WormBase Tree Display for Variation: WBVar00275520
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WBVar00275520 | Name | Public_name | zu193 | ||||||
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Sequence_details | SeqStatus | Pending_curation | |||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00007281 | ||||||||
WBStrain00007282 | |||||||||
Laboratory | JJ | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00003397 | |||||||
Interactor (14) | |||||||||
Description | Phenotype (9) | ||||||||
Phenotype_not_observed | WBPhenotype:0000218 | Paper_evidence | WBPaper00031110 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals from strains from either the Sternberg lab or the Eisenmann lab do not exhibit a significant level of overinduction although a very low level (2%) of the animals from the Eisenmann strain exhibit an overinduced phenotype; 0% of the animals from the Sternberg strain exhibit OI. | Paper_evidence | WBPaper00031110 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Probable_null_via_phenotype | Paper_evidence | WBPaper00031110 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000760 | Paper_evidence | WBPaper00002871 | |||||||
WBPaper00003645 | |||||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | The ABar cells of pop-1(zu193) embryos exhibit normal spindle orientation, with the ABar spindle perpendicular to the ABpr spindle. | Paper_evidence | WBPaper00002871 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
In EMS blastomeres isolated from wild type embryos and placed in contact with isolated mom-5(zu193) mutant P2 blastomeres, EMS spindles exhibited wild type orientation suggesting that mom-5 is dispensable in P2 for proper EMS spindle orientation (Figure 4A). | Paper_evidence | WBPaper00003645 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006411 | PATO:0000460 | Paper_evidence | WBPaper00002871 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0006876 | PATO:0000460 | Paper_evidence | WBPaper00003645 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBbt:0006873 | PATO:0000460 | Paper_evidence | WBPaper00003645 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Life_stage | WBls:0000003 | PATO:0000460 | Paper_evidence | WBPaper00003645 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
Phenotype_assay | Treatment | For genetically mosaic partial embryos, wild-type and mutant early EMS and P2 blastomeres were concurrently isolated. EMS and P2 were recombined early in the EMS cell cycle allowing the cells to be in contact for at least 9 min before EMS cytokinesis. | Paper_evidence | WBPaper00003645 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000883 | Paper_evidence | WBPaper00035405 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Nerve ring development is normal | Paper_evidence | WBPaper00035405 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0001133 | Paper_evidence | WBPaper00005375 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | mom-5(zu193) animals exhibited no embryos with aberrant L-R division of EMS (Table 1) | Paper_evidence | WBPaper00005375 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006876 | PATO:0000460 | Paper_evidence | WBPaper00005375 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0001224 | Paper_evidence | WBPaper00060654 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | There are six Wnt receptors encoded in the C. elegans genome: four Frizzled receptors (LIN-17, CFZ-2, MIG-1 and MOM-5,), one Ror receptor (CAM-1) and one Ryk receptor (LIN-18) (Sawa and Korswagen, 2013). We analyzed the effect of loss-of-function mutations for each receptor and found that loss of cam-1, but not the other receptors, caused defective SMDD axonal development (Figure 1D). | Paper_evidence | WBPaper00060654 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0004972 | PATO:0000460 | Paper_evidence | WBPaper00060654 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBbt:0004971 | PATO:0000460 | Paper_evidence | WBPaper00060654 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Reference | WBPaper00038341 | ||||||||
WBPaper00005375 | |||||||||
WBPaper00002871 | |||||||||
WBPaper00026736 | |||||||||
WBPaper00003645 | |||||||||
WBPaper00031110 | |||||||||
WBPaper00035405 | |||||||||
WBPaper00060654 | |||||||||
Method | Allele |