WormBase Tree Display for Variation: WBVar00241424

WBVar00241424 Name: Public_name: r896
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00004568
      WBStrain00034945
    Laboratory: TR
    Status: Live
  Affects: Gene: WBGene00004884
    Interactor: WBInteraction000519062
      WBInteraction000519074
  Genetics: Mapping_data: In_2_point: 4700
        6023
      In_multi_point: 1633
        2037
        2038
        2039
      In_pos_neg_data: 5996
  Description: Phenotype: WBPhenotype:0000506 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: adult male has swollen bursa Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000508 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: unc-54 nonsense RNAs accumulate. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000697 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: adult hermaphrodite has protruding vulva Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001538 Paper_evidence: WBPaper00001192
          WBPaper00001813
        Curator_confirmed: WBPerson2021
        Remark: Isolated as a suppressor of unc-54(r293). This allele exhibits morphological abnormalities in the genitalia. Suppresses paralysis in unc-54(r293), sterility in tra-2(e1209), Egl and alae defects in lin-29(n546) and Dpy phenotype in dpy-5(e61). The unc-54 and lin-29 phenotypes were suppressed with maternal effect. Paper_evidence: WBPaper00001192
            Curator_confirmed: WBPerson2021
          Increases the steady state level of unc-54 mutant mRNAs (altered 3' UTR and nonsense mutations). Paper_evidence: WBPaper00001813
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001192
            WBPaper00001813
          Curator_confirmed: WBPerson2021
      WBPhenotype:0001828 Paper_evidence: WBPaper00004325
        Curator_confirmed: WBPerson2021
        Remark: Mutant smg-6 animals recovered rapidly from unc-54 RNAi-induced paralysis, unlike wild-type Paper_evidence: WBPaper00004325
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: RNAi injection Paper_evidence: WBPaper00004325
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00014397
    WBPaper00004325
    WBPaper00001192
    WBPaper00014396
    WBPaper00001813
    WBPaper00013850
    WBPaper00020795
    WBPaper00014682
  Method: Allele