WormBase Tree Display for WBProcess: WBbiopr:00000076
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| WBbiopr:00000076 | Public_name | ER-associated degradation | |||
|---|---|---|---|---|---|
| Summary | Correctly folding proteins is a severely complicated process. Within eukaryotes an optimal environment for protein folding is provided by the endoplasmic reticulum (ER). In addition, proper folding requires the activity of numerous molecular chaperones and folding enzymes. Despite the controlled environment and numerous molecular helpers, misfolded proteins do sometimes occur. ER-associated degradation (ERAD) is a normal cell function that detects and deals with these occurrences. Through the ERAD process, misfolded proteins are recognized, retrotranslocated to the cytosol, ubiquinated, and then degraded by the proteosome. | ||||
| Other_name | ERAD | ||||
| Related_topic | Specialisation_of | WBbiopr:00000080 | |||
| Involved_entity | Gene (20) | ||||
| Interaction (209) | |||||
| Molecule | WBMol:00002963 | Paper_evidence | WBPaper00030999 | ||
| WBMol:00003099 | Paper_evidence | WBPaper00041269 | |||
| WBMol:00004565 | Paper_evidence | WBPaper00035294 | |||
| WBMol:00004908 | Paper_evidence | WBPaper00030999 | |||
| WBMol:00005300 | Paper_evidence | WBPaper00041269 | |||
| Associated_with | GO_term | GO:0071712 | |||
| Reference (15) |
