WormBase Tree Display for Variation: WBVar00248883
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WBVar00248883 | Name | Public_name | sw1 | |||||
---|---|---|---|---|---|---|---|---|
Sequence_details | SeqStatus | Pending_curation | ||||||
Variation_type | Allele | |||||||
Origin | Species | Caenorhabditis elegans | ||||||
Strain | WBStrain00007523 | |||||||
Laboratory | FR | |||||||
Status | Live | |||||||
Affects | Gene | WBGene00000437 | ||||||
Interactor | WBInteraction000520432 | |||||||
Description | Phenotype | WBPhenotype:0000062 | Paper_evidence | WBPaper00003508 | ||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Rescued with ceh-13 carried on cosmid PD1. | Paper_evidence | WBPaper00003508 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000242 | Paper_evidence | WBPaper00003508 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | sw1 mutants develop normally until the beginning of elongation, when animals elongate to varying degrees before retracting. | Paper_evidence | WBPaper00003508 | |||||
Curator_confirmed | WBPerson712 | |||||||
Recessive | Paper_evidence | WBPaper00003508 | ||||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000409 | Paper_evidence | WBPaper00003508 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | The sw1 Vab phenotype is characterized by incompletely penetrant zygotic lethality, with most animals arresting during embryogenesis or at early larval stages with severe morphogenetic defects. Rare survivors have less severe morphogenetic defects than arrested animals, but are smaller and grow slower than wild-type animals. Arrested animals are very short with protuberances in their anterior and occasionally posterior regions. Some animals exhibit a ruptured hypodermis. | Paper_evidence | WBPaper00003508 | |||||
Curator_confirmed | WBPerson712 | |||||||
Recessive | Paper_evidence | WBPaper00003508 | ||||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000736 | Paper_evidence | WBPaper00038332 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Embryos exhibit upregulated autophagic activity. | Paper_evidence | WBPaper00038332 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00003899 | Paper_evidence | WBPaper00038332 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000749 | Paper_evidence | WBPaper00003508 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | The division pattern and identity of cells of the pre-bean stage animal appeared to be normal; however, during the comma stage, individual cells, such as neuronal precursor cells as well as hypodermal descendants exhibited, adhesion problems. | Paper_evidence | WBPaper00003508 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001005 | Paper_evidence | WBPaper00003508 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Rare escapers are unable to move backwards although they can move forwards. | Paper_evidence | WBPaper00003508 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001062 | Paper_evidence | WBPaper00003508 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals may or may not exhibit twitching after elongation. Those that do only exhibit weak twitching as opposed to and increase in twitching and movement as development progresses. | Paper_evidence | WBPaper00003508 | |||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001744 | Paper_evidence | WBPaper00003508 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Hypodermal and body wall muscle cells become mislocalized during embryonic development, as demonstrated by mispositioning of anti-body stained cells compared to control animals. | Paper_evidence | WBPaper00003508 | |||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_not_observed | WBPhenotype:0000216 | Paper_evidence | WBPaper00003508 | |||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Hypodermal and mesodermal cell fate appear normal as determined by MH27 and anti-LIN-26 antibody expression patterns as well as anti-myosin heavy chain A antibody staining, which indicated these cells were correctly specified. | Paper_evidence | WBPaper00003508 | |||||
Curator_confirmed | WBPerson712 | |||||||
Reference | WBPaper00038332 | |||||||
WBPaper00003508 | ||||||||
WBPaper00011305 | ||||||||
WBPaper00019437 | ||||||||
Method | Allele |