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WormBase Tree Display for Variation: WBVar00095129

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Name Class

WBVar00095129EvidencePaper_evidenceWBPaper00002980
NamePublic_namep811
Other_nameR31.3.1:c.31-1G>A
HGVSgCHROMOSOME_V:g.11927329C>T
Sequence_detailsSMapS_parentSequenceF58H1
Flanking_sequencesgttttcgcattttattatttccattttccaaaccggagtattgggagaaaagttctgatt
Mapping_targetF58H1
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00002980
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00030796
WBStrain00034401
LaboratoryPR
StatusLive
AffectsGeneWBGene00003886
TranscriptR31.3.1VEP_consequencesplice_acceptor_variant
VEP_impactHIGH
HGVScR31.3.1:c.31-1G>A
Intron_number2/12
InteractorWBInteraction000518707
GeneticsInterpolated_map_positionV3.54269
Mapping_dataIn_2_point371
372
792
3383
In_multi_point724
1174
2124
2125
2126
2127
2128
2129
In_pos_neg_data6115
6116
DescriptionPhenotypeWBPhenotype:0000013Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkDaf-dPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000033Paper_evidenceWBPaper00051068
Curator_confirmedWBPerson7188
RemarkFigure 2. Population density-dependent acceleration of development (Pdda) is increased.Paper_evidenceWBPaper00051068
Curator_confirmedWBPerson7188
WBPhenotype:0000249Paper_evidenceWBPaper00000082
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkAnimals did not avoid high concentrations of fructose of NaCl.Paper_evidenceWBPaper00000082
Curator_confirmedWBPerson712
fails to avoid 4M fructose or 4M NaClPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00000082
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00002899Paper_evidenceWBPaper00000082
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBMol:00003571Paper_evidenceWBPaper00000082
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES1_Very_hard_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000263Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkseverely shortened axonemesPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000310Paper_evidenceWBPaper00035062
Curator_confirmedWBPerson2021
RemarkThe ASER neuron lacks ciliary projections in osm-5(p813) and osm-6(p811) IFT mutantsPaper_evidenceWBPaper00035062
Curator_confirmedWBPerson2021
WBPhenotype:0000436Paper_evidenceWBPaper00035062
Curator_confirmedWBPerson2021
RemarkCHE-11:GFP fails to accumulate at the transition zone of osm-5 mutantsPaper_evidenceWBPaper00035062
Curator_confirmedWBPerson2021
WBPhenotype:0000505Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
RemarkFITC occasionally stains ray sensilla.Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
WBPhenotype:0000523Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
RemarkWhile N2 animals traveling perpendicular to the NaCl attractant followed a path that curved with a bias toward the attractant, mutant animals did not regulate their turning; however, like wild-type animals curving decreased over time.Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
WBPhenotype:0000615Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
RemarkDistal and middles segments of all cilia are absent.Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
WBPhenotype:0000649Paper_evidenceWBPaper00003680
Curator_confirmedWBPerson712
Remarkmales are defective in vulva-location behaviorPaper_evidenceWBPaper00003680
Curator_confirmedWBPerson712
WBPhenotype:0000816Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkEctopic assembly of ciliary structures and microtubules in many sensory neurons.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005759PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000843Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
RemarkMating efficiency 1; less than 1% of WT mating efficiency.Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
Phenotype_assayGenotypehim-5(e1490)Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
WBPhenotype:0001084Paper_evidenceWBPaper00000932
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkAnimals do not respond to a dilute gradient of NaCl.Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
poor chemotaxis to NaClPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001435Paper_evidenceWBPaper00002087
Curator_confirmedWBPerson48
RemarkChemotaxis frequency 0.02 versus 0.71 for N2.Paper_evidenceWBPaper00002087
Curator_confirmedWBPerson48
WBPhenotype:0001438Paper_evidenceWBPaper00001786
Curator_confirmedWBPerson2021
RemarkDefective in chemotaxis to volatile odorants including benzaldehyde, 2-butanone and isoamyl alcohol (Data not shown).Paper_evidenceWBPaper00001786
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00001786
Curator_confirmedWBPerson2021
WBPhenotype:0001524Paper_evidenceWBPaper00035944
Curator_confirmedWBPerson2776
WBPerson10038
RemarkQuoted from the paper: "The quiescence bouts in the nmr-1(ak4);osm-6(p811) mutants were significantly longer than either of the single mutants alone (Figure 2B, Table 1). This additive role of nmr-1 and osm-6 is consistent with two independent pathways of quiescence maintenance."Paper_evidenceWBPaper00035944
Curator_confirmedWBPerson10038
WBPhenotype:0001530Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
RemarkFITC occasionally stains CEP.Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
WBPhenotype:0001535Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
RemarkFITC occasionally stains ADE or PDE.Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
WBPhenotype:0001715Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
RemarkAnimals did not exhibit any pirouette-mediated reversal bias in response to a food gradient, unlike control animals, which regulated reversals as a function of direction.Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
WBPhenotype:0002000Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
RemarkAfter exhibiting a greater increase in movement on food (induced by transferring a seeded plate to a multi-worm tracker (MWT) apparatus) than N2, the population of animals also returned to their basal level of spontaneous locomotion speed on food at a faster rate.Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
WBPhenotype:0002053Paper_evidenceWBPaper00055368
Curator_confirmedWBPerson466
Remarksurvive 10nM ivermectinPaper_evidenceWBPaper00055368
Curator_confirmedWBPerson466
Affected_byMoleculeWBMol:00002786Paper_evidenceWBPaper00055368
Curator_confirmedWBPerson466
WBPhenotype:0002114Paper_evidenceWBPaper00035944
Curator_confirmedWBPerson2776
WBPhenotype:0002140Paper_evidenceWBPaper00032050
Curator_confirmedWBPerson712
RemarkAnimals were defective in response to ascr#3, an ascaroside, that elicited the strongest response for male attraction in control animals.Paper_evidenceWBPaper00032050
Curator_confirmedWBPerson712
WBPhenotype:0002469Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
RemarkAnimals exhibited an increase in habituation and much smaller reversal distances in response to continued plate taps applied with a 10s interval, compared to N2 animals.Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
WBPhenotype:0002535Paper_evidenceWBPaper00002087
WBPaper00000932
Person_evidenceWBPerson261
Curator_confirmedWBPerson48
WBPerson712
RemarkDefects in dye filling.Paper_evidenceWBPaper00002087
Curator_confirmedWBPerson48
FITC does not stain amphids or phasmids.Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
fails to take up FITCPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0004004Paper_evidenceWBPaper00003680
Curator_confirmedWBPerson712
Remarkmales are response defectivePaper_evidenceWBPaper00003680
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000067Paper_evidenceWBPaper00003582
Curator_confirmedWBPerson712
Remarkmutants showed a normal feeding inhibition response when exposed to either cadmium or captanPaper_evidenceWBPaper00003582
Curator_confirmedWBPerson712
WBPhenotype:0000315Paper_evidenceWBPaper00000932
WBPaper00000082
Curator_confirmedWBPerson712
RemarkAnimals showed normal sensitivity to light head and tail tapping with a human eyelash.Paper_evidenceWBPaper00000082
Curator_confirmedWBPerson712
WBPhenotype:0000478Paper_evidenceWBPaper00000932
WBPaper00000082
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkAnimals were able to track isothermally.Paper_evidenceWBPaper00000082
Curator_confirmedWBPerson712
normal thermotaxisPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000643Paper_evidenceWBPaper00000082
Curator_confirmedWBPerson712
RemarkAnimals moved normally.Paper_evidenceWBPaper00000082
Curator_confirmedWBPerson712
WBPhenotype:0001015Paper_evidenceWBPaper00000082
Curator_confirmedWBPerson712
RemarkAnimals did not display any major developmental defects compared to N2 animals.Paper_evidenceWBPaper00000082
Curator_confirmedWBPerson712
WBPhenotype:0001660Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
RemarkNo disruption of ASE asymmetry (as seen with lim-6 reporters)Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
Phenotype_assayGenotypeotIs114, otIs6Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
WBPhenotype:0001765Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
RemarkMutants respond normally to CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Phenotype_assayTreatment10% CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
WBPhenotype:0004027Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
RemarkAnimals exhibit an escape response (reversal) similar to N2 animals upon an initial plate tap.Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
Reference (21)
RemarkVariation stub/paper connection generated from the May 2021 NN VFP dataset.
Created by WBPerson51134 from the NN_VFP_triage_pipeline
MethodSubstitution_allele