WormBase Tree Display for Variation: WBVar00090999

WBVar00090999 Evidence: Paper_evidence: WBPaper00026736
  Name: Public_name: ne1991
    Other_name (12)
    HGVSg: CHROMOSOME_III:g.13720204T>C
  Sequence_details: SMap: S_parent: Sequence: W06F12
    Flanking_sequences: gtaagcgagtgtttcgagaaatcaaaatgc cagctcattccgacatgacaacgttctctc
    Mapping_target: W06F12
    Type_of_mutation: Substitution: t c Paper_evidence: WBPaper00026736
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00040429
    Laboratory: WM
    Status: Live
  Affects: Gene: WBGene00003048
    Transcript: W06F12.1a.1 (12)
      W06F12.1c.1 (12)
      W06F12.1b.1 (12)
      W06F12.1e.1 (12)
      W06F12.1d.2 (12)
      W06F12.1d.1 (12)
      W06F12.1d.3 (12)
    Interactor: WBInteraction000502189
      WBInteraction000519778
      WBInteraction000542275
      WBInteraction000542276
  Genetics: Interpolated_map_position: III 21.3994
  Description: Phenotype: WBPhenotype:0000050 Paper_evidence: WBPaper00026736
        Curator_confirmed: WBPerson2021
        Remark: Mutants have defects in P2/EMS signaling Paper_evidence: WBPaper00026736
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00026736
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00026736
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 25C Paper_evidence: WBPaper00026736
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000436 Paper_evidence: WBPaper00026736
        Curator_confirmed: WBPerson2021
        Remark: WRM-1 levels were absent in the E nucleus. In lit-1 mutants, the GFP signal was strongly excluded from the nucleus in all cells in the early embryo. This nuclear exclusion was not dependent on IMB-4 Paper_evidence: WBPaper00026736
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0001975 PATO:0000460 Paper_evidence: WBPaper00026736
                Curator_confirmed: WBPerson2021
            WBbt:0001001 PATO:0000460 Paper_evidence: WBPaper00026736
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000071 PATO:0000460 Paper_evidence: WBPaper00026736
                Curator_confirmed: WBPerson2021
            WBls:0000007 PATO:0000460 Paper_evidence: WBPaper00026736
                Curator_confirmed: WBPerson2021
            WBls:0000008 PATO:0000460 Paper_evidence: WBPaper00026736
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25C Paper_evidence: WBPaper00026736
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: lit-1 mutants carrying the WRM-1::GFP transgene were examined. Nuclear retention was assayed by subjecting the animals to imb-4 RNAi Paper_evidence: WBPaper00026736
              Curator_confirmed: WBPerson2021
          Temperature: 25C Paper_evidence: WBPaper00026736
              Curator_confirmed: WBPerson2021
          Genotype: neIs2 [WRM-1::GFP] Paper_evidence: WBPaper00026736
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001236 Paper_evidence: WBPaper00045459
        Curator_confirmed: WBPerson15416
        Remark: Figure 5, POPTOP reporter expression increased in L4 hermaphrodite somatic gonad Paper_evidence: WBPaper00045459
            Curator_confirmed: WBPerson15416
  Reference: WBPaper00026736
    WBPaper00045459
  Method: Substitution_allele