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WormBase Tree Display for Variation: WBVar00296669

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Name Class

WBVar00296669EvidencePaper_evidenceWBPaper00037652
NamePublic_namen4132
Other_nameF33H1.1e.1:c.81-998_81-533del
F33H1.1d.1:c.150-998_150-533del
F33H1.1b.1:c.582-998_582-533del
F33H1.1a.1:c.507-998_507-533del
HGVSgCHROMOSOME_II:g.10161576_10162041del
Sequence_detailsSMapS_parentSequenceF33H1
Flanking_sequencesgtaacagcagccatcacaagccacaagctagccaccgccgagccagtgagctcacagttg
Mapping_targetF33H1
Type_of_mutationDeletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryMT
StatusLive
AffectsGeneWBGene00000914
TranscriptF33H1.1c.1VEP_consequence5_prime_UTR_variant
VEP_impactMODIFIER
cDNA_position?-98
Exon_number1/9
F33H1.1a.1VEP_consequenceintron_variant
VEP_impactMODIFIER
HGVScF33H1.1a.1:c.507-998_507-533del
Intron_number5/12
F33H1.1b.1VEP_consequenceintron_variant
VEP_impactMODIFIER
HGVScF33H1.1b.1:c.582-998_582-533del
Intron_number6/13
F33H1.1e.1VEP_consequenceintron_variant
VEP_impactMODIFIER
HGVScF33H1.1e.1:c.81-998_81-533del
Intron_number1/7
F33H1.1d.1VEP_consequenceintron_variant
VEP_impactMODIFIER
HGVScF33H1.1d.1:c.150-998_150-533del
Intron_number3/10
InteractorWBInteraction000052369
WBInteraction000052370
WBInteraction000504824
WBInteraction000504825
WBInteraction000504826
WBInteraction000541776
GeneticsInterpolated_map_positionII2.1418
DescriptionPhenotypeWBPhenotype:0000306Paper_evidenceWBPaper00037652
Curator_confirmedWBPerson712
RemarkAnimals exhibit a loss of Ppkd-2::GFP expression in male-specific CEM head neurons. | n4132 mutant males do not express lov-1, pkd-2, or klp-6 GFP reporters in the male-specific CEMs,HOB, and RnB neurons. | n4132 also disrupts KLP-6::GFP expression in the core IL2 neurons of males and hermaphrodites from embryogenesis through adulthood. | n4132 abolishes CWP-1::GFP expression in IL2 and PKD neurons. | n4132 specifically disrupts Pnlp-8::GFP in HOB without affecting expression in core neurons. | In n4132 animals, osm-9 expression is disrupted only in the IL2 and PKD neurons. | n4132 does not affect ciliogenic gene expression of intraflagellar transport (IFT) componentOSM-6:;GFP in PKD, core IL2, or other ciliated sensory neurons. | n4132 does not affect ciliogenic gene expression of other IFT reporters including osm-5, bbs-1, bbs-2, bbs-5, and daf-10 in PKD, core IL2, and other ciliated sensory neurons. | The odorant receptor odr-10 and guanylate cyclase (gcy-5 and gcy-32) genes that are expressed in the core nervous system are not affected by the n4132 mutation.Paper_evidenceWBPaper00037652
Curator_confirmedWBPerson712
WBPhenotype:0000649Paper_evidenceWBPaper00037652
Curator_confirmedWBPerson712
Remarkn4132 males exhibit response and Lov defects.Paper_evidenceWBPaper00037652
Curator_confirmedWBPerson712
WBPhenotype:0000843Paper_evidenceWBPaper00037652
Curator_confirmedWBPerson712
WBPhenotype:0004004Paper_evidenceWBPaper00037652
Curator_confirmedWBPerson712
Remarkn4132 males exhibit response and Lov defects.Paper_evidenceWBPaper00037652
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000012Paper_evidenceWBPaper00037652
Curator_confirmedWBPerson712
WBPhenotype:0002535Paper_evidenceWBPaper00037652
Curator_confirmedWBPerson712
RemarkIn n4132 animals, IL2, amphid, and phasmid cilia are intact, as judged by fluorescent dye uptake (200/200 animals normal in dye filling assays) and visualization of an OSM-6::GFP reporter in amphid, phasmid, and male-specific sensory cilia.Paper_evidenceWBPaper00037652
Curator_confirmedWBPerson712
ReferenceWBPaper00037652
MethodDeletion_allele