WormBase Tree Display for Variation: WBVar00142871

WBVar00142871 Name: Public_name: dv38
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00005059
    Laboratory: CL
    Status: Live
  Affects: Gene: WBGene00005157
    Interactor: WBInteraction000052126
  Genetics: Mapping_data: In_2_point: 5510
      In_multi_point: 1587
        1859
        1860
      In_pos_neg_data: 4515
        5508
        5509
  Description: Phenotype: WBPhenotype:0000006 Paper_evidence: WBPaper00001576
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited a progressive egg-laying defect as assayed by in increase in bloated animals in the population over days post L4-adult molt. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001576
                Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0000014 Paper_evidence: WBPaper00001576
        Curator_confirmed: WBPerson712
        Remark: Commissures crossed or fasciculated with neighboring commissures. As assayed on fixed animals stained with anti-GABA anti-sera. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0000070 Paper_evidence: WBPaper00001576
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Males exhibit abnormal copulatory bursae characterized by a reduced fan and a swollen bursa. In addition, the ray were generally shortened although were of the correct number, as determined by DIC microscopy. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00001576
                Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0000195 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Mig(DTC) Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0006865 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
      WBPhenotype:0000309 Paper_evidence: WBPaper00001576
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Dauer larva do not survive 1-hr treatment in 1% SDS. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0000443 Paper_evidence: WBPaper00001576
        Curator_confirmed: WBPerson712
        Remark: Copulatory spicules were commonly crumpled or malformed, as determined by DIC microscopy. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00001576
                Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0000569 Paper_evidence: WBPaper00001576
        Curator_confirmed: WBPerson712
        Remark: The cord commissures have many more varicosities than wild-type animals and are also more likely to cross or fasciculate with neighboring commissures, as assayed on fixed animals stained with anti-GABA anti-sera. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0000640 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00001576
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: The uncoordinated phenotype is characterized by slow movement, occasionally nonsinusoidal body posture and a distinctive "head-waving" backwards movement displayed when the animals are prodded at the head. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0000700 Paper_evidence: WBPaper00001576
        Curator_confirmed: WBPerson712
        Remark: 4/502 (0.8%) animals are Muv. Muv has weak expressivity; however becomes more dramatic when mutant is combined with lin-12(n302). Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Penetrance: Low: Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0000816 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: variable neuronal abnormalities Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001068 Paper_evidence: WBPaper00001576
        Curator_confirmed: WBPerson712
        Remark: Animals have reduced sensitivity to exgenous serotonin. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00004929 Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001576
                Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0001340 Paper_evidence: WBPaper00001576
        Curator_confirmed: WBPerson712
        Remark: Animals have reduced sensitivity to exgenous imiprimine. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001576
                Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0001355 Paper_evidence: WBPaper00001576
        Curator_confirmed: WBPerson712
        Remark: Animals exhibit 'ventralized' gonads to a less severe degree than unc-6 mutants. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: 100 young adult animals were scored by DIC optics at 400X. Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
          Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0001411 Paper_evidence: WBPaper00001576
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Animals exhibit consistent WGA lectin binding, unlike normal animals. Ectopic lectin-binding was hightly penetrant in both males and hermaphrodites with more intensive posterior staing in males. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
          altered cuticle labelling, ectopic WGA lectin binding Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Penetrance: High: Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00005277 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Ectopic surface binding of WGA lectin was initially assayed through binding of biotinylated-WGA/avidin-horseradish peroxidase (detailed in materials and methods) as well as by WGA-FITC staining. Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
          Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0001420 Paper_evidence: WBPaper00031925
        Curator_confirmed: WBPerson712
        Remark: Animals exhibit partial resistance to the attachment of biofilm produced by Xenorhabdus nematophila. Paper_evidence: WBPaper00031925
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00031925
              Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Biofilm formation on adult worms was assessed for worms incubated 24-48 hours on the bacterial lawn. Alternatively, gravid adults were allowed to lay eggs on bacterial lawns for several hours, then removed and larvae were assessed for biofilm attachment the next day. Paper_evidence: WBPaper00031925
              Curator_confirmed: WBPerson712
      WBPhenotype:0002491 Paper_evidence: WBPaper00001576
        Curator_confirmed: WBPerson712
        Remark: ALM neurons exhibited posteriorly-directed axonal projections. As scored by epifluroescence microscopy on fixed animals stained with antibody 6-11B-1. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005406 PATO:0000460 Paper_evidence: WBPaper00001576
                Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000603 Paper_evidence: WBPaper00001576
        Curator_confirmed: WBPerson712
        Remark: Muscle fiber organization and muscle cell arrangement appeared generally wild-type. Paper_evidence: WBPaper00001576
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001576
          Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: him-5(e1490) Paper_evidence: WBPaper00001576
              Curator_confirmed: WBPerson712
      WBPhenotype:0001420 Paper_evidence: WBPaper00029153
        Curator_confirmed: WBPerson712
  Reference: WBPaper00001576
    WBPaper00031925
    WBPaper00029153
    WBPaper00014307
  Method: Allele