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WormBase Tree Display for Variation: WBVar00092501

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Name Class

WBVar00092501EvidencePerson_evidenceWBPerson14863
NamePublic_nameok1255
Other_nameCE46969:p.Ile71LysfsTer27
Y47D3A.16.1:c.212_1016del
HGVSgCHROMOSOME_III:g.11246933_11248745del
Sequence_detailsSMapS_parentSequenceY47D3A
Flanking_sequencestggaatcgattcaactgtgtgccagtgcaaaagtcatgcgtttttcaagactacggactg
Mapping_targetY47D3A
Type_of_mutationDeletion
PCR_productOK1255_external
OK1255_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00031907
WBStrain00057383
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00012929
TranscriptY47D3A.16.1 (11)
InteractorWBInteraction000008531
WBInteraction000008533
WBInteraction000008534
WBInteraction000500251
WBInteraction000520358
WBInteraction000521005
WBInteraction000573292
GeneticsInterpolated_map_positionIII8.08606
Mapping_dataIn_multi_point5138
DescriptionPhenotypeWBPhenotype:0000061Paper_evidenceWBPaper00029007
WBPaper00036348
WBPaper00039835
Curator_confirmedWBPerson557
WBPerson2021
Remarkrsks-1 mutation produced a moderate increase in lifespan compared to wild-typePaper_evidenceWBPaper00036348
Curator_confirmedWBPerson2021
WBPhenotype:0000121Paper_evidenceWBPaper00029007
Curator_confirmedWBPerson557
RemarkReduced rate of protein translation.Paper_evidenceWBPaper00029007
Curator_confirmedWBPerson557
WBPhenotype:0000473Paper_evidenceWBPaper00036348
Curator_confirmedWBPerson2021
RemarkQualitatively, these animals appeared uncoordinated as they aged both when examined on plates or in liquid.Paper_evidenceWBPaper00036348
Curator_confirmedWBPerson2021
WBPhenotype:0000674Paper_evidenceWBPaper00029007
Curator_confirmedWBPerson557
RemarkRate of development decreased.Paper_evidenceWBPaper00029007
Curator_confirmedWBPerson557
Phenotype_assayTreatmentQuantified developmental timing using body length over time.Paper_evidenceWBPaper00029007
Curator_confirmedWBPerson557
WBPhenotype:0001384Paper_evidenceWBPaper00029007
Curator_confirmedWBPerson557
WBPhenotype:0001700Paper_evidenceWBPaper00036348
Curator_confirmedWBPerson2021
RemarkThe swim cycles changed in form and were interrupted frequently by uncoordinated movements, for example twisting movements out of the plane of swimming and kinking or curling.Paper_evidenceWBPaper00036348
Curator_confirmedWBPerson2021
WBPhenotype:0001739Paper_evidenceWBPaper00036348
Curator_confirmedWBPerson2021
RemarkMutants showed a reduction in age-related decline as demonstrated by vigorous swimming late in life. Older day 16 rsks-1(ok1255) animals showed significantly less increase in swim cycle duration than wild-typePaper_evidenceWBPaper00036348
Curator_confirmedWBPerson2021
Phenotype_not_observedWBPhenotype:0001273Paper_evidenceWBPaper00029007
Curator_confirmedWBPerson557
RemarkMeasured thermotolerance.Paper_evidenceWBPaper00029007
Curator_confirmedWBPerson557
Phenotype_assayTreatmentthermotolerance measured as survival time at 35 CPaper_evidenceWBPaper00029007
Curator_confirmedWBPerson557
ReferenceWBPaper00039835
WBPaper00029007
WBPaper00036348
WBPaper00065803
Remarkok1255 is a 1700bp deletionPaper_evidenceWBPaper00050108
Sequenced ok1255 mutation in VB1479 to determine exact coordinates of deletion.Person_evidenceWBPerson14863
Curator_confirmedWBPerson51134
Variation information submitted by WBPerson14863 on 2023-11-9_12:08:47 via the Allele submission form.Curator_confirmedWBPerson51134
MethodDeletion_allele