Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Variation: WBVar00090957

expand all nodes | collapse all nodes | view schema

Name Class

WBVar00090957NamePublic_namene19
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryWM
StatusLive
AffectsGeneWBGene00003396
InteractorWBInteraction000000920
WBInteraction000500033
WBInteraction000500034
WBInteraction000521873
WBInteraction000521875
WBInteraction000521876
WBInteraction000524346
WBInteraction000538510
DescriptionPhenotypeWBPhenotype:0000414Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
Remark13 out of 22 E blastomeres isolated by laser ablation from mom-4(ne19) mutant embryos failed to produce endoderm and instead produced mesodermal tissues similar to those produced by its (E's) anterior sister MS (data not shown).Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
PenetranceIncomplete59% penetrancePaper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004804PATO:0000460Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
Life_stageWBls:0000003PATO:0000460Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
WBPhenotype:0000472Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
RemarkThe mom-4(ne19) mutation results in 43% of embryos lacking endoderm (Table 1).Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
PenetranceIncomplete43% penetrantPaper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
EQ_annotationsLife_stageWBls:0000003PATO:0000460Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
WBPhenotype:0001495Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
RemarkIn lineaged mom-4(ne19) mutant embryos the E lineage exhibited accelerated division timing that was correlated with the corresponding cell transformation phenotype (data not shown).Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005208PATO:0000460Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
Life_stageWBls:0000003PATO:0000460Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
WBPhenotype:0001637Paper_evidenceWBPaper00005375
Curator_confirmedWBPerson2987
Remark46% of mom-4(ne19) embryos lacked an intestine (Table 1)Paper_evidenceWBPaper00005375
Curator_confirmedWBPerson2987
PenetranceIncomplete46Paper_evidenceWBPaper00005375
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005772PATO:0000460Paper_evidenceWBPaper00005375
Curator_confirmedWBPerson2987
WBPhenotype:0002216Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
RemarkIn wild-type embryos, the anterior EMS daughter cell (MS) nucleus shows higher levels of POP-1 immunostaining than the posterior sister (E). mom-4(ne19) embryos show equal staining in the nuclei of both anterior and posterior sisters (Figure 1).Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006876PATO:0000460Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
WBbt:0004804PATO:0000460Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
WBbt:0004458PATO:0000460Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
Life_stageWBls:0000003PATO:0000460Paper_evidenceWBPaper00003656
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0001133Paper_evidenceWBPaper00005375
Curator_confirmedWBPerson2987
Remarkmom-4(ne19) animals exhibited no embryos with aberrant L-R division of EMS (Table 1)Paper_evidenceWBPaper00005375
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006876PATO:0000460Paper_evidenceWBPaper00005375
Curator_confirmedWBPerson2987
ReferenceWBPaper00005375
WBPaper00003656
MethodAllele