WormBase Tree Display for Gene: WBGene00006814

WBGene00006814 SMap: S_parent: Sequence: B0496
  Identity: Version: 3
    Name: CGC_name: unc-82 Person_evidence: WBPerson261
      Sequence_name: B0496.3
      Molecular_name (29)
      Other_name: CELE_B0496.3 Accession_evidence: NDB BX284604
      Public_name: unc-82
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change (3)
      Acquires_merge: WBGene00015212
        WBGene00015213
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143842
    Allele (253)
    Possibly_affected_by: WBVar02153065
    Legacy_information: e1220 : slow good movement abnormal reduced muscle birefringence abnormal body muscle ultrastruture with enlarged thick filaments etc. ES2 ME2. NA9 (e1323 r194 etc. : all resemble e1220).
      See also e1220, e1323
      [C.elegansII] e1220 : slow, good movement, abnormal reduced muscle birefringence; abnormal body muscle ultrastructure with enlarged thick filaments; weaker pharyngeal muscle abnormalities. ES2 ME2. OA>5: e1323, r194, st1323 etc. (all resemble e1220). [Waterston and Brenner 1980; RW]
    Strain: WBStrain00033499
      WBStrain00033522
      WBStrain00033523
      WBStrain00037392
      WBStrain00004275
      WBStrain00004300
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (45)
    Paralog (19)
    Structured_description: Concise_description: unc-82 encodes a serine/threonine kinase related to the human ARK5/SNARK (NUAK1/NUAK2) and the PAR-1 and SNF1/AMP-Activated kinase (AMPK) protein kinase families; during development, UNC-82 activity is required for proper organization of internal (membrane-distal) proteins of myosin thick filaments and M-lines in conjunction with embryonic elongation; an UNC-82::GFP reporter fusion is expressed in muscle cells and is associated with M lines; UNC-82::GFP expression is also seen in the pharynx. Paper_evidence: WBPaper00035423
          Curator_confirmed: WBPerson1843
          Date_last_updated: 04 Jan 2011 00:00:00
      Automated_description: A structural constituent of muscle. Involved in striated muscle myosin thick filament assembly and striated muscle paramyosin thick filament assembly. Located in M band. Expressed in body wall musculature. Human ortholog(s) of this gene implicated in anencephaly. Is an ortholog of human NUAK1 (NUAK family kinase 1) and NUAK2 (NUAK family kinase 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060668 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:29558)
      DOID:13223 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14311)
  Molecular_info: Corresponding_CDS: B0496.3a
      B0496.3b
      B0496.3c
      B0496.3d
      B0496.3e
      B0496.3f
      B0496.3g
      B0496.3h
      B0496.3i
    Corresponding_CDS_history: B0496.3a:wp187
      B0496.3a:wp209
      B0496.3b:wp187
      B0496.3b:wp209
      B0496.3c:wp209
    Corresponding_transcript (11)
    Other_sequence (35)
    Associated_feature: WBsf660290
      WBsf660291
      WBsf660292
      WBsf660293
      WBsf660294
      WBsf660295
      WBsf660296
      WBsf660297
      WBsf718121
      WBsf996973
      WBsf996974
      WBsf996975
      WBsf996976
      WBsf996977
      WBsf996978
      WBsf996979
      WBsf996980
      WBsf996981
      WBsf996982
      WBsf996983
      WBsf996984
      WBsf1017708
      WBsf1017709
      WBsf1017710
      WBsf1017711
      WBsf1017712
      WBsf1017713
      WBsf228531
      WBsf228532
      WBsf228533
    Gene_product_binds: WBsf919647
  Experimental_info: RNAi_result (25)
    Expr_pattern: Expr8836
      Expr1015480
      Expr1032879
      Expr1143277
      Expr2017911
      Expr2036047
    Drives_construct: WBCnstr00007842
      WBCnstr00013549
      WBCnstr00034140
    Construct_product: WBCnstr00007842
      WBCnstr00013549
      WBCnstr00034140
      WBCnstr00041813
      WBCnstr00041814
    Microarray_results (53)
    Expression_cluster (211)
    Interaction (55)
  Map_info: Map: IV Position: 3.33492 Error: 0.000317
    Positive: Positive_clone: B0496 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 108
      Multi_point: 286
        912
        913
        914
        915
      Pos_neg_data: 3262
        8144
        8145
  Reference (40)
  Method: Gene