WormBase Tree Display for Variation: WBVar00142944
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WBVar00142944 | Name | Public_name | e66 | ||||||
---|---|---|---|---|---|---|---|---|---|
Sequence_details | SeqStatus | Pending_curation | |||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain (12) | |||||||||
Laboratory | CB | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00006759 | |||||||
Interactor | WBInteraction000518532 | ||||||||
WBInteraction000518533 | |||||||||
WBInteraction000538532 | |||||||||
Genetics | Mapping_data | In_2_point | 96 | ||||||
102 | |||||||||
113 | |||||||||
118 | |||||||||
837 | |||||||||
3263 | |||||||||
4987 | |||||||||
7046 | |||||||||
7047 | |||||||||
In_multi_point (25) | |||||||||
In_pos_neg_data | 829 | ||||||||
4676 | |||||||||
4690 | |||||||||
Description | Phenotype | WBPhenotype:0000001 | Person_evidence | WBPerson261 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | unable to hypercontract | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000164 | Person_evidence | WBPerson261 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | thin | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000273 | Paper_evidence | WBPaper00046636 | |||||||
Curator_confirmed | WBPerson557 | ||||||||
WBPhenotype:0000421 | Person_evidence | WBPerson261 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | unable to hypercontract and therefore levamisole resistant | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000422 | Paper_evidence | WBPaper00000031 | |||||||
WBPaper00037063 | |||||||||
Person_evidence | WBPerson261 | ||||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPerson712 | |||||||||
Remark | twitcher at all stages; (moves slowly with constant trembling); e66/+ twitches in 1% nicotine | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
unc-22 mutants have a spontaneous twitcher phenotype; at 25C the majority of the unc-22(e66) mutant worms have a more severe paralysis phenotype. | Paper_evidence | WBPaper00037063 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Temperature_sensitive | Heat_sensitive | 25 | Paper_evidence | WBPaper00037063 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Ease_of_scoring | ES3_Easy_to_score | Person_evidence | WBPerson261 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000509 | Paper_evidence | WBPaper00000536 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Only 10% of sperm have pseudopods, all of which have normal morphology. | Paper_evidence | WBPaper00000536 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006798 | PATO:0000460 | Paper_evidence | WBPaper00000536 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001203 | Paper_evidence | WBPaper00046636 | |||||||
Curator_confirmed | WBPerson557 | ||||||||
Phenotype_assay | Treatment | Animals exposed to a solution of 0.1 percent nicotine. | Paper_evidence | WBPaper00046636 | |||||
Curator_confirmed | WBPerson557 | ||||||||
WBPhenotype:0001852 | Paper_evidence | WBPaper00035074 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Mutants are resistant to tribendimidine | Paper_evidence | WBPaper00035074 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0001889 | Paper_evidence | WBPaper00046636 | |||||||
Curator_confirmed | WBPerson557 | ||||||||
Remark | Sarcomeres are disorganized in unc-22(e66). To examine sarcomere morphology the authors looked at the localization of the following proteins: UNC-95, ATN-1, UNC-89, MHC A and MHC B. Antibodies to all these proteins showed abnormal localization. | Paper_evidence | WBPaper00046636 | ||||||
Curator_confirmed | WBPerson557 | ||||||||
Phenotype_not_observed | WBPhenotype:0000195 | Paper_evidence | WBPaper00005809 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Mutations in unc-22 or unc-54 that disrupt the function and structure of body wall muscles (Moerman et al., 1986) had no significant effect on the frequency of DTC migration defects (Table 1; P > 0.3)." | Paper_evidence | WBPaper00005809 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006865 | PATO:0000460 | Paper_evidence | WBPaper00005809 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
GO_term | GO:0016477 | PATO:0000460 | Paper_evidence | WBPaper00005809 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
Phenotype_assay | Genotype | unc-5(e152) | Paper_evidence | WBPaper00005809 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
Reference (14) | |||||||||
Remark | Variation stub/paper connection generated from the May 2021 NN VFP dataset. | ||||||||
Created by WBPerson51134 from the NN_VFP_triage_pipeline | |||||||||
Method | Allele |