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WormBase Tree Display for Variation: WBVar00248883

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Name Class

WBVar00248883NamePublic_namesw1
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00007523
LaboratoryFR
StatusLive
AffectsGeneWBGene00000437
InteractorWBInteraction000520432
DescriptionPhenotypeWBPhenotype:0000062Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
RemarkRescued with ceh-13 carried on cosmid PD1.Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
WBPhenotype:0000242Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
Remarksw1 mutants develop normally until the beginning of elongation, when animals elongate to varying degrees before retracting.Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
WBPhenotype:0000409Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
RemarkThe sw1 Vab phenotype is characterized by incompletely penetrant zygotic lethality, with most animals arresting during embryogenesis or at early larval stages with severe morphogenetic defects. Rare survivors have less severe morphogenetic defects than arrested animals, but are smaller and grow slower than wild-type animals. Arrested animals are very short with protuberances in their anterior and occasionally posterior regions. Some animals exhibit a ruptured hypodermis.Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
WBPhenotype:0000736Paper_evidenceWBPaper00038332
Curator_confirmedWBPerson712
RemarkEmbryos exhibit upregulated autophagic activity.Paper_evidenceWBPaper00038332
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003899Paper_evidenceWBPaper00038332
Curator_confirmedWBPerson712
WBPhenotype:0000749Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
RemarkThe division pattern and identity of cells of the pre-bean stage animal appeared to be normal; however, during the comma stage, individual cells, such as neuronal precursor cells as well as hypodermal descendants exhibited, adhesion problems.Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
WBPhenotype:0001005Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
RemarkRare escapers are unable to move backwards although they can move forwards.Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
WBPhenotype:0001062Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
RemarkAnimals may or may not exhibit twitching after elongation. Those that do only exhibit weak twitching as opposed to and increase in twitching and movement as development progresses.Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
WBPhenotype:0001744Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
RemarkHypodermal and body wall muscle cells become mislocalized during embryonic development, as demonstrated by mispositioning of anti-body stained cells compared to control animals.Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000216Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
RemarkHypodermal and mesodermal cell fate appear normal as determined by MH27 and anti-LIN-26 antibody expression patterns as well as anti-myosin heavy chain A antibody staining, which indicated these cells were correctly specified.Paper_evidenceWBPaper00003508
Curator_confirmedWBPerson712
ReferenceWBPaper00038332
WBPaper00003508
WBPaper00011305
WBPaper00019437
MethodAllele