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WormBase Tree Display for Variation: WBVar00142944

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Name Class

WBVar00142944NamePublic_namee66
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (12)
LaboratoryCB
StatusLive
AffectsGeneWBGene00006759
InteractorWBInteraction000518532
WBInteraction000518533
WBInteraction000538532
GeneticsMapping_dataIn_2_point96
102
113
118
837
3263
4987
7046
7047
In_multi_point (25)
In_pos_neg_data829
4676
4690
DescriptionPhenotypeWBPhenotype:0000001Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkunable to hypercontractPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000164Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkthinPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000273Paper_evidenceWBPaper00046636
Curator_confirmedWBPerson557
WBPhenotype:0000421Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkunable to hypercontract and therefore levamisole resistantPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000422Paper_evidenceWBPaper00000031
WBPaper00037063
Person_evidenceWBPerson261
Curator_confirmedWBPerson48
WBPerson712
Remarktwitcher at all stages; (moves slowly with constant trembling); e66/+ twitches in 1% nicotinePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
unc-22 mutants have a spontaneous twitcher phenotype; at 25C the majority of the unc-22(e66) mutant worms have a more severe paralysis phenotype.Paper_evidenceWBPaper00037063
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00037063
Curator_confirmedWBPerson712
Ease_of_scoringES3_Easy_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000509Paper_evidenceWBPaper00000536
Curator_confirmedWBPerson712
RemarkOnly 10% of sperm have pseudopods, all of which have normal morphology.Paper_evidenceWBPaper00000536
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006798PATO:0000460Paper_evidenceWBPaper00000536
Curator_confirmedWBPerson712
WBPhenotype:0001203Paper_evidenceWBPaper00046636
Curator_confirmedWBPerson557
Phenotype_assayTreatmentAnimals exposed to a solution of 0.1 percent nicotine.Paper_evidenceWBPaper00046636
Curator_confirmedWBPerson557
WBPhenotype:0001852Paper_evidenceWBPaper00035074
Curator_confirmedWBPerson2021
RemarkMutants are resistant to tribendimidinePaper_evidenceWBPaper00035074
Curator_confirmedWBPerson2021
WBPhenotype:0001889Paper_evidenceWBPaper00046636
Curator_confirmedWBPerson557
RemarkSarcomeres are disorganized in unc-22(e66). To examine sarcomere morphology the authors looked at the localization of the following proteins: UNC-95, ATN-1, UNC-89, MHC A and MHC B. Antibodies to all these proteins showed abnormal localization.Paper_evidenceWBPaper00046636
Curator_confirmedWBPerson557
Phenotype_not_observedWBPhenotype:0000195Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Remark"Mutations in unc-22 or unc-54 that disrupt the function and structure of body wall muscles (Moerman et al., 1986) had no significant effect on the frequency of DTC migration defects (Table 1; P > 0.3)."Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006865PATO:0000460Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Phenotype_assayGenotypeunc-5(e152)Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Reference (14)
RemarkVariation stub/paper connection generated from the May 2021 NN VFP dataset.
Created by WBPerson51134 from the NN_VFP_triage_pipeline
MethodAllele