WormBase Tree Display for Variation: WBVar00241641

WBVar00241641 Evidence: Paper_evidence: WBPaper00032102
  Name: Public_name: rt142
  Sequence_details: Mapping_target: F11C7
    Type_of_mutation: Deletion
    SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00008296
    Laboratory: HA
    Status: Live
  Affects: Gene: WBGene00003891
    Interactor: WBInteraction000500645
      WBInteraction000500647
      WBInteraction000500648
      WBInteraction000500649
      WBInteraction000500655
      WBInteraction000500656
      WBInteraction000500658
      WBInteraction000500659
      WBInteraction000500660
  Isolation: Mutagen: EMS Paper_evidence: WBPaper00032102
  Description: Phenotype: WBPhenotype:0000071 Paper_evidence: WBPaper00032102
        Curator_confirmed: WBPerson2021
        Remark: osm-11(lf) animals had defects in head morphology at low frequency Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        Penetrance: Low: Paper_evidence: WBPaper00032102
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032102
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005739 PATO:0000460 Paper_evidence: WBPaper00032102
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000220 Paper_evidence: WBPaper00032102
        Curator_confirmed: WBPerson2021
        Remark: Loss of osm-11 perturbs secondary vulval cell fate specification assayed via egl-17, lip-1 and lin-11 expression Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        Penetrance: Incomplete: Paper_evidence: WBPaper00032102
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032102
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0008121 PATO:0000460 Paper_evidence: WBPaper00032102
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000035 PATO:0000460 Paper_evidence: WBPaper00032102
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000315 Paper_evidence: WBPaper00038400
        Curator_confirmed: WBPerson712
        Remark: Animals had a lower arousal threshold to mechanosensory stimuli than control animals; animals responded more frequently to stimuli than control quiescent animals. Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
      WBPhenotype:0000412 Paper_evidence: WBPaper00038400
        Curator_confirmed: WBPerson712
        Remark: Animals took significantly more time to respond to octanol (initiate backwards movement) than WT controls. This defect was rescued by conditional expression of OSM-11 after cell fate specification was complete. This defect is also rescued by OSM-11 expression in seam cells and hypodermal tissues. Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00001966 Paper_evidence: WBPaper00038400
              Curator_confirmed: WBPerson712
      WBPhenotype:0000545 Paper_evidence: WBPaper00032102
        Curator_confirmed: WBPerson2021
        Remark: Animals inappropriately retained eggs Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        Penetrance: Incomplete: 57 percent Paper_evidence: WBPaper00032102
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032102
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00032102
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000641 Paper_evidence: WBPaper00038400
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited increased basal locomotion activity, twice the number of body bends per minute than observed for control animals. Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
      WBPhenotype:0000695 Paper_evidence: WBPaper00032102
        Curator_confirmed: WBPerson2021
        Remark: The majority of animals lacking osm-11 had visibly misshapen vulva Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        Penetrance: Incomplete: 15 percent Paper_evidence: WBPaper00032102
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032102
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00032102
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00032102
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000697 Paper_evidence: WBPaper00032102
        Curator_confirmed: WBPerson2021
        Penetrance: Incomplete: 42 percent Paper_evidence: WBPaper00032102
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032102
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00032102
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000700 Paper_evidence: WBPaper00032102
        Curator_confirmed: WBPerson2021
        Remark: Extra protrusion near the normally positioned vulva Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        Penetrance: Incomplete: 12 percent Paper_evidence: WBPaper00032102
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032102
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00032102
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000876 Paper_evidence: WBPaper00032102
        Curator_confirmed: WBPerson712
        Remark: Animals are motile on 500mM NaCl NGM plates. Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00032102
          Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson712
      WBPhenotype:0000907 Paper_evidence: WBPaper00032102
        Curator_confirmed: WBPerson2021
        Remark: Animals had a ventral protrusion behind the anus Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        Penetrance: Incomplete: 66 percent Paper_evidence: WBPaper00032102
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032102
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005364 PATO:0000460 Paper_evidence: WBPaper00032102
                Curator_confirmed: WBPerson2021
      WBPhenotype:0001040 Paper_evidence: WBPaper00032102
        Curator_confirmed: WBPerson712
        Remark: osm-11(rt142) is more severe than rt68. Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00032102
          Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson712
      WBPhenotype:0001418 Paper_evidence: WBPaper00044578
        Curator_confirmed: WBPerson12259
        Remark: Figure 5B Paper_evidence: WBPaper00044578
            Curator_confirmed: WBPerson12259
      WBPhenotype:0001524 Paper_evidence: WBPaper00038400
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited increased L4/A quiescence compared to control animals. Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
      WBPhenotype:0001998 Paper_evidence: WBPaper00038282
        Curator_confirmed: WBPerson712
        Remark: osm-11 mutant survival is low compared to N2 animals after laser ablation of Pn.p cells during the isolation of P4.p. Paper_evidence: WBPaper00038282
            Curator_confirmed: WBPerson712
          Among animals in which one VPC was isolated by laser ablation, the isolated VPC showed a decrease in secondary fate frequency with a corresponding tertiary fate increase. Paper_evidence: WBPaper00038282
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000256 Paper_evidence: WBPaper00038400
        Curator_confirmed: WBPerson712
        Remark: No morphological defects were observed in the octanol-sensing chemosensory amphid neurons (data not shown). Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00038400
            Curator_confirmed: WBPerson712
      WBPhenotype:0001586 Paper_evidence: WBPaper00032102
        Curator_confirmed: WBPerson2021
        Remark: Loss of osm-11 does not alter AC-VU fate specification Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00032102
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00032102
            Curator_confirmed: WBPerson2021
  Reference: WBPaper00038282
    WBPaper00038400
    WBPaper00032102
    WBPaper00044578
  Remark: rt142 removes all of the predicted mature protein Paper_evidence: WBPaper00032102
  Method: Deletion_allele