WormBase Tree Display for Variation: WBVar00275299
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WBVar00275299 | Evidence | Paper_evidence | WBPaper00006355 | ||||||
---|---|---|---|---|---|---|---|---|---|
Name | Public_name | y47 | |||||||
Other_name | CE26205:p.Gln1396Ter | ||||||||
Y59A8B.1a.1:c.4186C>T | |||||||||
HGVSg | CHROMOSOME_V:g.17939620G>A | ||||||||
Sequence_details | SMap | S_parent | Sequence | Y59A8B | |||||
Flanking_sequences | attatgccgtggggtgatttttcggaagtt | agggtataaaagaggacacttcggacgatg | |||||||
Mapping_target | Y59A8B | ||||||||
Type_of_mutation | Substitution | c | t | ||||||
SeqStatus | Sequenced | ||||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00035092 | ||||||||
Laboratory | TY | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00001080 | |||||||
Transcript | Y59A8B.1a.1 | VEP_consequence | stop_gained | ||||||
VEP_impact | HIGH | ||||||||
HGVSc | Y59A8B.1a.1:c.4186C>T | ||||||||
HGVSp | CE26205:p.Gln1396Ter | ||||||||
cDNA_position | 4351 | ||||||||
CDS_position | 4186 | ||||||||
Protein_position | 1396 | ||||||||
Exon_number | 9/13 | ||||||||
Codon_change | Cag/Tag | ||||||||
Amino_acid_change | Q/* | ||||||||
Interactor | WBInteraction000052067 | ||||||||
WBInteraction000052434 | |||||||||
Genetics | Interpolated_map_position | V | 13.3321 | ||||||
Mapping_data | In_pos_neg_data | 4305 | |||||||
Description | Phenotype | WBPhenotype:0000006 | Paper_evidence | WBPaper00001077 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Slightly Egl. | Paper_evidence | WBPaper00001077 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000066 | Paper_evidence | WBPaper00001077 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | 85% XX viable. | Paper_evidence | WBPaper00001077 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000583 | Paper_evidence | WBPaper00001077 | |||||||
WBPaper00001011 | |||||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | XX animals are dumpy. | Paper_evidence | WBPaper00001011 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000718 | Paper_evidence | WBPaper00001011 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | As determined by the penetrance of the lin-14(n179) mutant phenotype, based on the [# mutant seam cell nuclei (undivided seam cell nuclei + nuclei that generated precocious alae)/ total # seam cell nuclei] animals after the L3 molt. | Paper_evidence | WBPaper00001011 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Nomarski optics were used to follow the fates of the midbody seam cell nuclei of L3 animals raised at 24C. | Paper_evidence | WBPaper00001011 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Temperature | 24 | Paper_evidence | WBPaper00001011 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001581 | Paper_evidence | WBPaper00001011 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals have 21%(n=20) mutant seam cell nuclei, similar to XXX lin-14 animals (26% n=25) and less mutant than XX lin-14 animals (77% n=40). | Paper_evidence | WBPaper00001011 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006913 | PATO:0000460 | Paper_evidence | WBPaper00001011 | ||||
Curator_confirmed | WBPerson712 | ||||||||
Life_stage | WBls:0000035 | PATO:0000460 | Paper_evidence | WBPaper00001011 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Nomarski optics were used to follow the fates of the midbody seam cell nuclei of L3 animals raised at 24C. | Paper_evidence | WBPaper00001011 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Temperature | 24 | Paper_evidence | WBPaper00001011 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001582 | Paper_evidence | WBPaper00001011 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | XO lin-14(n179) males display significantly more lin-14 seam cell defects than lin-14 animals alone but similar to levels observed for lin-14/Df animals. | Paper_evidence | WBPaper00001011 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Temperature | 20 | Paper_evidence | WBPaper00001011 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Genotype | lin-14(n179) | Paper_evidence | WBPaper00001011 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001583 | Paper_evidence | WBPaper00001011 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | XXX and XXXX progeny are lethal. | Paper_evidence | WBPaper00001011 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_not_observed | WBPhenotype:0000065 | Paper_evidence | WBPaper00001077 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Reference | WBPaper00013841 | ||||||||
WBPaper00001077 | |||||||||
WBPaper00001011 | |||||||||
Method | Substitution_allele |