WormBase Tree Display for Gene: WBGene00003822

WBGene00003822 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 4
    Name: CGC_name: nsy-1 Person_evidence: WBPerson42
      Sequence_name: F59A6.1
      Molecular_name: F59A6.1a
        F59A6.1a.1
        CE44901
        F59A6.1b
        CE50862
        F59A6.1b.1
      Other_name: esp-8
        ask-1
        xts-1 Person_evidence: WBPerson9709
        srf-6
        CELE_F59A6.1 Accession_evidence: NDB BX284602
      Public_name: nsy-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 25 Oct 2016 10:44:04 WBPerson2970 Name_change: Other_name: xts-1
        3 02 Mar 2018 10:40:21 WBPerson4025 Event: Split_into: WBGene00303064
        4 02 Aug 2019 15:22:42 WBPerson1983 Name_change: Other_name: srf-6
      Split_into: WBGene00303064
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nsy
    Allele: WBVar00296493
      WBVar00296502
      WBVar00296504
      WBVar00296503
      WBVar01499702
      WBVar02148466
      WBVar02148467
      WBVar02148468
      WBVar01477446
      WBVar01982441
      WBVar01498435
      WBVar01239750
      WBVar00088446
      WBVar00088448
      WBVar00088453
      WBVar00234529
      WBVar02109777
      WBVar00000105
      WBVar01248762
      WBVar01993943
      WBVar01491830
      WBVar00253627
      WBVar01934619
      WBVar01934620
      WBVar02129881
      WBVar02129882
      WBVar01393602
      WBVar01393603
      WBVar00223681
      WBVar02017900
      WBVar01473674
      WBVar00729545
      WBVar00223685
      WBVar02029212
      WBVar00729546
      WBVar00223686
      WBVar00729547
      WBVar00729548
      WBVar00729549
      WBVar00223688
      WBVar00729550
      WBVar00729551
      WBVar00729552
      WBVar00091879
      WBVar00729553
      WBVar00729554
      WBVar00729555
      WBVar00223702
      WBVar00729556
      WBVar00729557
      WBVar00729558
      WBVar00729559
      WBVar00729560
      WBVar01792129
      WBVar00729561
      WBVar00729562
      WBVar01559487
      WBVar00729563
      WBVar00729564
      WBVar00729565
      WBVar00729566
      WBVar00314492
      WBVar00729567
      WBVar00223723
      WBVar00171842
      WBVar00729568
      WBVar02087396
      WBVar00171843
      WBVar00729569
      WBVar00729570
      WBVar00729571
      WBVar00729572
      WBVar00729573
      WBVar00729574
      WBVar00241224
      WBVar00602272
      WBVar00729575
      WBVar01642004
      WBVar00729576
      WBVar00729577
      WBVar02012089
      WBVar01372366
      WBVar00729578
      WBVar00729579
      WBVar00729580
      WBVar00729581
      WBVar00729582
      WBVar00729583
      WBVar00268686
      WBVar00365307
      WBVar00365308
      WBVar00365309
      WBVar00365310
      WBVar00365311
      WBVar00365312
      WBVar00365313
      WBVar00365314
      WBVar00365315
      WBVar00296494
      WBVar00365316
      WBVar00296495
      WBVar00365317
      WBVar00296496
      WBVar00296497
      WBVar00365318
      WBVar00296498
      WBVar00365319
      WBVar00296499
      WBVar00365320
      WBVar01626501
      WBVar00365321
      WBVar00296500
      WBVar00296501
      WBVar00296505
      WBVar01949056
      WBVar02145381
      WBVar02145386
      WBVar00249856
      WBVar00103861
      WBVar00103863
      WBVar00249876
    Legacy_information: ky400 homozygotes lose neuronal asymmetry, express str-2::GFPin both AWC neurons. ky542, ky397 similar.All 3 probable nulls: stop codons in F59A6.1, encoding homolog of Human MAPKKK ASK1.
    Strain (11)
    RNASeq_FPKM (74)
    GO_annotation (59)
    Ortholog (51)
    Paralog: WBGene00004161 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: nsy-1 encodes a MAP kinase kinase kinase (MAP3K) that is orthologous to the mammalian apoptosis signal-regulating kinase (ASK) family of protein kinases; nsy-1 activity is required for chemotaxis, egg laying, pathogen response, and response to anoxia; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; NSY-1 interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons. Paper_evidence: WBPaper00003760
            WBPaper00004610
            WBPaper00004669
            WBPaper00005370
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 11 Jan 2011 00:00:00
      Automated_description: Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and positive regulation of macromolecule biosynthetic process. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Expressed in head; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease and perinatal necrotizing enterocolitis. Is an ortholog of human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:670 Homo sapiens Paper_evidence: WBPaper00038418
          Curator_confirmed: WBPerson324
          Date_last_updated: 31 May 2019 00:00:00
    Potential_model: DOID:12858 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6857)
      DOID:8677 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6857)
  Models_disease_asserted: WBDOannot00000693
  Molecular_info: Corresponding_CDS: F59A6.1a
      F59A6.1b
    Corresponding_CDS_history: F59A6.1c:wp264
    Corresponding_transcript: F59A6.1a.1
      F59A6.1b.1
    Other_sequence (29)
    Associated_feature: WBsf657564
      WBsf987777
      WBsf987778
      WBsf987779
      WBsf987780
      WBsf1012168
      WBsf1012169
      WBsf221219
  Experimental_info: RNAi_result (25)
    Expr_pattern (11)
    Drives_construct: WBCnstr00002286
      WBCnstr00013632
      WBCnstr00019901
      WBCnstr00019902
      WBCnstr00035850
    Construct_product: WBCnstr00008944
      WBCnstr00008945
      WBCnstr00008946
      WBCnstr00014195
      WBCnstr00014559
      WBCnstr00019902
      WBCnstr00035850
      WBCnstr00039541
    Antibody: WBAntibody00002507
    Microarray_results (20)
    Expression_cluster (111)
    SAGE_tag (35)
    Interaction (112)
    Anatomy_function: WBbtf0508
      WBbtf0510
      WBbtf1062
    WBProcess: WBbiopr:00000008
      WBbiopr:00000014
      WBbiopr:00000039
  Map_info: Map: II Position: -2.59263 Error: 0.001611
    Positive: Inside_rearr: ccDf2
        maDf4
      Positive_clone: F59A6 Author_evidence: Sagasti A
          Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: ccDf11
    Mapping_data: Pos_neg_data: 10652
        10653
        10654
        10655
  Reference (158)
  Picture: WBPicture0000013079
    WBPicture0000013081
    WBPicture0000013093
  Remark: Sequence connection (nsy-1 = F59A6.1) from Sagasti A and Bargmann C [030204 ck1]
  Method: Gene