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WormBase Tree Display for Variation: WBVar00145482

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Name Class

WBVar00145482NamePublic_namegk27
Other_nameC04F6.4a.1:c.301_624delinsTTCCGAACACA
CE03924:p.Val101PhefsTer29
HGVSgCHROMOSOME_X:g.3410168_3410919delinsTGTGTTCGGAA
Sequence_detailsSMapS_parentSequenceC04F6
Flanking_sequencesgttgtataacacaatggttccatctcctcccggaatagtagttttcagaatgtgggtggt
Mapping_targetC04F6
Type_of_mutationInsertiontgtgttcggaa
Deletion
PCR_productGK27_external
GK27_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00035493
LaboratoryVC
PersonWBPerson427
KO_consortium_allele
StatusLive
AffectsGeneWBGene00006810
TranscriptC04F6.4a.1 (11)
InteractorWBInteraction000501690
WBInteraction000502344
WBInteraction000542289
WBInteraction000542290
WBInteraction000542291
IsolationMutagenUV/TMP
DescriptionPhenotypeWBPhenotype:0000436Paper_evidenceWBPaper00032338
Curator_confirmedWBPerson712
RemarkTMD-1 mislocalized to actin aggregates in body wall muscles based on immunolocalization of TMD-1 and UNC-60B.Paper_evidenceWBPaper00032338
Curator_confirmedWBPerson712
WBPhenotype:0001206Paper_evidenceWBPaper00032338
Curator_confirmedWBPerson712
RemarkAnimals exhibited a lower frequency of head movements in liquid compared to wild-type animals.Paper_evidenceWBPaper00032338
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAdult worms were placed in M9 buffer. Then, one beat was counted when a worm swung its head to either the right or left. The total number of beats in 30 seconds was recorded. Worm motility was quantified as described previously (Epstein and Thomson, 1974). Animals were treated with control dsRNA.Paper_evidenceWBPaper00032338
Curator_confirmedWBPerson712
WBPhenotype:0001587Paper_evidenceWBPaper00032338
Curator_confirmedWBPerson712
RemarkF-actin aggregated in body wall muscle.Paper_evidenceWBPaper00032338
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00032338
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006804PATO:0000460Paper_evidenceWBPaper00032338
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAdult worms treated with control dsRNA were stained with tetramethyl-Rhodamine-phalloidin, and worms with actin aggregates in their muscle were scored.Paper_evidenceWBPaper00032338
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0001652Paper_evidenceWBPaper00032446
Curator_confirmedWBPerson2021
ReferenceWBPaper00032446
WBPaper00032338
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele