WormBase Tree Display for Variation: WBVar00146378

WBVar00146378 Evidence: Paper_evidence: WBPaper00025221
  Name: Public_name: gu22
    Other_name: CE05215:p.Met57Ile
      C04G2.7.1:c.171G>A
    HGVSg: CHROMOSOME_IV:g.10109232C>T
  Sequence_details: SMap: S_parent: Sequence: C04G2
    Flanking_sequences: tgacacagttcgtgctcaaatagtcgaaat tcacaacatggtacacgaccatgtgacata
    Mapping_target: C04G2
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00025221
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: CM
    Status: Live
  Affects: Gene: WBGene00001204
    Transcript: C04G2.7.1 (12)
  Genetics: Interpolated_map_position: IV 4.52959
  Description: Phenotype: WBPhenotype:0000183 Paper_evidence: WBPaper00028561
        Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005784 PATO:0000460 Paper_evidence: WBPaper00028561
                Curator_confirmed: WBPerson712
          Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00028561
                Curator_confirmed: WBPerson712
      WBPhenotype:0001180 Paper_evidence: WBPaper00028561
        Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005784 PATO:0000460 Paper_evidence: WBPaper00028561
                Curator_confirmed: WBPerson712
          Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00028561
                Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Germline corpses were quantified in staged adults (generally 24 hours after L4/adult molt) stained with SYTO12. Paper_evidence: WBPaper00028561
              Curator_confirmed: WBPerson712
      WBPhenotype:0001278 Paper_evidence: WBPaper00025221
        Curator_confirmed: WBPerson2021
        Remark: gu22 affected the expression of lin-48 in hindgut cells Paper_evidence: WBPaper00025221
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00025221
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: saIs14 [lin-48::GFP] Paper_evidence: WBPaper00025221
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001297 Paper_evidence: WBPaper00025221
        Curator_confirmed: WBPerson2021
        Remark: gu22 mutants exhibit defective male tail development Paper_evidence: WBPaper00025221
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00025221
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001298 Paper_evidence: WBPaper00025221
        Curator_confirmed: WBPerson2021
        Remark: gu22 mutants exhibit defective hindgut development Paper_evidence: WBPaper00025221
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00025221
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001372 Paper_evidence: WBPaper00025221
        Curator_confirmed: WBPerson2021
        Remark: gu22 protein exhibits reduced DNA binding activity Paper_evidence: WBPaper00025221
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00025221
            Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000006 Paper_evidence: WBPaper00025221
        Curator_confirmed: WBPerson2021
        Remark: Mutants retain a high level of function in the egg-laying system Paper_evidence: WBPaper00025221
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00025221
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000695 Paper_evidence: WBPaper00025221
        Curator_confirmed: WBPerson2021
        Remark: vulF morphogenesis is normal Paper_evidence: WBPaper00025221
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00025221
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006768 PATO:0000460 Paper_evidence: WBPaper00025221
                Curator_confirmed: WBPerson2021
  Reference: WBPaper00028561
    WBPaper00025221
  Method: Substitution_allele