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WormBase Tree Display for Variation: WBVar00266629

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Name Class

WBVar00266629EvidencePaper_evidenceWBPaper00035070
NamePublic_nameu267
Other_nameCE02308:p.Gly191Glu
T01E8.4.1:c.572G>A
HGVSgCHROMOSOME_II:g.10239069C>T
Sequence_detailsSMapS_parentSequenceT01E8
Flanking_sequencesctgtaaaaagttggcacatcacagataatgagctcttcaaaatcttaattccgtgaatgtt
Mapping_targetT01E8
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00035070
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryTU
StatusLive
AffectsGeneWBGene00003177
TranscriptT01E8.4.1 (12)
InteractorWBInteraction000517353
WBInteraction000517357
GeneticsInterpolated_map_positionII2.31428
DescriptionPhenotypeWBPhenotype:0000315Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
RemarkThis mutation confers partial touch insensitivity. some animals respond to many touches while others fail to respond after a few touches. The severity of the phenotype increases at higher temperatures.Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
WBPhenotype:0000905Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
RemarkAnimals exhibited distorted cell-body morphology; somas were generally larger and misshapen as well as accumulated more jsIs821[RAB-3::GFP] reporter product. This phenotype is stronger at higher temperatures.Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005237PATO:0000460Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
WBPhenotype:0001933Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
RemarkThe pattern of jsIs821[RAB-3::GFP] localization was disrupted; often reduced or abolished. This phenotype is stronger at higher temperatures. Localization of non-synaptic components appear to be normal. The distribution of a non-synaptic component, mechanosensory channel subunit, appears to be normal. Levels of MEC-18, that is diffusely expressed in the cytoplasm were unchanged in these mutants compared to control animals. The density of TRN microtubules were also unaffected compared to control animals.Paper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00035070
Curator_confirmedWBPerson712
ReferenceWBPaper00035070
Remarku267 contains two missense mutations:F21L and G191E; the flanking sequences for G191E are entered above. The F21L sequence change is c to a (ttc to taa).Person_evidenceWBPerson95
MethodSubstitution_allele