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WormBase Tree Display for Variation: WBVar00144038

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Name Class

WBVar00144038EvidencePaper_evidenceWBPaper00026986
NamePublic_namee1489
Other_nameT07G12.12a.1:c.775G>A
CE36715:p.Gly259Arg
HGVSgCHROMOSOME_IV:g.10563247G>A
Sequence_detailsSMapS_parentSequenceT07G12
Flanking_sequencesaatcgagcaattgcgtggaagaggaaatatgaaaacttcgtcttatcgatcacgcattgg
Mapping_targetT07G12
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00026986
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (127)
LaboratoryCB
NFB
OH
CHB
StatusLive
AffectsGeneWBGene00001867
TranscriptT07G12.12a.1 (12)
GeneticsInterpolated_map_positionIV4.63927
Mapping_dataIn_2_point317
In_multi_point (12)
In_pos_neg_data (5)
DescriptionPhenotypeWBPhenotype:0000583Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
RemarkAnimals segregate 5% XXX (Dumpy) progeny.Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
PenetranceLowPaper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
WBPhenotype:0000742Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkAnimals exhibit reduced recombination (9%) compared to wild type.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000863Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkMales exhibit 8.8% wild type fertility.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0001175Paper_evidenceWBPaper00001077
WBPaper00000565
WBPaper00000179
WBPaper00048917
Person_evidenceWBPerson136
WBPerson261
Curator_confirmedWBPerson48
WBPerson712
WBPerson721
RemarkLittle or no autosomal missegregation.Person_evidenceWBPerson136
Curator_confirmedWBPerson48
Male self-progeny make up 30.3% population as measured from 8 broods, 895 total animals.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Animals segregate 36.7% males compared to 0.3% segregated by wild type animals.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
Self-progeny 37% XO male, 6% 3X herm, 38% nullo-X ova as a result of reductional meiotic nondisjunction X chromosome recombination specifically reduced 90% except at left end (increased). Easy to score (ES3) as progeny.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
PenetranceIncompletePerson_evidenceWBPerson136
Curator_confirmedWBPerson48
31%Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
Range3939Person_evidenceWBPerson136
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson136
Curator_confirmedWBPerson48
Ease_of_scoringES3_Easy_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001583Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkAnimals segregate a small percentage (6.4%) of short animals shown to be 3X hermaphrodites (wild type segregates 0.04% 3X herm.).Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000050Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
Remark0.8% eggs never hatch, yet are refractile, similar in percent to those from wild type animals.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000062Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
RemarkAnimals produce 4% dead embryos and L1 (n=1597), not unlike wild type, which produce 2% dead L1 (n=1755).Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
WBPhenotype:0000143Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTreatmentUV sensitivities were measured as % survival based on radiation dose. Alkaline bleach isolated eggs ranging in age from 30-180 minutes were aliquoted to plates to give between 25-300 survivors/plate. The plated eggs were irradiated at different doses at a rate of 1Jm 10X-2/sec. Irradiated animals were protected from light. Survival was scored as the % animals reaching adulthood 4-6 days after irradiation relative to un-irradiated controls.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000154Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkAnimals have an average brood size of 30237 s.d. (6 broods counted), wild type has average brood size 33034 s.d. (8 broods counted).Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000276Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTreatmentX-ray sensitivities were measured as % survival based on radiation dose. Alkaline bleach isolated eggs ranging in age from 30-180 minutes were aliquoted to plates to give between 25-300 survivors/plate. The plated eggs were irradiated at different doses at a rate of 470 r/min. Survival was scored as the % animals reaching adulthood 4-6 days after irradiation relative to un-irradiated controls.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000517Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkAnimals are indistinguishable from wild type in terms of behavior.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000520Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkBoth hermaphrodites and males are indistinguishable from wild type in terms of superficial anatomy.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000673Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
RemarkAverage brood size 254 38 (n=1597)Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
WBPhenotype:0001631Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkThe sex ratio of cross progeny sired by him males does not significantly differ from 1:1.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0002140Paper_evidenceWBPaper00032050
Curator_confirmedWBPerson712
RemarkMales responded to ascr#3, an ascaroside, in male attraction assays.Paper_evidenceWBPaper00032050
Curator_confirmedWBPerson712
ReferenceWBPaper00029013
WBPaper00001077
WBPaper00000565
WBPaper00014382
WBPaper00014652
WBPaper00016084
WBPaper00003744
WBPaper00016411
WBPaper00026552
WBPaper00000179
WBPaper00010692
WBPaper00026418
WBPaper00015605
WBPaper00015424
WBPaper00014771
WBPaper00032050
WBPaper00016558
WBPaper00025945
WBPaper00016248
WBPaper00014495
WBPaper00014655
WBPaper00014496
WBPaper00048917
WBPaper00061034
WBPaper00065281
WBPaper00065258
WBPaper00065293
WBPaper00065747
WBPaper00065979
RemarkAllele incorrectly cited as e1389Paper_evidenceWBPaper00003393
Allele incorrectly cited as e2489Paper_evidenceWBPaper00003294
Variation stub/paper connection generated from the May 2021 NN VFP dataset.
Created by WBPerson51134 from the NN_VFP_triage_pipeline
MethodSubstitution_allele