105
              Curator_confirmed: WBPerson2021
          Range: 14 14 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000425 Paper_evidence: WBPaper00001105
        Curator_confirmed: WBPerson2021
        Remark: Serotonin levels are reduced in HSNs (determined immunocytochemically). Paper_evidence: WBPaper00001105
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000470 Paper_evidence: WBPaper00001105
        Curator_confirmed: WBPerson2021
        Remark: HSNs fail to arrive at their final destination (between P5/6 and V4). Paper_evidence: WBPaper00001105
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000038 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000829 Paper_evidence: WBPaper00001133
        Curator_confirmed: WBPerson2021
        Remark: egl-46 mutants produce between 2-5 extra Q daughter cells Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001224 Paper_evidence: WBPaper00001105
        Curator_confirmed: WBPerson2021
        Remark: HSN axons fail to extend ventrally from their cell bodies to the ventral cord and instead extend laterally to reach the nerve ring, their normal destination Paper_evidence: WBPaper00001105
            Curator_confirmed: WBPerson2021
        Penetrance: Low: Paper_evidence: WBPaper00001105
              Curator_confirmed: WBPerson2021
          Range: 3 3 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001105
                Curator_confirmed: WBPerson2021
      WBPhenotype:0001340 Paper_evidence: WBPaper00001133
        Curator_confirmed: WBPerson2021
        Remark: See Table 1 Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
        Penetrance: High: Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
          Range: 94 94 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 0.75 mg/ml imipramine Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
          Temperature: 24 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0001068 Paper_evidence: WBPaper00001133
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001133
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001133
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001133
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 7.5 mg/ml serotonin Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
          Temperature: 24 Paper_evidence: WBPaper00001133
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00001105
    WBPaper00001133
  Method: Substitution_allele