| WBGene00006808 | SMap | S_parent | Sequence | C01G10 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-76 | Person_evidence | WBPerson261 |
| | | Sequence_name | C01G10.11 |
| | | Molecular_name (18) |
| | | Other_name | CELE_C01G10.11 | Accession_evidence | NDB | BX284605 |
| | | Public_name | unc-76 |
| | DB_info | Database | AceView | gene | 5P559 |
| | | | WormQTL | gene | WBGene00006808 |
| | | | WormFlux | gene | WBGene00006808 |
| | | | NDB | locus_tag | CELE_C01G10.11 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006808|UniProtKB=E0AHC6 |
| | | | | family | PTHR12394 |
| | | | NCBI | gene | 180014 |
| | | | RefSeq | protein | NM_001269717.3 |
| | | | | | NM_001269716.3 |
| | | | | | NM_001269719.3 |
| | | | | | NM_001269718.3 |
| | | | | | NM_074311.7 |
| | | | | | NM_171553.6 |
| | | | TREEFAM | TREEFAM_ID | TF313128 |
| | | | TrEMBL | UniProtAcc | E0AHC6 |
| | | | | | E0AHC4 |
| | | | | | E0AHC3 |
| | | | | | E0AHC5 |
| | | | | | Q7JL61 |
| | | | | | Q7JL62 |
| | | | UniProt_GCRP | UniProtAcc | E0AHC6 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143591 |
| | Allele | WBVar00241549 | Inferred_automatically | From strain object: NJ388 |
| | | WBVar00088429 |
| | | WBVar02146341 |
| | | WBVar02146342 |
| | | WBVar01463220 |
| | | WBVar01463221 |
| | | WBVar01463222 |
| | | WBVar01463223 |
| | | WBVar01499705 |
| | | WBVar01463224 |
| | | WBVar01463225 |
| | | WBVar01463226 |
| | | WBVar01463227 |
| | | WBVar01463228 |
| | | WBVar00143591 |
| | | WBVar00018205 |
| | | WBVar01800191 |
| | | WBVar01744712 |
| | | WBVar01800192 |
| | | WBVar01744713 |
| | | WBVar01800193 |
| | | WBVar00018210 |
| | | WBVar01828413 |
| | | WBVar01800194 |
| | | WBVar01800195 |
| | | WBVar01800196 |
| | | WBVar00018215 |
| | | WBVar01800197 |
| | | WBVar01800198 |
| | | WBVar01975608 |
| | | WBVar00018220 |
| | | WBVar01800199 |
| | | WBVar01975609 |
| | | WBVar01975610 |
| | | WBVar01800200 |
| | | WBVar01975611 |
| | | WBVar01800201 |
| | | WBVar00018225 |
| | | WBVar01975612 |
| | | WBVar01800202 |
| | | WBVar01975613 |
| | | WBVar00018230 |
| | | WBVar00018235 |
| | | WBVar02109411 |
| | | WBVar00018240 |
| | | WBVar02109412 |
| | | WBVar00018245 |
| | | WBVar02107392 |
| | | WBVar00018250 |
| | | WBVar00018255 |
| | | WBVar00018260 |
| | | WBVar02024715 |
| | | WBVar00018265 |
| | | WBVar00600891 |
| | | WBVar01775667 |
| | | WBVar01775668 |
| | | WBVar01809074 |
| | | WBVar01809075 |
| | | WBVar01775669 |
| | | WBVar01775670 |
| | | WBVar01809076 |
| | | WBVar01703200 |
| | | WBVar01775671 |
| | | WBVar01775672 |
| | | WBVar01071513 |
| | | WBVar01071514 |
| | | WBVar01071515 |
| | | WBVar01071516 |
| | | WBVar01071517 |
| | | WBVar01071518 |
| | | WBVar01485059 |
| | | WBVar01071519 |
| | | WBVar01071520 |
| | | WBVar01071521 |
| | | WBVar01071522 |
| | | WBVar01071523 |
| | | WBVar00145227 |
| | | WBVar01071524 |
| | | WBVar01071525 |
| | | WBVar01071526 |
| | | WBVar01071527 |
| | | WBVar00090458 |
| | | WBVar01071528 |
| | | WBVar00090459 |
| | | WBVar01071529 |
| | | WBVar01071530 |
| | | WBVar01071531 |
| | | WBVar01071532 |
| | | WBVar01071533 |
| | | WBVar01071534 |
| | | WBVar01071535 |
| | | WBVar01071536 |
| | | WBVar01071537 |
| | | WBVar01071538 |
| | | WBVar01071539 |
| | | WBVar01071540 |
| | | WBVar01071541 |
| | | WBVar01071542 |
| | | WBVar01071543 |
| | | WBVar01071544 |
| | | WBVar02078171 |
| | | WBVar01071545 |
| | | WBVar01071546 |
| | | WBVar01071547 |
| | | WBVar01071548 |
| | | WBVar01071549 |
| | | WBVar01071550 |
| | | WBVar01071551 |
| | | WBVar01071552 |
| | | WBVar00090488 |
| | | WBVar01071553 |
| | | WBVar01489509 |
| | | WBVar01071554 |
| | | WBVar01071555 |
| | | WBVar01071556 |
| | | WBVar01071557 |
| | | WBVar01071558 |
| | | WBVar01071559 |
| | | WBVar01071560 |
| | | WBVar01071561 |
| | | WBVar01071562 |
| | | WBVar01071563 |
| | | WBVar02038828 |
| | | WBVar02038829 |
| | | WBVar02048306 |
| | | WBVar01590520 |
| | | WBVar01590521 |
| | | WBVar00478291 |
| | | WBVar00478292 |
| | | WBVar01474431 |
| | | WBVar00478293 |
| | | WBVar02032064 |
| | | WBVar02032065 |
| | | WBVar00478294 |
| | | WBVar02032066 |
| | | WBVar00478295 |
| | | WBVar00478296 |
| | | WBVar02032067 |
| | | WBVar00478297 |
| | | WBVar02032068 |
| | | WBVar02032069 |
| | | WBVar00478298 |
| | | WBVar00478299 |
| | | WBVar01500212 |
| | | WBVar00478300 |
| | | WBVar01500213 |
| | | WBVar00478301 |
| | | WBVar00478302 |
| | | WBVar00478303 |
| | | WBVar00478304 |
| | | WBVar00478305 |
| | | WBVar00478306 |
| | | WBVar01499299 |
| | | WBVar00478307 |
| | | WBVar00478308 |
| | | WBVar00478309 |
| | | WBVar00478310 |
| | | WBVar00478311 |
| | | WBVar00478312 |
| | | WBVar01499316 |
| | | WBVar01402376 |
| | | WBVar02034601 |
| | | WBVar01499698 |
| | Legacy_information | e911pdi : inactive tends to curl dumpyish; Egl-c; amphid phasmid PDE axons abnormal; dorsal extensions of DD and VD neurons frequently grow in abnormal directions often fail to connect to dorsal nerve cord. ES3 ME0. NA1. |
| | | [C.elegansII] e911pdi : inactive, tends to curl, dumpyish; Egl-c; amphid, phasmid, PDE, PVP, other axons abnormal; dorsal extensions of DD and VD neurons frequently grow in abnormal directions, often fail to connect to dorsal nervecord. Defects in axonal elongation and fasciculation along nerve cords. ES3 ME0. NA1. Cloned: 1.8 kb transcripts, encode predicted 385 or 376 aa novel proteins. Epitope-tagged UNC-76 detected in axons. [Hedgecock et al. 1985; McIntire et al. 1992; MT] |
| | Strain (54) |
| | RNASeq_FPKM (74) |
| | GO_annotation (22) |
| | Ortholog (39) |
| | Structured_description | Concise_description | unc-76 encodes a predicted coiled-coil protein that belongs to the FEZ (fasciculation and elongation protein; zygin/zeta-1) family of proteins; UNC-76 activity is required for normal axonal outgrowth and fasciculation and hence, normal locomotion; UNC-76 expression begins during embryogenesis and is present in all axons throughout development; UNC-76 localizes to both axons and cell bodies. | Paper_evidence | WBPaper00002751 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 31 May 2006 00:00:00 |
| | | Automated_description | Enables syntaxin binding activity. Involved in anterograde axonal protein transport; axonal fasciculation; and regulation of cellular component organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Expressed in neurons and somatic nervous system. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human FEZ1 (fasciculation and elongation protein zeta 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed (2) |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3659) |
| Molecular_info | Corresponding_CDS | C01G10.11a |
| | | C01G10.11b |
| | | C01G10.11c |
| | | C01G10.11d |
| | | C01G10.11e |
| | | C01G10.11f |
| | Corresponding_CDS_history | C01G10.11a:wp151 |
| | | C01G10.11b:wp151 |
| | Corresponding_transcript | C01G10.11a.1 |
| | | C01G10.11b.1 |
| | | C01G10.11c.1 |
| | | C01G10.11d.1 |
| | | C01G10.11e.1 |
| | | C01G10.11f.1 |
| | Other_sequence (20) |
| | Associated_feature (21) |
| Experimental_info | RNAi_result | WBRNAi00089749 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027631 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00009926 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089948 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00039322 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00086127 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090266 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090108 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1621 |
| | | Expr1019687 |
| | | Expr1032875 |
| | | Expr1143433 |
| | | Expr2017905 |
| | | Expr2036041 |
| | Drives_construct | WBCnstr00001401 |
| | | WBCnstr00034141 |
| | Construct_product (15) |
| | Antibody | WBAntibody00000143 |
| | Microarray_results (40) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_CoreEnriched |
| | | WBPaper00037950:A-class-motor-neurons_embryo_enriched |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00040209:B.thuringiensis_upregulated_N2 |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057254:MWCNT_upregulated_mRNA |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061210:huIs179_upregulated |
| | | WBPaper00061274:hypergravity_10xg_upregulated |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:AVK |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:CAN |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:DVC |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIC |
| | | WBPaper00061340:RID |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMB |
| | | WBPaper00061466:nath-10(icb102)_downregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:dld-1-skn-1_16701 |
| | | WBPaper00061527:zfp-1_3975-smk-1_2897 |
| | | WBPaper00061651:AVJ_enriched |
| | | WBPaper00061651:AVL_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:PDA_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061651:PVC_enriched |
| | | WBPaper00061651:PVM_enriched |
| | | WBPaper00061651:PVR_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061651:VB02_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061651:VC_enriched |
| | | WBPaper00061651:VD_DD_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_starved |
| | | WBPaper00064055:trl-1(cas1078)_downregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1078)_downregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064505:tamoxifen_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065841:10_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025032:cluster_4 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040963:TA200_down |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_0.2mM_Down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048563:L1_DD_enriched |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (37) |
| Map_info | Map | V | Position | 7.32052 | Error | 0.012665 |
| | Well_ordered |
| | Positive | Positive_clone | C01G10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | C08C1 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | nDf31 |
| | | | ozDf1 |
| | Mapping_data | 2_point (15) |
| | | Multi_point (103) |
| | | Pos_neg_data | 4288 |
| | | | 4289 |
| | | | 4290 |
| | | | 4304 |
| | | | 8977 |
| | Landmark_gene |
| Reference (130) |
| Method | Gene |
